ID G1KY76_ANOCA Unreviewed; 1100 AA.
AC G1KY76;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif 6 {ECO:0000313|Ensembl:ENSACAP00000020687.3};
GN Name=ADAMTS6 {ECO:0000313|Ensembl:ENSACAP00000020687.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000020687.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000020687.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000020687.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000020687.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR AlphaFoldDB; G1KY76; -.
DR STRING; 28377.ENSACAP00000020687; -.
DR Ensembl; ENSACAT00000025788.3; ENSACAP00000020687.3; ENSACAG00000027734.3.
DR eggNOG; KOG3538; Eukaryota.
DR GeneTree; ENSGT00940000156571; -.
DR HOGENOM; CLU_000660_5_1_1; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000027734; Expressed in forelimb bud and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04273; ZnMc_ADAMTS_like; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723:SF27; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 6; 1.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00276}; Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1100
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033068992"
FT DOMAIN 231..449
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 1062..1100
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT ACT_SITE 385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 384
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 388
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 394
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 1100 AA; 123995 MW; AA83EF98CE44CC9F CRC64;
ERYHINILKW ALLLCYCPEF LSYLEHYQLT VPIRVDHNGA FLSFTVKNTK STRRKKRSTY
DQELAVSNLF FKLSAYGKHF HLNLTLNTDL VSKHFTVEYW GKDGPQWKHD FLDNCHYTGY
LHGEHGTTKV ALSNCNGLHG VIATEDEEYF IEPLRNLTEN SSNFSYESGH PHVIYKKSAI
YHHLTAWSAV TFPWKHKPWW LNNTDAFPTL HPVNHTLSSN HRLKRSISTE RFVETLVVAD
KMMVGYHGRK DIEHYILSVM NIVAKLYRDS SLGNVVNIIV TRLIVLTEDQ PNLEINHHAD
KSLDSFCKWQ KSILSHQSDG NTISENGIAH HDNAVLITRY DICTYKNKPC GTLGLASVAG
MCEPERSCSI NEDIGLGSAF TIAHEIGHNF GMNHDGIGNS CGTKGHEAAK LMAAHITANT
NPFSWSACSR DYITSFLDSG RGTCLDNEPP KRDFLYPAVA PGQVYDADEQ CRFQYGATSR
QCKYGEVCRE LWCLSKSNRC VTNSIPAAEG TLCQTGSIEK GWCYQGDCVP FGTWPQSIDG
GWGPWNCEKC MVFSLLLLLF FQMYKICNMF SRPSGGGKYC LGERKRYRSC NTDPCPFGAR
DFREKQCADF DNMPFRGKYY NWKPYTGGGV KPCALNCLAE GYNFYTERAP AVIDGTQCNA
DSLDICINGE CKHVGCDNIL GSEAKEDRCR VCGGDGSTCE VIEGFFNDTL PRGGYMEVVQ
IPKGSVHIEI KEVTVSKNYI ALKSEEDDYY INGAWTIDWP RKFDVAGTAF HYKRPADEAE
SLEALGPTSE NLIVMILLQE QNLGIRYKFN VPISRTGSGD NEVGFTWNHL PWSECSATCA
GGSQKQEIVC KRLDDNSIVQ NNYCDLDNKP PENQRTCNTE PCPTEWFIGD WSECSKTCDG
GMRSRTVLCI RKIGPSEEET LDSIHCLTHR PIEKESCNNQ SCPPQWIPLD WSECTPKCGP
GFKHRIVLCK SSDLSKTFPV AHCQEENKPP VRMRCSLGRC PPPRWIMGDW GQCSAQCGLG
QQMRTVQCLS YTGQASSDCP DTLRPPSMQQ CESKCDSTPI SNTEECKDVN KVAYCPLVLK
FKFCSRAYFR QMCCKTCQGH
//
