ID G1L0J6_AILME Unreviewed; 378 AA.
AC G1L0J6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Chitobiase {ECO:0000313|Ensembl:ENSAMEP00000000398.2};
GN Name=CTBS {ECO:0000313|Ensembl:ENSAMEP00000000398.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000000398.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000000398.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000000398.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family.
CC {ECO:0000256|ARBA:ARBA00009336, ECO:0000256|RuleBase:RU004453}.
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DR RefSeq; XP_002930839.1; XM_002930793.1.
DR AlphaFoldDB; G1L0J6; -.
DR STRING; 9646.ENSAMEP00000000398; -.
DR Ensembl; ENSAMET00000000413.2; ENSAMEP00000000398.2; ENSAMEG00000000372.2.
DR GeneID; 100483400; -.
DR KEGG; aml:100483400; -.
DR CTD; 1486; -.
DR eggNOG; KOG2806; Eukaryota.
DR GeneTree; ENSGT00390000012891; -.
DR HOGENOM; CLU_061189_1_0_1; -.
DR InParanoid; G1L0J6; -.
DR TreeFam; TF332677; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd02875; GH18_chitobiase; 1.
DR Gene3D; 3.10.50.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR029070; Chitinase_insertion_sf.
DR InterPro; IPR047898; DIAC_cat.
DR InterPro; IPR001223; Glyco_hydro18_cat.
DR InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR46290; DI-N-ACETYLCHITOBIASE; 1.
DR PANTHER; PTHR46290:SF1; DI-N-ACETYLCHITOBIASE; 1.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR SMART; SM00636; Glyco_18; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS01095; GH18_1; 1.
DR PROSITE; PS51910; GH18_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..378
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030170441"
FT DOMAIN 1..378
FT /note="GH18"
FT /evidence="ECO:0000259|PROSITE:PS51910"
SQ SEQUENCE 378 AA; 42786 MW; 3DCD1531C4BB630E CRC64;
MTPPQRGRLC LLARPPHGVP ALAVLLLSLL PFWAGARCPC QDPALCQPIT QHPDFEVFVF
DVGSKTWKFY DWSHITTVVI FGEYDPELMC YAHSHGARVV LKGDAPLKNI TDPIFRASWI
AQKVKLAKTQ YMDGINIDIE QGANCLSPEY YALTTLVKET TDSFHREIKG SQVTFDVTWS
PKSKDRCYNY AGIADACDFL FVMSYDERSQ ALSECIAAAN APYKETLTGY DDYIKIGINP
KKLVMGVPWY GYDYTCLNLL EDRVCTIPKV PSWRASCGIT SGRQVPYKIM MKQVNSSISG
SHWDKDQQAP YYNYKDSSGH FHQVWYDNPQ SISLKAAYIQ KHGLRGIGMW HANCLDYSGD
AVAKQQTEEM WKVLKPKL
//
