ID G1L0N0_AILME Unreviewed; 482 AA.
AC G1L0N0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Aprataxin and PNKP like factor {ECO:0000313|Ensembl:ENSAMEP00000000432.2};
GN Name=APLF {ECO:0000313|Ensembl:ENSAMEP00000000432.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000000432.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000000432.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000000432.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1L0N0; -.
DR STRING; 9646.ENSAMEP00000000432; -.
DR Ensembl; ENSAMET00000000448.2; ENSAMEP00000000432.2; ENSAMEG00000000409.2.
DR eggNOG; ENOG502R7QZ; Eukaryota.
DR GeneTree; ENSGT00390000010591; -.
DR HOGENOM; CLU_043152_0_0_1; -.
DR TreeFam; TF326160; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd22717; FHA_APLF; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR039253; APLF.
DR InterPro; IPR019406; APLF_PBZ.
DR InterPro; IPR041388; FHA_2.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR21315:SF2; APRATAXIN AND PNK-LIKE FACTOR; 1.
DR PANTHER; PTHR21315; UNCHARACTERIZED; 1.
DR Pfam; PF17913; FHA_2; 1.
DR Pfam; PF10283; zf-CCHH; 2.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 16..64
FT /note="PNK FHA"
FT /evidence="ECO:0000259|Pfam:PF17913"
FT DOMAIN 377..402
FT /note="Aprataxin and PNK-like factor PBZ"
FT /evidence="ECO:0000259|Pfam:PF10283"
FT DOMAIN 419..441
FT /note="Aprataxin and PNK-like factor PBZ"
FT /evidence="ECO:0000259|Pfam:PF10283"
FT REGION 127..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 482 AA; 53238 MW; AF9728C45CA6ABD5 CRC64;
MSGGFELQPQ DGGPRVALAP GETVIGRGPL LGITDKRVSR RHAILEVVGG QLRIKPIHTN
PCFYQSSKKS QLLPLKRNLW RWLNPGDSFS LLVDKYIFCV FSTHSETEME CTLRNSQMLD
EDNILNKTPK SFSVNSPDET TGAPQLERST EIAKTQTTSA NSECFLGECR DLSKQQSNPA
QRRRILPAWM LTENLSDQNL SAPVSSGDNN IIQGSGKDGI CEDKTQVNIT QQGRKRLISS
GSSESTSAEQ DTGKKCKNAD QEESIISSKA VPKSCSAIMF SNAEANDMKA RTQRSEIPIE
ELGKVPEHKS IVKGTRSKES EVMSYSESHL GAQDKSFHEE SQGSPPESSS DLSSSETVHA
KATDSVAQSS EENKIKRTSC MYGANCYRKN PVHFQHFSHP GDSDYGGVQV MCQDEADDRP
ECPYGASCYR KNPQHKIEYR HSALPADFWR MAGSCRHSVM SAELCLSAPC VTPKRACLFL
RE
//