ID G1L291_AILME Unreviewed; 724 AA.
AC G1L291;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 5 {ECO:0000313|Ensembl:ENSAMEP00000000996.2};
GN Name=ITIH5 {ECO:0000313|Ensembl:ENSAMEP00000000996.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000000996.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000000996.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000000996.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1L291; -.
DR Ensembl; ENSAMET00000001035.2; ENSAMEP00000000996.2; ENSAMEG00000000893.2.
DR GeneTree; ENSGT00940000158317; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF62; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 78..261
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 332..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 79926 MW; 0B7B36AE591B6713 CRC64;
YDSGPPPSTV ISQNDTFAKV TFKPSVVQQA RIAQNGVLGD LIIRYDVNRE QSIGDIQVLN
GYFVHYFAPK DLPPLPKNVV FVLDSSASMV GTKLRQTKDA LFTILHDLRP QDHFSIIGFS
NRIKVWKDHL VSVTPDNVRD GKVYIHHMSP TGGTDINGAL QRAIKLLNDY VAHNDIEDRS
VSLIIFLTDG KPTVGETHTL KILNNTKEAA RGQICIFTIG IGNDVDFMLL EKLSLENCGL
TRRVLEEDDA GAQLIGFYDE IRTPLLSDIR VDYPPALVEQ ATRTLFPNYF NGSEIVIAGK
LADRKVGQLH VEVTASNSKK FVILKTDVPV EPQRAGRGET GSARPQAGGT EPRNHVERLW
SYLTVRELLS SWRHSRDEQD RERLRQKAQA LALAYRFLTP LTAMHLRSAG QPEKLEEAQG
VSAAVGPETV MQSVRGASPQ PGPALKKPYS PRIKVSKTSV DGDPHFVVDF PLNKLTVCFN
IDGQPGDILR LVSDHADSGV TVNGELIGAP APPGGHKKQR TYFRTITILV NKPERSYLEI
TPSRVILDGG DRLVLPCNQS TVVGSRGLEV SVSANANVTV TIQGTVAFVI LIHLYKRPAP
YQRDHLGFYI SHSEGLSSNC HGLLGQFLNQ DARLTEEPAR LSKDPTHPPL PKAGEQAETV
LKVKGHQVPV VWKQRKIYNG EEQVDCWFAR NNAAKLIDGE YKDYLAAHPF DSETSFGPGL
SRGL
//
