GenomeNet

Database: UniProt
Entry: G1L2M4_AILME
LinkDB: G1L2M4_AILME
Original site: G1L2M4_AILME 
ID   G1L2M4_AILME            Unreviewed;       989 AA.
AC   G1L2M4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-SEP-2017, entry version 50.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 1 {ECO:0000313|Ensembl:ENSAMEP00000001134};
GN   Name=KCNH1 {ECO:0000313|Ensembl:ENSAMEP00000001134};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001134, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000001134}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000001134}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000001134}.
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DR   EMBL; ACTA01003073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01011073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01019073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01027073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01035073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01043072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01051072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01059072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01187062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01195060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000001134; -.
DR   Ensembl; ENSAMET00000001178; ENSAMEP00000001134; ENSAMEG00000001083.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00760000118772; -.
DR   InParanoid; G1L2M4; -.
DR   OMA; KGEDWNK; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   TreeFam; TF313130; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR030170; EAG1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF564; PTHR10217:SF564; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01464; EAGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Ion channel {ECO:0000256|SAAS:SAAS00091826};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00807593};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00807732};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00807568};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00807693}.
FT   TRANSMEM    220    239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    376    400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    449    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    478    502       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       14     94       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       93    145       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      581    681       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      930    957       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   989 AA;  111258 MW;  BC82E189F452BFE4 CRC64;
     MTMAGGRRGL VAPQNTFLEN IVRRSSDTNF VLGNAQIVDW PIVYSNDGFC KLSGYHRAEV
     MQKSSTCSFM YGELTDKDTI EKVRQTFENY EMNSFEILMY KKNRTPVWFF VKIAPIRNEQ
     DKVVLFLCTF SDITAFKQPI EDDSCKGWGK FARLTRALTS SRGVLQQLAP SVQKGENVHK
     HSRLAEVLQL GSDILPQYKQ EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS
     FKTRQNNVAW LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL
     LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF SSLKVVRLLR
     LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI GDYEIFDEDT KTIRNNSWLY
     QLAMDIGSPY QFNGSGSGKW EGGPSKNSVY ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA
     VAIMMIGSLL YATIFGNVTT IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI
     VSTWSMSRGI DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV
     HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK EATLAQSCAN
     VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN LRKRIVFRKI SDVKREEEER
     MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA RLAAERGSRD PDDLDVEKGS ALPEHASANH
     SLAKASVVTV RESPATPVAF QAASSAAVAD HGRLYAPGAE CLGARAGGGD CARRKGWARF
     RDACGKAEDW SQVAKAESME TLPDRTKASG EATLKKTDSC DSGITKSDLR LDSVSEARSP
     QDRSPILAEV KHSFYPIPEQ TLQATVLEVK HELKEDIKAL NTKMTNIEKQ LSEILRILTS
     RRSSQSPQEL FEISRPQSPE SERDIFGAS
//
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