ID G1L2R6_AILME Unreviewed; 415 AA.
AC G1L2R6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN Name=TRAF1 {ECO:0000313|Ensembl:ENSAMEP00000001176.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001176.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000001176.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000001176.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR RefSeq; XP_002916012.1; XM_002915966.3.
DR RefSeq; XP_011218975.1; XM_011220673.2.
DR RefSeq; XP_019651675.1; XM_019796116.1.
DR RefSeq; XP_019651676.1; XM_019796117.1.
DR RefSeq; XP_019651677.1; XM_019796118.1.
DR RefSeq; XP_019651678.1; XM_019796119.1.
DR RefSeq; XP_019651679.1; XM_019796120.1.
DR RefSeq; XP_019651680.1; XM_019796121.1.
DR Ensembl; ENSAMET00000001220.2; ENSAMEP00000001173.2; ENSAMEG00000001116.2.
DR Ensembl; ENSAMET00000001224.2; ENSAMEP00000001176.2; ENSAMEG00000001116.2.
DR GeneTree; ENSGT00940000161076; -.
DR TreeFam; TF321154; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd03779; MATH_TRAF1; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR037306; TRAF1_MATH.
DR InterPro; IPR032070; TRAF_BIRC3-bd.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF96; TNF RECEPTOR-ASSOCIATED FACTOR 1; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR PIRSF; PIRSF015614; TRAF; 2.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR015614};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Zinc {ECO:0000256|PIRNR:PIRNR015614}.
FT DOMAIN 265..411
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT REGION 60..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 186..262
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 415 AA; 45948 MW; 53F98533E6A34DF9 CRC64;
MASGPASSPH PAPDENEFPF GCPPTVCQDP SEPRALCCAA CLSEHVRTGE DRICAKCRGD
DPQSVSPGSL LSQEEDHPEA AEAEVGCPFA GVGCSYKGSV KLLQEHEVAS QTTHLNLLLG
FLKQRKAQEG SGLGSGPMAL EQNLSDLQLQ AAVEVAGDLE VDCYRAPRSE SQDELALQHF
MKEKLLAELE EKLRVFENIV AVLNKEVEAS HLALAASIHQ SQLDREHILS LEQRVVELQE
TLAQKDQALG KLEQSLRLME EASFDGTFLW KITNVTRRCH ESACGRTVSL FSPAFYTAKY
GYKLCLRLYL NGDGTGKRTH LSLFIVIMRG EYDALLPWPF RNKVTFMLLD QNHREHAIDA
FRPDLSSASF QRPQSETNVA SGCPLFFPLN RLQSPKHAYV KDDTMFLKCI VETSA
//
