ID G1L3U6_AILME Unreviewed; 334 AA.
AC G1L3U6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=3beta-hydroxysteroid 3-dehydrogenase {ECO:0000256|ARBA:ARBA00023621};
DE EC=1.1.1.270 {ECO:0000256|ARBA:ARBA00023621};
GN Name=HSD17B7 {ECO:0000313|Ensembl:ENSAMEP00000001556.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001556.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000001556.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000001556.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha-
CC methylzymosterol + NADP(+); Xref=Rhea:RHEA:36379, ChEBI:CHEBI:1949,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:136486; EC=1.1.1.270;
CC Evidence={ECO:0000256|ARBA:ARBA00033683};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36380;
CC Evidence={ECO:0000256|ARBA:ARBA00033683};
CC -!- PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from
CC lanosterol: step 5/6. {ECO:0000256|ARBA:ARBA00023589}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. ERG27 subfamily. {ECO:0000256|ARBA:ARBA00023593}.
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DR RefSeq; XP_002920144.1; XM_002920098.3.
DR AlphaFoldDB; G1L3U6; -.
DR STRING; 9646.ENSAMEP00000001556; -.
DR Ensembl; ENSAMET00000001616.2; ENSAMEP00000001556.2; ENSAMEG00000001450.2.
DR GeneID; 100477716; -.
DR KEGG; aml:100477716; -.
DR CTD; 51478; -.
DR eggNOG; KOG1478; Eukaryota.
DR GeneTree; ENSGT00390000013340; -.
DR HOGENOM; CLU_029944_2_0_1; -.
DR InParanoid; G1L3U6; -.
DR TreeFam; TF105433; -.
DR UniPathway; UPA00770; UER00758.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0000253; F:3-keto sterol reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0047024; F:5alpha-androstane-3beta,17beta-diol dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0004303; F:estradiol 17-beta-dehydrogenase [NAD(P)] activity; IEA:Ensembl.
DR GO; GO:0008209; P:androgen metabolic process; IEA:Ensembl.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:Ensembl.
DR GO; GO:0006703; P:estrogen biosynthetic process; IEA:Ensembl.
DR CDD; cd08941; 3KS_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042829; HSD17B7/Erg27.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR44442; 3-KETO-STEROID REDUCTASE; 1.
DR PANTHER; PTHR44442:SF1; 3-KETO-STEROID REDUCTASE/17-BETA-HYDROXYSTEROID DEHYDROGENASE 7; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
SQ SEQUENCE 334 AA; 37528 MW; 4139209357C04569 CRC64;
MQKVVLVTGA SSGVGLALCK RLLEEDEELR VCLACRNVGK AEAVRAALLA SHPTAEVSVV
QVDVSNVQSV IWAARELKQR FQRLDYVYLN AGIMPNPRLN IRALFSGLFS RKVIHMFSTA
EGLLTQEDKV TADGLQEVFE TNVFGHFILI RELEPLLCHS DSPSQLIWTS SRNARKSNFH
LEDIQHSSGQ EPYSSSKYAV DLLSVALNRN FNPRGLYSSV VCPGTMVTNM TCGILPPFVW
TLLMPIIWLL RFFANAFTLT PYNGTEALVW LFHQQPESLN PLTKYLSATT GFGSNYVTTH
KMDLDEDTAE KFYQNLLELE KHIRVTIQKT NNQS
//