GenomeNet

Database: UniProt
Entry: G1L3U6_AILME
LinkDB: G1L3U6_AILME
Original site: G1L3U6_AILME 
ID   G1L3U6_AILME            Unreviewed;       334 AA.
AC   G1L3U6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=3beta-hydroxysteroid 3-dehydrogenase {ECO:0000256|ARBA:ARBA00023621};
DE            EC=1.1.1.270 {ECO:0000256|ARBA:ARBA00023621};
GN   Name=HSD17B7 {ECO:0000313|Ensembl:ENSAMEP00000001556.2};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001556.2, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000001556.2, ECO:0000313|Proteomes:UP000008912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000001556.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha-
CC         methylzymosterol + NADP(+); Xref=Rhea:RHEA:36379, ChEBI:CHEBI:1949,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:136486; EC=1.1.1.270;
CC         Evidence={ECO:0000256|ARBA:ARBA00033683};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36380;
CC         Evidence={ECO:0000256|ARBA:ARBA00033683};
CC   -!- PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from
CC       lanosterol: step 5/6. {ECO:0000256|ARBA:ARBA00023589}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. ERG27 subfamily. {ECO:0000256|ARBA:ARBA00023593}.
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DR   RefSeq; XP_002920144.1; XM_002920098.3.
DR   AlphaFoldDB; G1L3U6; -.
DR   STRING; 9646.ENSAMEP00000001556; -.
DR   Ensembl; ENSAMET00000001616.2; ENSAMEP00000001556.2; ENSAMEG00000001450.2.
DR   GeneID; 100477716; -.
DR   KEGG; aml:100477716; -.
DR   CTD; 51478; -.
DR   eggNOG; KOG1478; Eukaryota.
DR   GeneTree; ENSGT00390000013340; -.
DR   HOGENOM; CLU_029944_2_0_1; -.
DR   InParanoid; G1L3U6; -.
DR   TreeFam; TF105433; -.
DR   UniPathway; UPA00770; UER00758.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0000253; F:3-keto sterol reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047024; F:5alpha-androstane-3beta,17beta-diol dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0004303; F:estradiol 17-beta-dehydrogenase [NAD(P)] activity; IEA:Ensembl.
DR   GO; GO:0008209; P:androgen metabolic process; IEA:Ensembl.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006703; P:estrogen biosynthetic process; IEA:Ensembl.
DR   CDD; cd08941; 3KS_SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR042829; HSD17B7/Erg27.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR44442; 3-KETO-STEROID REDUCTASE; 1.
DR   PANTHER; PTHR44442:SF1; 3-KETO-STEROID REDUCTASE/17-BETA-HYDROXYSTEROID DEHYDROGENASE 7; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912}.
SQ   SEQUENCE   334 AA;  37528 MW;  4139209357C04569 CRC64;
     MQKVVLVTGA SSGVGLALCK RLLEEDEELR VCLACRNVGK AEAVRAALLA SHPTAEVSVV
     QVDVSNVQSV IWAARELKQR FQRLDYVYLN AGIMPNPRLN IRALFSGLFS RKVIHMFSTA
     EGLLTQEDKV TADGLQEVFE TNVFGHFILI RELEPLLCHS DSPSQLIWTS SRNARKSNFH
     LEDIQHSSGQ EPYSSSKYAV DLLSVALNRN FNPRGLYSSV VCPGTMVTNM TCGILPPFVW
     TLLMPIIWLL RFFANAFTLT PYNGTEALVW LFHQQPESLN PLTKYLSATT GFGSNYVTTH
     KMDLDEDTAE KFYQNLLELE KHIRVTIQKT NNQS
//
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