ID G1L649_AILME Unreviewed; 1424 AA.
AC G1L649;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 6 {ECO:0000313|Ensembl:ENSAMEP00000002364.2};
GN Name=FGD6 {ECO:0000313|Ensembl:ENSAMEP00000002364.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000002364.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000002364.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000002364.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_019655234.1; XM_019799675.1.
DR STRING; 9646.ENSAMEP00000002364; -.
DR Ensembl; ENSAMET00000002463.2; ENSAMEP00000002364.2; ENSAMEG00000002237.2.
DR GeneID; 100471190; -.
DR CTD; 55785; -.
DR eggNOG; KOG1729; Eukaryota.
DR GeneTree; ENSGT00940000156334; -.
DR HOGENOM; CLU_004959_0_0_1; -.
DR InParanoid; G1L649; -.
DR TreeFam; TF316247; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15743; FYVE_FGD6; 1.
DR CDD; cd15793; PH1_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037743; FGD6_N_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 865..1054
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1083..1177
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1216..1275
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1327..1423
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..839
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1424 AA; 159673 MW; 87DA62A8D3E7475E CRC64;
MTSAAEIKKP PVAPKPKFVV ASNKPAPPPV APKPDIVISS VPQSTKKTKP AIAPKPKVLK
GSPVRDIRQS PSRKIIVNVE EHKQELPENA DNSNCKNVGH QSSDYILPVC SCSSQCIHKL
GNRENLCVKQ LILEPLEMHE NLENSKIDKS SSAIKTKSKC DSNVENIKSQ SGVVLKANIL
EEKLKDVLTQ RTSPFISLQK HRSTDSPETN DGYNSNRQLR IEFADLSPSL SSFEKVPDHH
HCHLQLPSDE TYQHSSEKSS TCFHSSEQEA LENGKRSTFL SSDGVSKKSE VKDLSPLEIH
LVPYTPKFPT PKPRKTRAAC LLRQKYIDVP SESTEEPESL DSNSSCLLEA GLKNNKISVL
HQNVLCNQEQ VDKVKPGNKS ELNVDSDGDR QNLVNPQKAM CPEASSFEKM ETDSNLSSDS
KTVDGSSMSL AVDKGPSFIR CSTLSMSLPK QLKLTCNEHL PATCNLGVSA PQMQKESPIK
GESSSRIVPK KPQRHSLPAA GVLKKAASEE LVEKSSYPSN EENNSEKGLE RNHLQHLCAQ
NLSMSSSFDM PKRATEKPVW KLPHPILPFS GNPESLKSVT ISSNNELSTA ITKPRAKSLS
AMDAERCNKP CKDTQKKSSL KKLLNMKLSI CFMKSDFQKF WSKNSQLGDT TAGSLSGGER
KGMESDWHGV LVEEKRSKPI KAYSADNYSL ESQKKRKKSR GQTNAANGPR AESLDDQMLS
RESSSQLPCK SITSVCAPEY ENVRHYEEIP EYENLPFILA IGKTPELEWQ NSRSLEDTDA
NVYEVEEPYE APDGRLQLGP RHQHSSSPGA SQEGHNNLDL GLGELPSDEE EDINSSDEDD
VSSDSSKGDP DLGDKQDEDT GMKSKVHHIA KEIMSSEKVF VDVLKLLHID FRDAVAHASR
QLGKPVIEDR ILNQILYYLP QLYELNRDLL KELEERMSNW TEQHRIADIF VKKGPYLKMY
STYIKEFDKN IALLDEQCKK NPAFAAVVRD FEMSPRCANL ALKHYLLKPV QRIPQYRLLL
TDYLKNLLED SGDYRDTQDA LAVVIEVANH ANDTMKQGDN FQKLMQIQYS LNGHHEIVQP
GRVFLKEGTL MKLSRKVMQP RVFFLFNDAL LYTTPVQSGM YKLNNMLSLA GMKVRKPTQE
AYQNELKIES VERSFILSAS SATERDEWLE AISRSIEEYA KKRITFCPSR SLDEADSENK
EEVSPLGSKA PIWIPDTRAT MCMICTSEFT LTWRRHHCRA CGKIVCQACS SNKYGLDYLK
NQPARVCEHC FQELQKLDHQ HSPKIGSPGN HKSPSSALSS VLHSIPSGRK QKKIPAALKE
VSANTEDSSM SGYLYRSKGN KKPWKHLWFV IKNKVLYTYA ASEDVAALES QPLLGFTVTQ
VKDENSESRV FQLLHKNMLF YVFKADDAHS AQKWIEAFQE GTIL
//
