GenomeNet

Database: UniProt
Entry: G1L6L5_AILME
LinkDB: G1L6L5_AILME
Original site: G1L6L5_AILME 
ID   G1L6L5_AILME            Unreviewed;      2002 AA.
AC   G1L6L5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   07-JUN-2017, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSAMEP00000002530};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000002530, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000002530}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000002530}.
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DR   EMBL; ACTA01003976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000002530; -.
DR   Ensembl; ENSAMET00000002641; ENSAMEP00000002530; ENSAMEG00000002310.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1L6L5; -.
DR   OMA; EGCIKKF; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    402    429       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    763    781       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    793    816       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    873    901       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    963    986       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1209   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1446   1470       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1529   1547       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1577       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1584   1609       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1646   1674       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1750   1773       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    436       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      509    712       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      763    991       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1000   1202       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1207   1478       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1528   1783       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      426    467       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2002 AA;  226748 MW;  A76B6D30D6C7060D CRC64;
     MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKRE QDNDDENKPK PNSDLEAGKN
     LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPPLNPVRK
     IAIKILLLST LFSMLIMCTI LTNCVFMTLS NPPDWTKNVE YTFTGIYTFE SLIKILARGF
     CLEDFTFLRD PWNWLDFSVI VMAYVTEFVD LGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVKKLS DVMILTVFCL SVFALIGLQL FMGNLRNKCL QWPPSDSAFD TNTTSYFNGT
     MDSNGIFVNV TMSTFNWKDY IEDDSHFYVL DGQKDPLLCG NGSDAGQCPE GYICVKAGRN
     PNYGYTSFDT FSWAFLSLFR LMTQDYWENL YQLTLRAAGK TYMIFFVLVI FLGSFYLVNL
     ILAVVAMAYE EQNQATLEEA EQKEAEFQQM LEQLKKQQEE AQAVAAASAA SRDFSGIGGL
     GELLESSSEA SKLSSKSAKE WRNRRKKRRQ REHLEGNNKG ERDRFPKSES EDSVKRRSFL
     FSMDGNRLTS DKKFYSPHQS LLSIRGSLFS PRRNSKTSIF SFRGRAKDVG SENDFADDEH
     STFEDSESRR DSLFVPHRHG ERRNSNVSQA SMSSRMVPGL PANGKMHSTV DCNGVVSLVG
     GPSALTSPTG QLPPEGTTTE TEVRKRRLSS YQISMEMMED SSGRQRAMSI ASILTNTMEE
     LEESRQKCPP CWYRFANVFL IWDCCDAWLK VKHLVNLIVM DPFVDLAITI CIVLNTLFMA
     MEHYPMTGQF SSVLTVGNLV FTGIFTAEMV LKIIAMDPYY YFQEGWNIFD GIIVSLSLME
     LGLANVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV LAIIVFIFAV
     VGMQLFGKSY KECVCKISSD CQLPRWHMND FFHSFLIVFR VLCGEWIETM WDCMEVAGQT
     MCLIVFMLVM VIGNLVVLNL FLALLLSSFS SDNLAATDDD NEMNNLQIAV GRMQKGIDYV
     KNKIRECFRK TFFRKPKVIE IHEGNKIDSC ISNNTGIEIS KELNYLKDGN GTTSGVGTGS
     SVEKYVIDEN DYMSFINNPS LTVTVPIAVG ESDFENLNTE EFSSESELEE SKEKLNATSS
     SEGSTVDVAP PREGEQAEIE PEEDLKPEAC FTEGCIKKFP FCQVSIEEGK GKVWWNLRKT
     CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT YIFILEMLLK
     WVAYGFQTYF TNAWCWLDFL IVDVSLVSLV ANALGYSELG AIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCVNTT TGNMFEVSEV
     NNLSDCQALG KQARWKNVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRDVKLQPVY
     EENLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK
     LGSKKPQKPI PRPANKFQGM VFDFVTRQVF DISIMILICL NMVTMMVETD DQSKYMTLVL
     SRINLVFIIL FTGEFVLKLI SLRYYYFTIG WNIFDFVVVI LSIVGMFLAE LIEKYFVSPT
     LFRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YAIFGMSNFA
     YVKKEAGIDD MFNFETFGNS MICLFQITTS AGWDGLLAPI LNSAPPDCDP NTIHPGSSVK
     GDCGNPSVGI FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED DFEMFYEVWE
     KFDPDATQFI EFSKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH CLDILFAFTK
     RVLGESGEMD ALRIQMEDRF MASNPSKVSY EPITTTLKRK QEEVSAAIIQ RNFRCYLLRQ
     RLKKVSSEYN KEAIKGKIDL PIKEDMIIDK LNGNSTPEKT DGSSSTTSPP SYDSVTKPDK
     EKFEKDKPEK ESKGKEVREN QK
//
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