GenomeNet

Database: UniProt
Entry: G1L857_AILME
LinkDB: G1L857_AILME
Original site: G1L857_AILME 
ID   G1L857_AILME            Unreviewed;      4911 AA.
AC   G1L857;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 43.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSAMEP00000003073};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSAMEP00000003073};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000003073, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000003073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000003073}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000003073}.
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DR   EMBL; ACTA01002487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01010487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01018487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01026487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01034487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01042486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01170480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01178478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01186476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01194474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000003073; -.
DR   Ensembl; ENSAMET00000003200; ENSAMEP00000003073; ENSAMEG00000002582.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1L857; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4224   4243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4444   4464       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4518   4537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4654   4675       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4712   4733       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4788   4811       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       55    110       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      117    162       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      170    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    353       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      544    754       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      970   1167       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1282   1507       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3967   4002       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4359   4380       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4911 AA;  558031 MW;  969908A3872B92CA CRC64;
     RMSPQTSPSA PLCWNSLSLS APCRRCWLTP WRSQKGQVDV EKWLFFPQTA QGGGHRTLLY
     GHAILLRHSY SGMYLCCLST SRSSTDKLAF DVGLQEDTTG EACWWTIHPA SKQRSEGEKV
     RVGDDLILVS VSSERYLHLS YGNGSLHVDA AFQQTLWSVA PISSGSEAAQ GYLIGGDVLR
     LLHGHMDECL TVPSGEHGEE QRRTVHYEGG AVSVHARSLW RLETLRVAWS GSHIRWGQPF
     RLRHVTTGKY LSLMEDKSLL LMDKEKADVK STAFTFRSSK EKLDVGVRKE VDGMGTSEIK
     YGDSVCYIQH INTGLWLTYQ SVDVKSVRMG SIQRKAIMHH EGHMDDGLNL SRSQHEESRT
     ARVIRSTVFL FNRFIRGLDA LSKKVKASTV DLPIESVSLS LQDLIGYFHP PDEHLEHEDK
     QNRLRALKNR QNLFQEEGMI NLVLECIDRL HVYSSAAHFA DVAGREAGES WKSILNSLYE
     LLAALIRGNR KNCAQFSGSL DWLISRLERL EASSGILEVL HCVLVESPEA LNIIKEGHIK
     SIISLLDKHG RNHKVLDVLC SLCVCHGVAV RSNQHLICDN LLPGRDLLLQ TRLVNHVSSM
     RPNIFLGVSE GSAQYKKWYY ELMVDHTEPF VTAEATHLRV GWASTEGYSP YPGGGEEWGG
     NGVGDDLFSY GFDGLHLWSG CIARTVSSPN QHLLRTDDVI SCCLDLSAPS ISFRINGQPV
     QGMFENFNID GLFFPVVSFS AGIKVRFLLG GRHGEFKFLP PPGYAPCYEA VLPKEKLKVE
     HSREYKQERT YTRDLLGPTV SLTQAAFTPI PVDTSQIVLP PHLERIREKL AENIHELWVM
     NKIELGWQYG PVRDDNKRQH PCLVEFSKLP EQERNYNLQM SLETLKTLLA LGCHVGISDE
     HAEEKVKKMK LPKNYQLTSG YKPAPMDLSF IKLTPSQEAM VDKLAENAHN VWARDRIRQG
     WTYGIQQDVK NRRNPRLVPY ALLDDRTKKS NKDSLREAVR TLLGYGYNLE APDQDPGARA
     EVCSGTGERF RIFRAEKTYA VKAGRWYFEF EAVTAGDMRV GWSRPGCQPD QELGSDERAF
     AFDGFKAQRW HQGNEHYGRS WQAGDVVGCM VDMTEHTMLF TLNGEILLDD SGSELAFKDF
     DVGDGFIPVC SLGVAQVGRM NFGKDVSTLK YFTICGLQEG YEPFAVNTNR DITMWLSKRL
     PQFLQVPSNH EHIEVTRIDG TIDSSPCLKV TQKSFGSQNS STDIMFYRLS MPIECAEVFS
     KTVAGGLPGA GLFGPKNDLE DYDADSDFEV LMKTAHGHLV PDRVDKDKEA TKPEFNNHKD
     YAQEKPSRLK QRFLLRRTKP DYSTSHSARL TEDVLADDRD DYDYLMQTST YYYSVRIFPG
     QEPANVWVGW ITSDFHQYDT GFDLDRVRTV TVTLGDEKGK VHESIKRSNC YMVCAGESMS
     PGQGRNNNGL EIGCVVDAAS GLLTFTANGK ELGTYYQVEP STKLFPAVFA QATSPNVFQF
     ELGRIKNVMP LSAGLFKSEH KNPVPQCPPR LHVQFLSHVL WSRMPNQFLK VDVSRISERQ
     GWLVQCLDPL QFMSLHIPEE NRSVDILELT EQEELLKFHY HTLRLYSAVC ALGNHRVAHA
     LCSHVDEPQL LYAIENKYMP GLLRAGYYDL LIDIHLSSYA TARLMMNSEF IVPMTEETKS
     ITLFPDENKK HGLPGIGLST SLRPRIQFSS PSFVSINNEC YQYSPEFPLD ILKAKTIQML
     TEAVKEGSLH ARDPVGGTTE FLFVPLIKLF YTLLIMGIFH NEDLKHILRL IEPSVFKEAA
     TPDEETDVLE KEPSPEDARP EGAGEEEAKG GKRPKEGLLQ MKLPEPVKLQ MCLLLQYLCD
     CQVRHRIEAI VAFSDDFVAK LQDNQRFRYN EVMQALNMSA ALTARKTKEF RSPPQEQINM
     LLNFKDDKSE CPCPEEIRDQ LLDFHEDLMT HCGIELDEDG SLDGNSDLTI RGRLLSLVEK
     VTYLKKKQAE KPVESDSKKS STLQQLISET MVRWAQESVI EDPELVRAMF VLLHRQYDGI
     GGLVRALPKT YTINGVSVED TINLLASLGQ IRSLLSVRMG KEEEKLMIRG LGDIMNNKVF
     YQHPNLMRAL GMHETVMEVM VNVLGGGESK EITFPKMVAN CCRFLCYFCR ISRQNQKAMF
     DHLSYLLENS SVGLASPAMR GSTPLDVAAA SVMDNNELAL ALREPDLEKV VRYLAGCGLQ
     SCQMLVSKGY PDIGWNPVEG ERYLDFLRFA VFCNGESVEE NANVVVRLLI RRPECFGPAL
     RGEGGNGLLA AMEEAIKIAE DPSRDGPSPT SGSSKTLDTE EEEDDTIHMG NAIMTFYAAL
     IDLLGRCAPE MHLIHAGKGE AIRIRSILRS LIPLGDLVGV ISIGFQMPTI AKDGNVVEPD
     MSAGFCPDHK AAMVLFLDRV YGIEVQDFLL HLLEVGFLPD LRAAASLDTA ALSATDMALA
     LNRYLCTAVL PLLTRCAPLF AGTEHHASLI DSLLHTVYRL SKGCSLTKAQ RDAIEICLLS
     ICGQLRPSMM QHLLRRLVFD VPLLNEHAKM PLKLLTNHYE RCWKYYCLPG GWGNFGAASE
     EELHLSRKLF WGIFDALSQK KYEQELFKLA LPCLSAVAGA LPPDYMESNY VSMMEKQSSM
     DSEGNFNPQP VDTSNITIPE KLEYFINKYA EHSHDKWSMD KLANGWIYGE IYSDSSKVQP
     LMKPYKLLSE KEKEIYRWPI KESLKTMLAW GWRIERTREG DSMALYNRTR RISQTSQVSV
     DAAHGYSPRA IDMSNVTLSR DLHAMAEMMA ENYHNIWAKK KKMELESKGG GNHPLLVPYD
     TLTAKEKAKD REKAQDILKF LQINGYAVSR GFKDLELDTP SIEKRFAYSF LQQLIRYVDE
     AHQYILEFDG GSRSKGEHFP YEQEIKFFAK VVLPLIDQYF KNHRLYFLSA ASRPLCSGGH
     ASNKEKEMVT SLFCKLGVLV RHRISLFGND ATSIVNCLHI LGQTLDARTV MKTGLESVKS
     ALRAFLDNAA EDLEKTMENL KQGQFTHTRN QPRGVTQIIN YTTVALLPML SSLFEHIGQH
     QFGEDLILED VQVSCYRILT SLYALGTSKS IYVERQRSAL GECLAAFAGA FPVAFLETHL
     DKHNVYSIYN TKSSRERAAL NLPTNVEDVC PNIPSLEKLM EEIVELAESG IRYTQMPHVM
     EVILPMLCSY MSRWWEHGPE NNPERAEMCC TALSSEHMNT LLGNILKIIY NNLGIDEGAW
     MKRLAVFSQP IINKVKPQLL KTHFLPLMEK LKKKAAMVVS EEDHLKAEAR GDMSEAELLI
     LDEFTTLARD LYAFYPLLIR FVDYNRAKWL KEPNPEAEDL FRMVAEVFIY WSKSHNFKRE
     EQNFVVQNEI NNMSFLITDT KSKMSKAAVS DQERKKMKRR GDRYSMQTSL IVAALKRLLP
     IGLNICAPGD QELIALAKNR FSMKDTEDEV RDIIRSNIHL QGKLEDPAIR WQMALYKDLP
     NRTEDTSDPE KTVERVLDIA NVLFHLEQIF KFFGIILPQV EHPQRSKKAV WHKLLSKQRK
     RAVVACFRMA PLYNLPRHRA VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGANPPEEEE
     GTKRVDPLHQ LILLFSRTAL TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE
     KEMEKQKLLY QQARLHDRGA AEMVLQTISA SKGDTGPMVA ATLKLGIAIL NGGNSTVQQK
     MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT
     CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD
     VIDEQGQRNF SKAIQVAKQV FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM
     KLSQDSSQIE LLKELMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF
     FDMFLKLKDL TSSDTFKEYD PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE
     TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI
     EIMGSAKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT
     IFEMQLAAQI SESDLNERSV NKDESEKEKP EEQGPRMGFF SILTVKSALL ALRYNILTLM
     RMLTLKSLKK QMKKVKKMTV KDMVTAAFSS YWSIFLSLLH FVASVSRGFF RIVCSLLLGG
     SLVEGAKKIR VAELLANMPD PTQDEVRGDG EEGDRKPMEA ALPSEDLTDL KELTEESDLL
     SDIFGLDLKR EGGQYKLIPH NPNAGLSDLM SNPVAIPDVQ EKFQEQKAKE DEKEEKEENK
     SEPEKAEGED GEKEEKAKED KGKQKLRQLH MHRYGEPEVP ESAFWKKIIA YQQKLLNYFA
     RNFYNMRMLA LFVAFAINFI LLFYKVSTSS VVEGKELPTR STSENAKVSS LDSGSPRIMA
     VHYVLEESSG YMEPTLKILA ILHTVISFFC IIGYYCLKVP LVIFKREKEV ARKLEFDGLY
     ITEQPSEDDI KGQWDRLVIN TQSFPNNYWD KFVKRKVMDK YGEFYGRDRI SELLGMDKAA
     LDFSDAREKK KPKKDSSLSA VLNSIDVKYQ MWKLGVVFTD NSFLYLAWYM TMSVLGHYNN
     FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS
     EDGDTPDMKC DDMLTCYMFH MYVGVRAGGG IGDEIEDPAG DEYEIYRIIF DITFFFFVIV
     ILLAIIQGLI IDAFGELRDQ QEQVKEDMET KCFICGIGND YFDTVPHGFE THTLQEHNLA
     NYLFFLMYLI NKDETEHTGQ ESYVWKMYQE RCWEFFPAGD CFRKQYEDQL N
//
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