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Database: UniProt
Entry: G1L869_AILME
LinkDB: G1L869_AILME
Original site: G1L869_AILME 
ID   G1L869_AILME            Unreviewed;      3618 AA.
AC   G1L869;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSAMEP00000003085};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSAMEP00000003085};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000003085, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000003085}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000003085}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000003085}.
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DR   EMBL; ACTA01002487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01010487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01018487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01026487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01034487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01042486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01170480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01178478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01186476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01194474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMET00000003212; ENSAMEP00000003085; ENSAMEG00000002582.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN       11     66       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       73    118       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      126    181       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      187    244       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      252    309       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      500    710       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      926   1123       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1238   1463       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   3618 AA;  409630 MW;  F836C9C64195B3B0 CRC64;
     FFPQTAQGGG HRTLLYGHAI LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW
     WTIHPASKQR SEGEKVRVGD DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS
     GSEAAQGYLI GGDVLRLLHG HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET
     LRVAWSGSHI RWGQPFRLRH VTTGKYLSLM EDKSLLLMDK EKADVKSTAF TFRSSKEKLD
     VGVRKEVDGM GTSEIKYGDS VCYIQHINTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM
     DDGLNLSRSQ HEESRTARVI RSTVFLFNRF IRGLDALSKK VKASTVDLPI ESVSLSLQDL
     IGYFHPPDEH LEHEDKQNRL RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG
     REAGESWKSI LNSLYELLAA LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL
     VESPEALNII KEGHIKSIIS LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG
     RDLLLQTRLV NHVSSMRPNI FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS
     TEGYSPYPGG GEEWGGNGVG DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL
     DLSAPSISFR INGQPVQGMF ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY
     APCYEAVLPK EKLKVEHSRE YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE
     RIREKLAENI HELWVMNKIE LGWQYGPVRD DNKRQHPCLV EFSKLPEQER NYNLQMSLET
     LKTLLALGCH VGISDEHAEE KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL
     AENAHNVWAR DRIRQGWTYG IQQDVKNRRN PRLVPYALLD DRTKKSNKDS LREAVRTLLG
     YGYNLEAPDQ DPGARAEVCS GTGERFRIFR AEKTYAVKAG RWYFEFEAVT AGDMRVGWSR
     PGCQPDQELG SDERAFAFDG FKAQRWHQGN EHYGRSWQAG DVVGCMVDMT EHTMLFTLNG
     EILLDDSGSE LAFKDFDVGD GFIPVCSLGV AQVGRMNFGK DVSTLKYFTI CGLQEGYEPF
     AVNTNRDITM WLSKRLPQFL QVPSNHEHIE VTRIDGTIDS SPCLKVTQKS FGSQNSSTDI
     MFYRLSMPIE CAEVFSKTVA GGLPGAGLFG PKNDLEDYDA DSDFEVLMKT AHGHLVPDRV
     DKDKEATKPE FNNHKDYAQE KPSRLKQRFL LRRTKPDYST SHSARLTEDV LADDRDDYDY
     LMQTSTYYYS VRIFPGQEPA NVWVGWITSD FHQYDTGFDL DRVRTVTVTL GDEKGKVHES
     IKRSNCYMVC AGESMSPGQG RNNNGLEIGC VVDAASGLLT FTANGKELGT YYQVEPSTKL
     FPAVFAQATS PNVFQFELGR IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM
     PNQFLKVDVS RISERQGWLV QCLDPLQFMS LHIPEENRSV DILELTEQEE LLKFHYHTLR
     LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR AGYYDLLIDI HLSSYATARL
     MMNSEFIVPM TEETKSITLF PDENKKHGLP GIGLSTSLRP RIQFSSPSFV SINNECYQYS
     PEFPLDILKA KTIQMLTEAV KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL
     KHILRLIEPS VFKEAATPDE ETDVLEKEPS PEDARPEGAG EEEAKGGKRP KEGLLQMKLP
     EPVKLQMCLL LQYLCDCQVR HRIEAIVAFS DDFVAKLQDN QRFRYNEVMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLLNF KDDKSECPCP EEIRDQLLDF HEDLMTHCGI ELDEDGSLDG
     NSDLTIRGRL LSLVEKVTYL KKKQAEKPVE SDSKKSSTLQ QLISETMVRW AQESVIEDPE
     LVRAMFVLLH RQYDGIGGLV RALPKTYTIN GVSVEDTINL LASLGQIRSL LSVRMGKEEE
     KLMIRGLGDI MNNKVFYQHP NLMRALGMHE TVMEVMVNVL GGGESKEITF PKMVANCCRF
     LCYFCRISRQ NQKAMFDHLS YLLENSSVGL ASPAMRGSTP LDVAAASVMD NNELALALRE
     PDLEKVVRYL AGCGLQSCQM LVSKGYPDIG WNPVEGERYL DFLRFAVFCN GESVEENANV
     VVRLLIRRPE CFGPALRGEG GNGLLAAMEE AIKIAEDPSR DGPSPTSGSS KTLDTEEEED
     DTIHMGNAIM TFYAALIDLL GRCAPEMHLI HAGKGEAIRI RSILRSLIPL GDLVGVISIG
     FQMPTIAKDG NVVEPDMSAG FCPDHKAAMV LFLDRVYGIE VQDFLLHLLE VGFLPDLRAA
     ASLDTAALSA TDMALALNRY LCTAVLPLLT RCAPLFAGTE HHASLIDSLL HTVYRLSKGC
     SLTKAQRDAI EICLLSICGQ LRPSMMQHLL RRLVFDVPLL NEHAKMPLKL LTNHYERCWK
     YYCLPGGWGN FGAASEEELH LSRKLFWGIF DALSQKKYEQ ELFKLALPCL SAVAGALPPD
     YMESNYVSMM EKQSSMDSEG NFNPQPVDTS NITIPEKLEY FINKYAEHSH DKWSMDKLAN
     GWIYGEIYSD SSKVQPLMKP YKLLSEKEKE IYRWPIKESL KTMLAWGWRI ERTREGDSMA
     LYNRTRRISQ TSQVSVDAAH GYSPRAIDMS NVTLSRDLHA MAEMMAENYH NIWAKKKKME
     LESKGGGNHP LLVPYDTLTA KEKAKDREKA QDILKFLQIN GYAVSSFRGF KDLELDTPSI
     EKRFAYSFLQ QLIRYVDEAH QYILEFDGGS RSKGEHFPYE QEIKFFAKVV LPLIDQYFKN
     HRLYFLSAAS RPLCSGGHAS NKEKEMVTSL FCKLGVLVRH RISLFGNDAT SIVNCLHILG
     QTLDARTVMK TGLESVKSAL RAFLDNAAED LEKTMENLKQ GQFTHTRNQP RGVTQIINYT
     TVALLPMLSS LFEHIGQHQF GEDLILEDVQ VSCYRILTSL YALGTSKSIY VERQRSALGE
     CLAAFAGAFP VAFLETHLDK HNVYSIYNTK SSRERAALNL PTNVEDVCPN IPSLEKLMEE
     IVELAESGIR YTQMPHVMEV ILPMLCSYMS RWWEHGPENN PERAEMCCTA LSSEHMNTLL
     GNILKIIYNN LGIDEGAWMK RLAVFSQPII NKVKPQLLKT HFLPLMEKLK KKAAMVVSEE
     DHLKAEARGD MSEAELLILD EFTTLARDLY AFYPLLIRFV DYNRAKWLKE PNPEAEDLFR
     MVAEVFIYWS KSHNFKREEQ NFVVQNEINN MSFLITDTKS KMSKAAVSDQ ERKKMKRRGD
     RYSMQTSLIV AALKRLLPIG LNICAPGDQE LIALAKNRFS MKDTEDEVRD IIRSNIHLQG
     KLEDPAIRWQ MALYKDLPNR TEDTSDPEKT VERVLDIANV LFHLEQKSTC MRRRYYSLVE
     HPQRSKKAVW HKLLSKQRKR AVVACFRMAP LYNLPRHRAV NLFLQGYEKS WIETEEHYFE
     DKLIEDLAKP GANPPEEEEG TKRVDPLHQL ILLFSRTALT EKCKLEEDFL YMAYADIMAK
     SCHDEEDDDG EEEVKSFE
//
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