ID G1LDL3_AILME Unreviewed; 439 AA.
AC G1LDL3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=tRNA methyltransferase O {ECO:0000313|Ensembl:ENSAMEP00000004995.2};
GN Name=TRMO {ECO:0000313|Ensembl:ENSAMEP00000004995.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000004995.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000004995.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000004995.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tRNA methyltransferase O family.
CC {ECO:0000256|ARBA:ARBA00033753}.
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DR RefSeq; XP_002914978.1; XM_002914932.3.
DR AlphaFoldDB; G1LDL3; -.
DR STRING; 9646.ENSAMEP00000004995; -.
DR Ensembl; ENSAMET00000005199.2; ENSAMEP00000004995.2; ENSAMEG00000004735.2.
DR GeneID; 100472408; -.
DR KEGG; aml:100472408; -.
DR CTD; 51531; -.
DR eggNOG; KOG2942; Eukaryota.
DR GeneTree; ENSGT00390000004643; -.
DR HOGENOM; CLU_013458_1_0_1; -.
DR InParanoid; G1LDL3; -.
DR TreeFam; TF331670; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0089715; F:tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity; IEA:Ensembl.
DR GO; GO:0030488; P:tRNA methylation; IEA:Ensembl.
DR CDD; cd09281; UPF0066; 1.
DR Gene3D; 2.40.30.70; YaeB-like; 1.
DR Gene3D; 3.30.2310.10; YaeB-like; 1.
DR InterPro; IPR023370; TrmO-like_N.
DR InterPro; IPR023368; UPF0066_cons_site.
DR InterPro; IPR040372; YaeB-like.
DR InterPro; IPR036413; YaeB-like_sf.
DR InterPro; IPR036414; YaeB_N_sf.
DR NCBIfam; TIGR00104; tRNA_TsaA; 1.
DR PANTHER; PTHR12818:SF0; TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12818; UNCHARACTERIZED; 1.
DR Pfam; PF01980; TrmO; 1.
DR SUPFAM; SSF118196; YaeB-like; 2.
DR PROSITE; PS01318; TSAA_1; 1.
DR PROSITE; PS51668; TSAA_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 30..168
FT /note="TsaA-like"
FT /evidence="ECO:0000259|PROSITE:PS51668"
FT REGION 179..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 48696 MW; 27EC28DF206855CC CRC64;
MRVLEEPGSQ PTATPCGCVK PALETGNLLT EPIGYLESCF SAKNGTPRQP SICSHSRACL
RIRKSIFNNP EHSLMGLEQF SHVWVLFVFH KNGHLSCKAK VQPPRLNGAK TGVFSTRSPH
RPNAIGLTLA KLEKVEGGAM YLSGIDMIHG TPVLDIKPYI AEYDSPQNLI EPLQDFNLQN
SQYKPPNTSQ ANGKTDSCDQ RQLSRCDKPQ ACSHTKEKPK CPEDRTSGEN YMKHDNSTKI
QQKFPQHREI AADLGLESRS DQSLSVAEER IGPCCLEKSI SEEDTEKRLT VIAQGNSAEM
HPVAPPCPSR MADAARHSVV PAWVREAPVA TLEVRFTPHA ETDLKRLSSE GEPDGSQPSF
KYFQSAEEAR HAIEAMLSAD PRSVYRRKLC QDRLFYFTVD IAHVTCWFGD GFAEVLRIKP
ASEPVQMTDP EESLVSLGS
//
