ID G1LDQ7_AILME Unreviewed; 764 AA.
AC G1LDQ7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 2 {ECO:0000313|Ensembl:ENSAMEP00000005039.2};
GN Name=TRPV2 {ECO:0000313|Ensembl:ENSAMEP00000005039.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000005039.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000005039.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005039.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G1LDQ7; -.
DR STRING; 9646.ENSAMEP00000005039; -.
DR Ensembl; ENSAMET00000005246.2; ENSAMEP00000005039.2; ENSAMEG00000004724.2.
DR eggNOG; KOG3676; Eukaryota.
DR GeneTree; ENSGT00940000158512; -.
DR HOGENOM; CLU_012795_1_1_1; -.
DR InParanoid; G1LDQ7; -.
DR TreeFam; TF314711; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0044295; C:axonal growth cone; IEA:Ensembl.
DR GO; GO:0044297; C:cell body; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0032584; C:growth cone membrane; IEA:Ensembl.
DR GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR GO; GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
DR GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0009266; P:response to temperature stimulus; IEA:Ensembl.
DR CDD; cd22197; TRPV2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 391..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 160..192
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 391..654
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 85492 MW; 0DCC69EA8AFCD31F CRC64;
MASPSSPLAF RLQISDGGQE DGGEVDKGGR GDGPPPMESP FQGEDRNSSP QIKVNLNYRK
RAGVSQPDPN RFDRDRLFSV VARGVPEDLA GLPEYLSRTS KYLTDSEYTE GSTGKTCLMK
AVLNLRDGAN ACILPLLQID RDSGNPQPLV NAQCTDEYYR GHSALHIAIE KRSLQCVKLL
VENGANVHAR ACGHFFQKKS QGTCFYFGEL PLSLAACTKQ WDVVTYLLEN PHQPASLQAA
DSLGNTVLHA LVMIADNSAE NSALVIRMYD GLLRTGARLC PTVQLEDIPN LQGLTPLKLA
AKEGKIEIFR HILQREFSGP CQSLSRKFTE WCYGPVRVSL YDLASVDSWE ENSVLEIIAF
HCRSPHRHRM VVLEPLNKLL QAKWDLLIPK FFFNFLCYLT YMLLFTAVAY HQPALEKQPF
FPPKVTAGDS MLLLGHILIL LGGVYLLVGQ LWYFWRRRLF IWISFVDSYF ELLFLAQALL
MVLSQALCFL AVEWYLPLLV SSLVLGWLNL LYYTRGLQHT GIYSVMIQKV ILRDLLRFLL
VYLVFLFGFA VALVSLSREA RAPGVPTGPN VTEAVQPGAG QTDEEGSAPP YGSILDASLE
LFKFTIGMGE LAFQDQLRFR GVVLLLLLAY VLLTYILLLN MLIALMSETV NSVATDSWSI
WKLQKAISVL EMENGYWWCR RKKQPAGVKL TIGTRPDGSP DERWCFRVEE VNWAAWEQTL
PTVCEEPSGP AVPGTLKNPA PASQLEEDTA SEEDQLPLQL LKSQ
//