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Database: UniProt
Entry: G1LIT2_AILME
LinkDB: G1LIT2_AILME
Original site: G1LIT2_AILME 
ID   G1LIT2_AILME            Unreviewed;       838 AA.
AC   G1LIT2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   05-JUL-2017, entry version 31.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSAMEP00000006836};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000006836, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000006836}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000006836}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000006836}.
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DR   EMBL; ACTA01108009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01116009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01124009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01132009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01140009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01148008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01156007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_019658278.1; XM_019802719.1.
DR   Ensembl; ENSAMET00000007122; ENSAMEP00000006836; ENSAMEG00000006373.
DR   GeneID; 100470696; -.
DR   CTD; 535; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    563       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    569    593       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    634    658       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    742    765       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    771    794       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   838 AA;  96365 MW;  264CE41D06B6DD0F CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
     NFLELTELKF ILRKTQQFFD EMADPDLLEE SSSLLEPSEM GRGTPLRLGF VAGVINRERI
     PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF
     RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT
     PPTYNKTNKF TYGFQNIVDA YGIGTYREIN PAPYTIITFP FLFAVMFGDF GHGILMTLFA
     VWMVLRESRI LSQKNENEMF STVFSGRYII LLMGVFSIYT GLIYNDCFSK SLNIFGSSWS
     VRPMFTLYNW TDETLRGNPV LQLNPSVRGV FGGPYPFGID PIWNIATNKL TFLNSFKMKT
     SVILGIIHMM FGVTLSLFNH TYFKKPLNIY FGFIPEIIFM TSLFGYLVIL IFYKWTAYNA
     NTSEKAPSLL IHFINMFLFS YGDSSNSMLY SGQKGIQCFL VVVALLCVPW MLLFKPLVLR
     HQYLRRKHLG TLNFGGIRVG NGPTEEDAEI IQHDQLSTHS EDAEEPTEDE VFDFGDTMVH
     QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV IHIGLSVKSL AGGLALFFIF
     AAFATLTVAI LLIMEGLSAF LHALRLHWVE FQNKFYSGTG FKFLPFSFEH IREGKFDE
//
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