ID G1LKK8_AILME Unreviewed; 1106 AA.
AC G1LKK8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
GN Name=SMC5 {ECO:0000313|Ensembl:ENSAMEP00000007474.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000007474.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000007474.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000007474.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC {ECO:0000256|ARBA:ARBA00010171}.
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DR RefSeq; XP_002914785.1; XM_002914739.3.
DR STRING; 9646.ENSAMEP00000007474; -.
DR Ensembl; ENSAMET00000007789.2; ENSAMEP00000007474.2; ENSAMEG00000007051.2.
DR Ensembl; ENSAMET00000041329.1; ENSAMEP00000033140.1; ENSAMEG00000007051.2.
DR GeneID; 100484487; -.
DR KEGG; aml:100484487; -.
DR CTD; 23137; -.
DR eggNOG; KOG0979; Eukaryota.
DR GeneTree; ENSGT01100000263674; -.
DR HOGENOM; CLU_004969_1_0_1; -.
DR TreeFam; TF105708; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR027131; SMC5.
DR PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 57..1057
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 240..424
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 656..752
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 894..931
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 129104 MW; 0F0C80E496B27353 CRC64;
MATPSRKTSA PSTLASKRAL PRDPSSEVPS KRKSSAPPAA PPPLPLQSSR PFVEGSIVRI
VMENFLTYDV CEVSPGPHLN MIIGANGTGK SSIVCAICLG LAGKPAFMGR ADKVGFFVKR
GCSKGMVEIE LFRTSGNLVI TREIDVAKNQ SSWFINKKST TQKVVEEQVA ALNIQVGNLC
QFLPQDKVGE FAKLSKIELL EATEKSIGPP EMHRYHCELK NFREKEKQLE TSCKEKTEYL
EKMIQRNERY KQDVERFYER KRHLDLIEML EAKRPWVEYE NVRQEYEEVK LARDRAKEEV
RKLKEGQIPI TRRMEEIEKQ RHVLEARIKE KATDIKETSQ KCKQKQDIIE KKDKQIEELQ
QALTVKQNEE HDRQRRISNT RKMIEDLQNE LKSAENCENL QPQIDAITND LRRVQDEKAL
CEGEVIDKRG EKESLEKERK SVGDNIVRFD NLMNQKEDKL RQRYRDTYDA VLWLRNNRDK
FKQRVCEPIM LTINMKDNKN AKYIENHISS NDLRAFVFES QEDMEVFLKE IRDNKKLRVN
AVIAPKSSYA DKAPSRSLNE LKQYGFFSYL RELFDAPDPV MSFLCCHYHI HEVPVGTERT
RERIERVIQE TRLKQMYTAE EKYVVKTSFY SNKVISSNTS LKVAQFLTVT VDLEQRRHLE
EQLKEINRKL QAVEAGLIAL CERNKHLEHK DNELRQKKKE LLERKTKKRQ LEQKISSKLG
SLKLMEQDAC NLEEEERKAS TKIREINVQK AKLVTELTNF VKICTSLHIQ KVDLILQNTT
VISENNKLES DYMAASSQLR VTEQHFIELD ESRQRLLQKC KELMKRARQV CNLGAEQTVP
QEYQTQVPTI PNGHNSSPPM AFQDLPNTLD EIDALLTEER SRASCFTGLN PTVVEEYTKR
EEEIEQLTEE LKIKKVELDK YKENISQVKE RWLNPLKELV EKINEKFSNF FSSMQCAGEV
DLHTENEEDY DKYGIRIRVK FRSSTQLHEL TPHHQSGGER SVSTMLYLMA LQELNRCPFR
VVDEINQGMD PINERRVFEM VVNTACKENT SQYFFITPKL LQNLPYSEKM TVLFVYNGPH
MLEPNRWNLK AFQRRRRRIT FTQPSQ
//
