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Database: UniProt
Entry: G1LM85_AILME
LinkDB: G1LM85_AILME
Original site: G1LM85_AILME 
ID   G1LM85_AILME            Unreviewed;      2143 AA.
AC   G1LM85;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-SEP-2017, entry version 46.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1E {ECO:0000313|Ensembl:ENSAMEP00000008073};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000008073, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000008073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000008073}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000008073}.
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DR   EMBL; ACTA01130539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01138539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01146538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01154537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01162536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000008073; -.
DR   Ensembl; ENSAMET00000008408; ENSAMEP00000008073; ENSAMEG00000007637.
DR   eggNOG; ENOG410INF5; Eukaryota.
DR   eggNOG; ENOG410YD06; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G1LM85; -.
DR   OMA; RRRHHMS; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF253; PTHR10037:SF253; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     55     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    129    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    311    331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    437    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    984   1003       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1056   1073       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1119   1141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1231   1256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1312   1330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1342   1365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1371   1389       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1436   1454       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1529   1553       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1569   1604       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      533    560       {ECO:0000256|SAM:Coils}.
FT   COILED      929    956       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2143 AA;  242331 MW;  F6C9A64EFE7C2DE3 CRC64;
     VSICSILATA GTHFNTHVDL RTLRAVRVLR PLKLVSGIPS LQIVLKSIMK AMVPLLQIGL
     LLFFAILMFA IIGLEFYSGK LHRACFTNNS GILEGFDPPH PCGVQGCPAG YECRDWIGPN
     DGITQFDNIL FAVLTVFQCI TMEGWTTVLY NTNDALGATW NWLYFIPLII IGSFFVLNLV
     LGVLSGEFAK ERERVENRRA FMKLRRQQQI ERELNGYRAW IDKAEEVMLA EENKNAGTSA
     LEVLRRATIK RSRTEAMTRD SSDEHCVDIS SVGTPLARAS IKSAKVDGAS YFRHKERLLR
     ISIRHMVKSQ VFYWIVLSLV ALNTACVAIV HHNQPQWLTH LLYYAEFLFL GLFLLEMSLK
     MYGMGPRLYF HSSFNCFDFG VTVGSIFEVV WAIFRPGTSF GISVLRALRL LRIFKITKYW
     ASLRNLVVSL MSSMKSIISL LFLLFLFIVV FALLGMQLFG GRFNFNDGTP SANFDTFPAA
     IMTVFQILTG EDWNEVMYNG IRSQGGVSSG MWSAIYFIVL TLFGNYTLLN VFLAIAVDNL
     ANAQELTKDE QEEEEAFNQK HALQKAKEVS PMSAPNMPSI ERDRRRRHHM SMWEPRSSHL
     RERRRRHHMS VWEQRTSQLR RHMQMSSQEA LNKEEAPPMN PLNPLNPLSP LNPLNAHPSL
     YRRPRPIEGL GLGLEKCEEE RISRGGSLKG DGGDLSSALD NQRSPLSLGK REPPWLTRPC
     HGNCDPTQQE AGGGETVVTF EDRARHRQSQ RRSRHRRVRT ESKELSSTSR SRSASQERSL
     DEGVPTEGEK DREPRGSHAG KEPTIQEERG QDLRRTNSLM VPRGSGLAGA LDEANTPLVL
     AQPELEVGKD TALTEQEAEG SSEQALLGDV QLDMGRAISR SEPDLSCTTA NTDKATTDST
     SVTVAIPDVG PLVDSTVVHI SNKTDGEASP LKEAEIKEEE EEVEKKQQKK EKRETGKAMV
     PHSSMFIFST TNPIRRACHY IVSLRYFEMC ILLVIAASSI ALAAEDPVLT NSERNKVLRY
     FDYVFTGVFT FEMVIKMIDQ GLILQDGSYF RDLWNILDFV VVVGALVAFA LAVRTNKGRD
     IKTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM FIFAVIAVQL
     FKGKFFYCTD SSKDTEKECI GNYVDHEKNK MEVKGREWKR HEFHYDNIIW ALLTLFTVST
     GEGWPQVLQH SVDVTEEDRG PSRSNRMEMS IFYVVYFVVF PFFFVNIFVA LIIITFQEQG
     DKMMEECSLE KNERACIDFA ISAKPLTRYM PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL
     NTVVLMMKYY SAPCTYELAL KYLNIAFTMV FSLECVLKII AFGFLNYFRD TWNIFDFITV
     IGSITEIILT DSKLVNTSGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF VQSFKALPYV
     CLLIAMLFFI YAIIGMQVFG NIKLDEESHI NRHNNFRSFF GSLMLLFRSA TGEAWQEIML
     SCLGEKGCEP DTTAPSGQNE NERCGTDLAY VYFVSFIFFC SFLMLNLFVA VIMDNFEYLT
     RDSSILGPHH LDEFVRVWAE YDRAACGRIH YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL
     VLMNMPVAED MTVHFTSTLM ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM
     LDLLVPMPKA SDLTVGKIYA AMMIMDYYKQ SKVKKQRQQL EEQKNAPMFQ RMEPSSLPQE
     IIANAKALPY LQQDPVSGLS GHSGYPSMSP LSPQEIFQLA CMDPADDGQF QEQQSLEPEV
     SELKSVQSSS HGIYLPSDTQ EHTGSGRASS MPRLTVDPQV VTDPSSMRRS FSTIRDKRSN
     SSWLEEFSME RSSENTYKSR RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK
     HLLSPDVSRC NSEERGTQAD WESPERQQSR SPSEGRSQTP NRQGTGSLSE SSIPSVSDTS
     TPRRSRRQLP PVPPKPRPLL SYSSLLRHTG SISPPADGSE GGSPLTSQAL ESTEPGLVEA
     SSSRHVPQGQ HSSPQRYISE PYLALHEDSH ASDCGEEETL TFEAAMATSL GRSNTIGSAP
     PLRHSWQMPN GHYRRRRRGG PGPGVMCGAV SDLLSDTEED DKC
//
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