ID G1LPQ4_AILME Unreviewed; 940 AA.
AC G1LPQ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=RNA binding motif protein 19 {ECO:0000313|Ensembl:ENSAMEP00000009034.2};
GN Name=RBM19 {ECO:0000313|Ensembl:ENSAMEP00000009034.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009034.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000009034.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000009034.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1LPQ4; -.
DR STRING; 9646.ENSAMEP00000009034; -.
DR Ensembl; ENSAMET00000009419.2; ENSAMEP00000009034.2; ENSAMEG00000008544.2.
DR eggNOG; KOG0110; Eukaryota.
DR GeneTree; ENSGT00840000129953; -.
DR HOGENOM; CLU_008479_1_0_1; -.
DR InParanoid; G1LPQ4; -.
DR TreeFam; TF105725; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0040019; P:positive regulation of embryonic development; IEA:Ensembl.
DR CDD; cd12564; RRM1_RBM19; 1.
DR CDD; cd12502; RRM2_RMB19; 1.
DR CDD; cd12567; RRM3_RBM19; 1.
DR CDD; cd12569; RRM4_RBM19; 1.
DR CDD; cd12318; RRM5_RBM19_like; 1.
DR CDD; cd12571; RRM6_RBM19; 1.
DR Gene3D; 3.30.70.330; -; 6.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034419; RBM19_RRM3.
DR InterPro; IPR034420; RBM19_RRM4.
DR InterPro; IPR034423; RBM19_RRM5.
DR InterPro; IPR034421; RBM19_RRM6.
DR InterPro; IPR034418; RMB19_RRM1.
DR InterPro; IPR034417; RMB19_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR48039; RNA-BINDING MOTIF PROTEIN 14B; 1.
DR PANTHER; PTHR48039:SF5; RNA-BINDING PROTEIN 28; 1.
DR Pfam; PF00076; RRM_1; 6.
DR SMART; SM00360; RRM; 6.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 5.
DR PROSITE; PS50102; RRM; 6.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 2..79
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 296..371
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 404..482
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 589..661
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 728..809
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 811..891
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 83..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..191
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 940 AA; 104798 MW; A6DF7B4312928D5F CRC64;
MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFR SEEEARTALN
HFNRSFIDTS RITVEFCKSF GDPTKPRAWS RHAQKISQSK NPSKDKDSVP TEPKKDDRTR
KVAGELEKLK EDTEFREFLS VHQKRTQTAT WANDVLDAEP SKGKSKAAND YLNFDSDSGQ
ESDEEGAGED PEEEDGRKPR AAVQRELSDM DYLKSKMVKS ESPSSSEEEE SEDEAVSCGD
GSGAEEEAPS PAPAQQDRGR PGAGPEQGVP SGNETPGTAR AEADKAAHQK EPTTPYTVKL
RGAPFNVTEK SVTEFLAPLR PVAIRIVRNA HGNKTGYIFV DFSSEEEVKQ ALKCHREYMG
GRYIEVFREK NVTTAKGPPK NSAKPWQGRT LGENEEEEDL ADSGRLFIRN LPYTSTEEDL
EQLFSKFGPL SELHYPIDSL TKKPKGFAFV TFMFPEHAVR AYAEVDGQVF QGRMLHVLPS
TIKKEASEDT DTPGSSSYKK KKESKDKANS SSSHNWNTLF MGPNAVADAI AQKYSATKSQ
VFDHETKGSV AVRVALGETQ LVQEVRRFLL DNGVSLDSFS QAAAERSKTV ILVKNLPAGT
LAAELQETFG RFGSLGRVLL PEGGVTAIVE FVEPLEARKA FRHLAYSKFH HAPLYLEWAP
VGVFSSSAPQ TKEPKDPPAG PAGEDRAEPE TLPDHETPEG EKPAEGGAEN CPAKVEEEEE
EEESLPGCAL FIKNLNFNTT EETLKEVFSK VGTVRSCSIS KKKNKAGVLL SMGFGFVEYR
KPEQAQKALK QLQPALTSAR KKQVLRKQTT SKILVRNIPF QADSREIREL FSTFGELKTV
RLPKKMTGTG THRGFGFVDF LTKQDAKRAF QALCHSTHLY GRRLVLEWAD SEVSLQTLRR
KTAERFHEPP KKKRSVVLDE ILEQLEDSEN DSEEQTLQLR
//
