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Database: UniProt
Entry: G1LQ14_AILME
LinkDB: G1LQ14_AILME
Original site: G1LQ14_AILME 
ID   G1LQ14_AILME            Unreviewed;       724 AA.
AC   G1LQ14;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=2'-5' oligoadenylate synthase {ECO:0000256|ARBA:ARBA00012577};
DE            EC=2.7.7.84 {ECO:0000256|ARBA:ARBA00012577};
GN   Name=OAS2 {ECO:0000313|Ensembl:ENSAMEP00000009144.2};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009144.2, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000009144.2, ECO:0000313|Proteomes:UP000008912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000009144.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-
CC         adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84;
CC         Evidence={ECO:0000256|ARBA:ARBA00001112};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the 2-5A synthase family.
CC       {ECO:0000256|ARBA:ARBA00009526}.
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DR   AlphaFoldDB; G1LQ14; -.
DR   STRING; 9646.ENSAMEP00000009144; -.
DR   Ensembl; ENSAMET00000009535.2; ENSAMEP00000009144.2; ENSAMEG00000008674.2.
DR   eggNOG; ENOG502S649; Eukaryota.
DR   GeneTree; ENSGT00510000046406; -.
DR   HOGENOM; CLU_026275_0_0_1; -.
DR   InParanoid; G1LQ14; -.
DR   TreeFam; TF329749; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0001730; F:2'-5'-oligoadenylate synthetase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0070106; P:interleukin-27-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:1903487; P:regulation of lactation; IEA:Ensembl.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:Ensembl.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   CDD; cd05400; NT_2-5OAS_ClassI-CCAase; 2.
DR   Gene3D; 1.10.1410.20; 2'-5'-oligoadenylate synthetase 1, domain 2; 2.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 2.
DR   InterPro; IPR018952; 2-5-oligoAdlate_synth_1_dom2/C.
DR   InterPro; IPR006117; 2-5OAS_C_CS.
DR   InterPro; IPR043518; 2-5OAS_N_CS.
DR   InterPro; IPR006116; NT_2-5OAS_ClassI-CCAase.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   PANTHER; PTHR11258:SF3; 2'-5'-OLIGOADENYLATE SYNTHASE 2; 1.
DR   PANTHER; PTHR11258; 2-5 OLIGOADENYLATE SYNTHETASE; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   Pfam; PF10421; OAS1_C; 2.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 2.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 2.
DR   PROSITE; PS00832; 25A_SYNTH_1; 1.
DR   PROSITE; PS00833; 25A_SYNTH_2; 2.
DR   PROSITE; PS50152; 25A_SYNTH_3; 2.
PE   3: Inferred from homology;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT   DOMAIN          154..336
FT                   /note="2'-5'-oligoadenylate synthetase 1"
FT                   /evidence="ECO:0000259|Pfam:PF10421"
FT   DOMAIN          372..437
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          495..681
FT                   /note="2'-5'-oligoadenylate synthetase 1"
FT                   /evidence="ECO:0000259|Pfam:PF10421"
SQ   SEQUENCE   724 AA;  82622 MW;  2E62EFCC2C25ED24 CRC64;
     MGIWASHLYS VPPEKLDELI ENSLRPYGEC QKHIDDTVNA VCAVLQEMEQ IPRTISVVKG
     GSYGRKTVLR GSSDGTIIIF VSDLEQFQDQ KKNQDKILSK IWQCLKDCQL TMKLPARMEV
     QGFHRGLTFQ LSTKWQTIAF EVLPAYNALG LSEKPSPQTY RELRRALDTA KAQPGEFSVC
     FAELRQRFFH NRPRKLRDLI LLVKYWYQQC QEKMKGLPQS AVYALELLTV YAWEQGCRAE
     NFDMAEGLRT VLGLIRQQEQ LCVYWIINYN FENETVRNIL LSQLRSLRPV ILDPADPTNN
     VSKDKACWQL LKQEAQSWLS SLSPNESPGP SWNVLPAPLF TTPGHLLDKF IKDFLQPNKQ
     FLDQIAVAVD FICKFLQKNC FRRSATKVQK IVKGGSTGKG TALKTGSDAD LVVFPDSLKS
     YASQKNERCC IIKEIHKQLV ACQQEKEFAV KFEISKWKAP RVLSFSLRSK VLNESVNFDV
     LPAFNALGQL NSGSPPSPKV YAELIDLYKS SDTEGGEFST CFTELQCNFV VSRPTKLKDL
     IRLVKHWYKQ CERKLKQKGS LPPKYALELL TIYSWEQGSG AENFDTAEGF RTVLELITKY
     QQLCVFWTVN YSFEDETVRN FLLTQIQRTR PVILDPADPT GDVGGGDRWC WHLLAKEATE
     WLSSFCFKDG TGYPVRSWKV PTVQTPGSCG LGMRPIVNEM FSFRSRGILE CNARRDFRSS
     DSCF
//
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