ID G1LR45_AILME Unreviewed; 320 AA.
AC G1LR45;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 {ECO:0000256|ARBA:ARBA00015852};
DE AltName: Full=Multisynthase complex auxiliary component p38 {ECO:0000256|ARBA:ARBA00032155};
DE AltName: Full=Protein JTV-1 {ECO:0000256|ARBA:ARBA00031241};
GN Name=AIMP2 {ECO:0000313|Ensembl:ENSAMEP00000009529.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009529.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000009529.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000009529.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G1LR45; -.
DR STRING; 9646.ENSAMEP00000009529; -.
DR Ensembl; ENSAMET00000009941.2; ENSAMEP00000009529.2; ENSAMEG00000009065.2.
DR eggNOG; ENOG502QUNJ; Eukaryota.
DR GeneTree; ENSGT00390000015826; -.
DR HOGENOM; CLU_076114_0_0_1; -.
DR InParanoid; G1LR45; -.
DR TreeFam; TF326322; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0060510; P:type II pneumocyte differentiation; IEA:Ensembl.
DR CDD; cd03200; GST_C_AIMP2; 1.
DR Gene3D; 1.20.1050.130; -; 1.
DR InterPro; IPR042360; AIMP2.
DR InterPro; IPR031889; AIMP2_LysRS-bd.
DR InterPro; IPR041503; AIMP2_thioredoxin.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004046; GST_C.
DR PANTHER; PTHR13438; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR13438:SF2; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2; 1.
DR Pfam; PF16780; AIMP2_LysRS_bd; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF18569; Thioredoxin_16; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..44
FT /note="AIMP2 lysyl-tRNA synthetase binding"
FT /evidence="ECO:0000259|Pfam:PF16780"
FT DOMAIN 118..208
FT /note="AIMP2 thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18569"
FT DOMAIN 245..308
FT /note="Glutathione S-transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00043"
FT REGION 31..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 35175 MW; 3934812278BF5C31 CRC64;
MPMYQVKPYH GGSASLRVEL PTCMYRLPNV HGRTGSPAPD AGHVQEESDP SLQALESHQD
DILKRLYELK AAVDGLSKMI QTPDADMDVT NIIQAEEPSA FSTSALDLNS VLGKDYGALK
DIVINANPAS PPLSLLVLHR LLCDHYRVLS TVHTHSAVKS VPENLLKCFG EQTKKQPRHE
YQLGFTLIWK NVPKTQMKFS IQTMCPIEGE GNIARFLFSL FGQKQSAVNL TLIDSWVDIA
IFQLKEGSSK EKAAVFRSMN SALGKSPWLV GNELTVADVV LWSVLQQTGG GGGPVPANVQ
KWMQACENLA HFNTALKLLK
//
