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Database: UniProt
Entry: G1LTA3_AILME
LinkDB: G1LTA3_AILME
Original site: G1LTA3_AILME 
ID   G1LTA3_AILME            Unreviewed;      1306 AA.
AC   G1LTA3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   08-NOV-2023, entry version 79.
DE   SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSAMEP00000010299.2};
GN   Name=SOS2 {ECO:0000313|Ensembl:ENSAMEP00000010299.2};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000010299.2, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000010299.2, ECO:0000313|Proteomes:UP000008912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000010299.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   STRING; 9646.ENSAMEP00000010299; -.
DR   Ensembl; ENSAMET00000010748.2; ENSAMEP00000010299.2; ENSAMEG00000009734.2.
DR   eggNOG; KOG3417; Eukaryota.
DR   GeneTree; ENSGT00940000158324; -.
DR   HOGENOM; CLU_002744_0_0_1; -.
DR   InParanoid; G1LTA3; -.
DR   TreeFam; TF317296; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:2000973; P:regulation of pro-B cell differentiation; IEA:Ensembl.
DR   GO; GO:0033081; P:regulation of T cell differentiation in thymus; IEA:Ensembl.
DR   GO; GO:0042129; P:regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR   CDD; cd01261; PH_SOS; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 6.10.250.3060; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT   DOMAIN          169..359
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          412..515
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          566..710
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          749..988
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          989..1033
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1047..1067
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1112..1306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1005..1025
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1122..1136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1144..1160
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1168..1196
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1258..1278
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1306 AA;  149921 MW;  9184821DDD1A7400 CRC64;
     VQEQVHPNLS ANEESLYYIE ELIFQLLNKL CMAQPRTVQD VEERVQKTFP HPIDKWAIAD
     AQSAIEKRKR RNPLLLPVDK IHPSLKEVLG YKVDYHVSLY IVAVLEYISA DILKLAGNYV
     FNIRHYEISQ QDIKVSMCAD KVLMDMFDQD DIGLVSLCED EPRSSGELNY YDLVRTEIAE
     ERQYLRELNM IIKVFREAFL SDRKLFKPSD IDRIFSNISD IHELTVKLLG LIEDTVEMTD
     ESSPHPLAGS CFEDLAEEQA FDPYETLSQD ILSPKFNEHF SKLMARPAVA LHFQSIADGF
     KEAVRYVLPR LMLVPVYHCW HYFELLKQLK ACSEEQEDRE CLNQAITALM NLQGSMDRIY
     KQYSPRRRPG DPVCPFYNRQ LRSKHLAIKK MNEIQKNIDG WEGKDIGQCC NEFIMEGPLT
     RIGAKHERHI FLFDGLMISC KPNHSQSRLP GYSSAEYRLK EKFVMRKIQI CDKEDTCECK
     HAFELVSKDE NSIVFAAKSA EEKNNWMAAL ISLHYRSTLD RMLDSVLLKE ENEQPLRLPS
     PEVYRFVVKD SEENIVFEDN LQSRSGIPII KGGTVVKLIE RLTYHMYADP NFVRTFLTTY
     RSFCKPQELL SLLIERFEIP EPEPTEADKL AVEKGEQPIS ADLKRFRKEY VQPVQLRILN
     VFRHWVEHHF YDFERDLELL ERLESFISSV RGKAMKKWVE SIAKIIKRKK QAQANGISHN
     ITFESPPPPT EWHISRPGQF ETFDLMTLHP IEIARQLTLL ESDLYRKVQP SELVGSVWTK
     EDKEINSPNL LKMIRHTTNL TLWFEKCIVE AENFEERVAI LSRIIEILQV FQDLNNFNGV
     LEIVSAVNSV SVYRLDHTFE ALQERKRRIL DEAVELSQDH FKKYLVKLKS INPPCVPFFG
     IYLTNILKTE EGNNDFLKKK GKDLINFSKR RKVAEITGEI QQYQNQPYCL RIEPEMRRFF
     ENLNPMGSAS EKEFTDYLFN KSLEIEPRNC KQPPRFPRKS TFSLKSPGIR PNTGRHGSTS
     GTLRGHPTPL EREPCKMSFS RIAETDIEST VSAPTSPNTP STPPVSASSD LSVFLDVDLS
     SSCGSNSIFA PVLLPHSKSF FSSCGSLHKL SEEPLIPPPL PPRKKFEDDA SNSKGNTKSD
     DDPPAIPPRQ PPPPKVKPRA PAPTGAFDGP LHSPPPPPPR DPLPDTPPPV PLRPPEHFLN
     CPFNLQPPPL GHLHRDPDWF RDVSTCPNSP NTPPSTPSPR VPRRCYVLSS SHNHLAHPQA
     PPVPPRQSSS PHLPNLPKLP PKTYKRELSH PPSFRLPVLE NAETPQ
//
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