ID G1LTA3_AILME Unreviewed; 1306 AA.
AC G1LTA3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 08-NOV-2023, entry version 79.
DE SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSAMEP00000010299.2};
GN Name=SOS2 {ECO:0000313|Ensembl:ENSAMEP00000010299.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000010299.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000010299.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000010299.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR STRING; 9646.ENSAMEP00000010299; -.
DR Ensembl; ENSAMET00000010748.2; ENSAMEP00000010299.2; ENSAMEG00000009734.2.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000158324; -.
DR HOGENOM; CLU_002744_0_0_1; -.
DR InParanoid; G1LTA3; -.
DR TreeFam; TF317296; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:2000973; P:regulation of pro-B cell differentiation; IEA:Ensembl.
DR GO; GO:0033081; P:regulation of T cell differentiation in thymus; IEA:Ensembl.
DR GO; GO:0042129; P:regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 169..359
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 412..515
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 566..710
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 749..988
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 989..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1160
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1196
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1278
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1306 AA; 149921 MW; 9184821DDD1A7400 CRC64;
VQEQVHPNLS ANEESLYYIE ELIFQLLNKL CMAQPRTVQD VEERVQKTFP HPIDKWAIAD
AQSAIEKRKR RNPLLLPVDK IHPSLKEVLG YKVDYHVSLY IVAVLEYISA DILKLAGNYV
FNIRHYEISQ QDIKVSMCAD KVLMDMFDQD DIGLVSLCED EPRSSGELNY YDLVRTEIAE
ERQYLRELNM IIKVFREAFL SDRKLFKPSD IDRIFSNISD IHELTVKLLG LIEDTVEMTD
ESSPHPLAGS CFEDLAEEQA FDPYETLSQD ILSPKFNEHF SKLMARPAVA LHFQSIADGF
KEAVRYVLPR LMLVPVYHCW HYFELLKQLK ACSEEQEDRE CLNQAITALM NLQGSMDRIY
KQYSPRRRPG DPVCPFYNRQ LRSKHLAIKK MNEIQKNIDG WEGKDIGQCC NEFIMEGPLT
RIGAKHERHI FLFDGLMISC KPNHSQSRLP GYSSAEYRLK EKFVMRKIQI CDKEDTCECK
HAFELVSKDE NSIVFAAKSA EEKNNWMAAL ISLHYRSTLD RMLDSVLLKE ENEQPLRLPS
PEVYRFVVKD SEENIVFEDN LQSRSGIPII KGGTVVKLIE RLTYHMYADP NFVRTFLTTY
RSFCKPQELL SLLIERFEIP EPEPTEADKL AVEKGEQPIS ADLKRFRKEY VQPVQLRILN
VFRHWVEHHF YDFERDLELL ERLESFISSV RGKAMKKWVE SIAKIIKRKK QAQANGISHN
ITFESPPPPT EWHISRPGQF ETFDLMTLHP IEIARQLTLL ESDLYRKVQP SELVGSVWTK
EDKEINSPNL LKMIRHTTNL TLWFEKCIVE AENFEERVAI LSRIIEILQV FQDLNNFNGV
LEIVSAVNSV SVYRLDHTFE ALQERKRRIL DEAVELSQDH FKKYLVKLKS INPPCVPFFG
IYLTNILKTE EGNNDFLKKK GKDLINFSKR RKVAEITGEI QQYQNQPYCL RIEPEMRRFF
ENLNPMGSAS EKEFTDYLFN KSLEIEPRNC KQPPRFPRKS TFSLKSPGIR PNTGRHGSTS
GTLRGHPTPL EREPCKMSFS RIAETDIEST VSAPTSPNTP STPPVSASSD LSVFLDVDLS
SSCGSNSIFA PVLLPHSKSF FSSCGSLHKL SEEPLIPPPL PPRKKFEDDA SNSKGNTKSD
DDPPAIPPRQ PPPPKVKPRA PAPTGAFDGP LHSPPPPPPR DPLPDTPPPV PLRPPEHFLN
CPFNLQPPPL GHLHRDPDWF RDVSTCPNSP NTPPSTPSPR VPRRCYVLSS SHNHLAHPQA
PPVPPRQSSS PHLPNLPKLP PKTYKRELSH PPSFRLPVLE NAETPQ
//