ID G1LW71_AILME Unreviewed; 960 AA.
AC G1LW71;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5D {ECO:0000313|Ensembl:ENSAMEP00000011322.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011322.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000011322.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011322.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1LW71; -.
DR STRING; 9646.ENSAMEP00000011322; -.
DR Ensembl; ENSAMET00000011804.2; ENSAMEP00000011322.2; ENSAMEG00000010697.2.
DR eggNOG; KOG1480; Eukaryota.
DR GeneTree; ENSGT00950000182815; -.
DR InParanoid; G1LW71; -.
DR TreeFam; TF316767; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; IEA:Ensembl.
DR CDD; cd08801; Death_UNC5D; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR042058; UNC5D_Death.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 33..960
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5030003147"
FT TRANSMEM 387..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 168..246
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 549..689
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 960 AA; 106562 MW; E9C0550CFC9CAA52 CRC64;
MGRAAAAGGG AGGARVWLPW LGLCFWAAGA AAAAARGTDN GEALPESIPS APGTLPHFIE
EPDDAYIIKS NPIALRCKAR PAMQIFFKCN GEWVHQNEHV SEESLDESSG LKVREVFINV
TRQQVEDFHG PEDYWCQCVA WSHLGTSKSR KASVRIAYLR KNFEQDPQGR EVPIEGMIVL
HCRPPEGVPA AEVEWLKNEE PIDSEQDENI DTRADHNLII RQARLSDSGN YTCMAANIVA
KRRSLSATVV VYVNGGWSSW TEWSACNVRC GRGWQKRSRT CTNPAPLNGG AFCEGMSVQK
ITCTSLCPVD GSWEVWSEWS VCSPECEHLR MRECTAPPPR NGGKFCEGLS QESENCTDGL
CILDKKPLHE IKPQRWSRRG IENASDIALY SGLGAAVVAV AVLVIGVTLY RRSQSDYGVD
VIDSSALTGG FQTFNFKTVR QGNSLLLNSS MQPDLTVSRT YSGPICLQDP LDKELMTESS
LFNPLSDIKV KVQSSFMVSL GVSERAEYHG KNHSGTFPHG NNRSFSTIHP RNKTPYIQNL
SSLPTRTELR TTGVFGHLGG RLVMPNTGVS LLIPHGAIPE ENSWEIYMSI NQGEPSLQSD
GSEVLLSPEV TCGPPDMTVT TPFALTIPHC ADVSSEHWNI HLKKRTQQGK WEEVMSVEDE
STSCYCLLDP FACHVLLDSF GTYALTGEPV TDCAVKQLKV AVFGCMSCNS LDYNLRVYCV
DNTPWAFQEV VSDERHQGGQ LLEEPKLLHF KGNTFSLQIS VLDIPPFLWR IKPFTACQEV
PFARVWCSNR QPLHCAFSLE RYTPTTTQLS CKICIRQLKG HEQILQVQTS ILESERETIT
FFAQEDSTFP AQTGPKAFKI PYSIRQRICA TFDTPNAKGK DWQMLAQKNS INRNLSYFAT
QSSPSAVILN LWEARHQHDG NLDSLACALE EIGRTHTKLS NITESQLDEA DFNYSRQNGL
//
