ID G1LYK1_AILME Unreviewed; 1679 AA.
AC G1LYK1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=CLTC {ECO:0000313|Ensembl:ENSAMEP00000012157.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000012157.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000012157.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000012157.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR STRING; 9646.ENSAMEP00000012157; -.
DR Ensembl; ENSAMET00000012675.2; ENSAMEP00000012157.2; ENSAMEG00000011481.2.
DR eggNOG; KOG0985; Eukaryota.
DR GeneTree; ENSGT00950000183166; -.
DR HOGENOM; CLU_002136_0_0_1; -.
DR OrthoDB; 5474327at2759; -.
DR TreeFam; TF300059; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF7; CLATHRIN HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 335..358
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1679 AA; 192060 MW; F501937DD8B0B702 CRC64;
MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN
PIRRPISADS AIMNPASKVI ALKGIKDSGK TLQIFNIEMK SKMKAHTMTD DVTFWKWISL
NTVALVTDNA VYHWSMEGES QPVKMFDRHS SLAGCQIINY RTDAKQKWLL LTGISAQQNR
VVGAMQLYSV DRKVSQPIEG HAASFAQFKM EGNAEESTLF CFAVRGQAGG KLHIIEVGTP
PTGNQPFPKK AVDVFFPPEA QNDFPVAMQI SEKHDVVFLI TKYGYIHLYD LETGTCIYMN
RISGETIFVT APHEATAGII GVNRKGQVLS VCVEEENIIP YITNVLQNPD LALRMAVRNN
LAGAEELFAR KFNALFAQGN YSEAAKVAAN APKGILRTPD TIRRFQSVPA QPGQTSPLLQ
YFGILLDQGQ LNKYESLELC RPVLQQGRKQ LLEKWLKEDK LECSEELGDL VKSVDPTLAL
SVYLRANVPN KVIQCFAETG QVQKIVLYAK KVGYTPDWIF LLRNVMRISP DQGQQFAQML
VQDEEPLADI TQIVDVFMEY NLIQQCTAFL LDALKNNRPS EGPLQTRLLE MNLMHAPQVA
DAILGNQMFT HYDRAHIAQL CEKAGLLQRA LEHFTDLYDI KRAVVHTHLL NPEWLVNYFG
SLSVEDSLEC LRAMLSANIR QNLQICVQVA SKYHEQLSTQ SLIELFESFK SFEGLFYFLG
SIVNFSQDPD VHFKYIQAAC KTGQIKEVER ICRESNCYDP ERVKNFLKEA KLTDQLPLII
VCDRFDFVHD LVLYLYRNNL QKYIEIYVQK VNPSRLPVVI GGLLDVDCSE DVIKNLILVV
RGQFSTDELV AEVEKRNRLK LLLPWLEARI HEGCEEPATH NALAKIYIDS NNNPERFLRE
NPYYDSRVVG KYCEKRDPHL ACVAYERGQC DLELINVCNE NSLFKSLSRY LVRRKDPELW
GSVLLESNPY RRPLIDQVVQ TALSETQDPE EVSVTVKAFM TADLPNELIE LLEKIVLDNS
VFSEHRNLQN LLILTAIKAD RTRVMEYINR LDNYDAPDIA NIAICNELFE EAFAIFRKFD
VNTSAVQVLI EHIGNLDRAY EFAERCNEPA VWSQLAKAQL QKGMVKEAID SYIKADDPSS
YMEVVQAANT SGNWEELVKY LQMARKKARE SYVETELIFA LAKTNRLAEL EEFINGPNNA
HIQQVGDRCY DEKMYDAAKL LYNNVSNFGR LASTLVHLGE YQAAVDGARK ANSTRTWKEV
CFACVDGKEF RLAQMCGLHI VVHADELEEL INYYQDRGYF EELITMLEAA LGLERAHMGM
FTELAILYSK FKPQKMREHL ELFWSRVNIP KVLRAAEQAH LWAELVFLYD KYEEYDNAII
TMMNHPTDAW KEGQFKDIIT KVANVELYYR AIQFYLEFKP LLLNDLLMVL SPRLDHTRAV
NYFSKVKQLP LVKPYLRSVQ NHNNKSVNES LNNLFITEED YQALRTSIDA YDNFDNISLA
QRLEKHELIE FRRIAAYLFK GNNRWKQSVE LCKKDSLYKD AMQYASESKD TELAEELLQW
FLQEEKRECF GACLFTCYDL LRPDVVLETA WRHNIMDFAM PYFIQVMKEY LTKVDKLDAS
ESLRKEEEQA TETQPIVYGQ PQLMLTAGPS VAVPPQAPFG YGYTAPPYGQ PQPGFGYSM
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