ID G1M8D3_AILME Unreviewed; 1162 AA.
AC G1M8D3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Class II major histocompatibility complex transactivator {ECO:0000313|Ensembl:ENSAMEP00000015603.2};
GN Name=CIITA {ECO:0000313|Ensembl:ENSAMEP00000015603.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000015603.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000015603.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000015603.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1M8D3; -.
DR STRING; 9646.ENSAMEP00000015603; -.
DR Ensembl; ENSAMET00000016253.2; ENSAMEP00000015603.2; ENSAMEG00000014772.2.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000161578; -.
DR HOGENOM; CLU_010691_1_0_1; -.
DR TreeFam; TF352118; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR008095; MHC_II_transact.
DR InterPro; IPR007111; NACHT_NTPase.
DR PANTHER; PTHR47189; MHC CLASS II TRANSACTIVATOR; 1.
DR PANTHER; PTHR47189:SF1; MHC CLASS II TRANSACTIVATOR; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR PRINTS; PR01719; MHCIIACTVATR.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 442..756
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 343..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 126602 MW; 55763715C35D36AC CRC64;
MNHFQTILPR VRMLLSSYRP GQVQALLDHM LEKELLSQEY HGALLREPDG EALARKISLT
LLEKGDPDLA LLRWAWSGWQ APVAERDPDS KDHSGSGQCA AMELGPLEGG YLELLNSSAD
PLQLYHLYDQ TDLAREEIEL CSEADVDTIN CDQFSRLLCD MEGDEETREA YANIAELDQY
VFQDSQLDGL GKDIFIEHIG LEEMISESVE VEEAGQKSQK RPFPEELPVD LKHRKLAEAL
AVPAVTGTFL VGSASDSSAL PCLSPPAVFN KEPASSQSWL EEPVLMPVPP SSSLLSCLSL
SAGRIQIVPS LPSLPQGLWQ ISGPGTGVSG MVIYQGEMPQ ASQVLPSSGP AMQSLPKSPE
RPGSTSPFAP SAADLPGMPE PALTSRANMT EDQMSPTQCL TAHEVSSKPP KWPETVEQFC
SSLRDKYQAE PADPEGILVE VELVRARLER NSGKSQEREL ATPDWAERQL VRGGLAEVLL
AAGDRRRPRE TQDTYRLQDL LFCLGPQPQP VDEEVFGHIL RRPDRVLLIL DAFEGLEGQD
GLLHSAGGPV STEPHSLRGL LAGLFQRKLL RGCTLLLTAR PRGRLAHSLS KADILFEVTG
FSAEQAETYV TRYLERAGAT EHREQALALL RGQPFLLSHS HSPTVCRAVC QLSEALLELG
GEAELPSTLT GLYVGLLGPA ARDSPPGALA GLARLAWELG RRHRGTLQDS QFPSAEVRAW
AVARGLVQPV PGAPDAELAF SSFLLQCFLG AMWLALSTEI KDKELPQYLA LTPRKKRPYD
NWLEGVPRFL AGLLFQPHAD CLGALAGPAL AALGARKQKV LSRYLKRLQP GTLRAGRLLE
LLHCAHEASD AGLWQHVVQG LPARLSFLGT RLTPPNTYVL CSALAAAGRD FSLDLRSTGI
DPSGLGSLVG LGCVTHFRAS LSDTVGLWES LQQRGETKLL RAVEEKFTIE PFKAKSPKDV
DDLGNLVQIQ RTRSSSEDAA EELPAVRDLK KLEFALGSVL GPQAFPKLVR ILEAFSSLQH
LDLDSLSENK IGDKGVEQLS ATFPRLKALE TLNLSQNSIT DVGACKLAEA LPSLAASLLR
LSLYNNSICD VGAESLAHVL PDMVSLRVLD VQYNKFTAAG AQQLAASLRK CPHVETLAMW
TPTIPFGVHE HLQQLDSRIS LR
//
