ID G1MAN3_AILME Unreviewed; 698 AA.
AC G1MAN3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=mRNA export factor GLE1 {ECO:0000256|ARBA:ARBA00026227};
DE AltName: Full=GLE1 RNA export mediator {ECO:0000256|ARBA:ARBA00030897};
DE AltName: Full=GLE1-like protein {ECO:0000256|ARBA:ARBA00031503};
DE AltName: Full=Nucleoporin GLE1 {ECO:0000256|ARBA:ARBA00029983};
GN Name=GLE1 {ECO:0000313|Ensembl:ENSAMEP00000016407.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016407.1, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000016407.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000016407.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC from the nucleus into the cytoplasm. May be involved in the terminal
CC step of the mRNA transport through the nuclear pore complex (NPC).
CC {ECO:0000256|ARBA:ARBA00024680}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the GLE1 family.
CC {ECO:0000256|ARBA:ARBA00011056}.
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DR RefSeq; XP_002915233.1; XM_002915187.3.
DR AlphaFoldDB; G1MAN3; -.
DR STRING; 9646.ENSAMEP00000016407; -.
DR Ensembl; ENSAMET00000017086.2; ENSAMEP00000016407.1; ENSAMEG00000015537.2.
DR GeneID; 100482913; -.
DR KEGG; aml:100482913; -.
DR CTD; 2733; -.
DR eggNOG; KOG2412; Eukaryota.
DR GeneTree; ENSGT00390000012903; -.
DR HOGENOM; CLU_024662_1_0_1; -.
DR InParanoid; G1MAN3; -.
DR OMA; TFWKLLP; -.
DR OrthoDB; 317142at2759; -.
DR TreeFam; TF324158; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.510; GLE1-like; 1.
DR InterPro; IPR012476; GLE1.
DR InterPro; IPR038506; GLE1-like_sf.
DR PANTHER; PTHR12960; GLE-1-RELATED; 1.
DR PANTHER; PTHR12960:SF0; MRNA EXPORT FACTOR GLE1; 1.
DR Pfam; PF07817; GLE1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REGION 60..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 206..241
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 60..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 79504 MW; F53D99A1E8F5EA80 CRC64;
MPSEGRCWET LQALRSSDKG RLCYHRDWLL RGEDVLEECM SLPKLSSYSG WVVDHVLSHT
QENPPSSETS ASSRATSALD QPSCVPRSPV RTPASSSSSS ATPDGAEGKH ESQHTESVVL
QSSRGIKVEG CIRMYELVHR MRGTEGLRQW QEEQERKVRA LSEMASEQLK RFDERKELKH
HKEFQDLQEV MEKSSREALG HQEKLKAEHR HRAKILNLKL REAEQQRLKQ AEQERLRKEE
GQVRLRSLYA LQGEVLHLNQ QLDASEQPRD VPKPDLSAFR TRGNQLCGLV SGIVRATSEN
GFPTAEDQAV AEKALQEMRD LLTSLQQEIA RACEDKRRQD EEAAQEKQQE SKMQQGPEVP
RETPAPSQGP GGKQNEDLQV KVQDSTMQWY QQLQDASSQC VLAFEELTNS KDSQAKKIKM
DLQKAATIPV SQISTIAGSK LKEIFDKIHS LLSGKPVQCG GHSVSVTLNP QGLDFVQYKL
AEKFVKQGEE EVASHHEAAF PIAVVASGIW ELHPRVGDLI LAHLHRKCPY SVPFYPAFKE
GMALEDYQRM LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGSR QEIHPHGLNH
GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMILLIKE EYFPRIEAVT
SSGQMGSFIR LKQFLEKCLQ RKEIPVPKGF LTSSFWRS
//
