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Database: UniProt
Entry: G1MB75_AILME
LinkDB: G1MB75_AILME
Original site: G1MB75_AILME 
ID   G1MB75_AILME            Unreviewed;      2029 AA.
AC   G1MB75;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 6 {ECO:0000313|Ensembl:ENSAMEP00000016603};
GN   Name=TRPM6 {ECO:0000313|Ensembl:ENSAMEP00000016603};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016603, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000016603}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000016603}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000016603}.
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DR   EMBL; ACTA01091903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01099903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01107903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000016603; -.
DR   Ensembl; ENSAMET00000017288; ENSAMEP00000016603; ENSAMEG00000015683.
DR   eggNOG; ENOG410INBW; Eukaryota.
DR   eggNOG; ENOG410ZSH9; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; G1MB75; -.
DR   OMA; NERMAMK; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; IEA:Ensembl.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0030001; P:metal ion transport; IEA:Ensembl.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029597; TRPM6.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF15; PTHR13800:SF15; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    844    863       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    980   1000       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1053   1076       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1097   1117       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1756   1987       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
FT   COILED      654    681       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2029 AA;  232448 MW;  AD4B6FEBDA8615E7 CRC64;
     ASEYRCPPRI QSQKSWIEGV FNKRECNKII PSSKDPHRCT AGCQVCQNLI RCYCGRLIGD
     HHGIDYSWTI SAANGNENEP WSVEKHTTKS PTDTFGTINF QDGEHTHHSK YIRISYDTKL
     DHLLHLMLKE WKMELPKLVI SVHGGIQNFK MPSKLKEIFS QGLVKAAETT GAWIITEGIN
     TGVSKHVGDA LRAHSFQSLR KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LGNPLSKLTT
     LNSMHSHFIL SDDGTVGKYG NEMKLRRSLE KYLSLQKIHS RSRQGVPVVG LVVEGGPNVI
     LAVWETVRDK DPVVVCDGTG RAADLLAFTH KHLDEGALRP QVKEEIICMI QNAFNFSLKQ
     SKHLFQILME CMVHRDSITI FDADSEESQD LDLAILTALL KGTNLTASEQ LNLAMAWDRM
     DIAKKHILIY GQHWKAGALE QAMLDALVMD RVDFVKLLIE YGVNLHRFLT IPRLEELYNT
     KQGPTNMLLH HLVRDVKQHA LLSGYRITLI DIGLVIEYLI GGAYRSSYTR KSFRALYNNL
     YRKHKPPLHR RRPSGNRKES AESTLHSQFI RTAQPYKFKE KSVVLHKSRK KSKEEQSISD
     DPESTGFIYP YNDLLVWAVL MKRQKMAMFF WQHGEEATVK AVIAYKLYRA MAHEAKESNM
     MDDASEELKN YSKQFGQLAL DVLEKAFKQN ERMAMKLLTY ELKNWSNSTC LKLAATGRLR
     PFVSHTCTQM LLTDMWTGRL KMRKNSWLKI IVSILFPPTI LSLEFKSRAE MSHVPQPQDF
     QFAWYYGDQN PSAKESAYMK DCDLERGPDE KLDENQHFDL KSDPQSLPWT RKIYEFYSAP
     IVKFWFYTMA YLAFLMLFTY TVLVEMQPQP SVQEWLVIIY IFTNAIEKVR EVCISEPGKF
     TQKVKVWISE YWNVIETVAI GLFSVGFGLR WGDPPLHTAG RLIYCIDIIF WFSRLLDFFA
     VNQHVGPYVT MIAKMTANMF YIVTLMAIVL LSFGVARKAI LSPKQLPSWS LARDIVFEPY
     WMIYGEVYAA DIDVCASSPS CPPGSFLTPF LQAVYLFVQY IIMVNLLIAF FNNVYVDMKS
     ISNKLWKYNR YRYIMTYHKK PWLPPPFILL SHVGLFLRRL CHHQAPNDQE EGDVGLKLYL
     SEEDLKRLHD FEEQCVEIYF HEKMESLNYS CEERIRVTSE RVTEMYFQMK EMNEKVSFIK
     DSLLSLDSQV GHLQDLSALT VDTLKFLSAV DTLQEDEALL ANRKHSTCRK LPHSWSNIIC
     AGVPGSMEIS GEKKYQYYSM PPSLLRSLAR GQHTLRVQRE PLLEITDSQR EVSNVIDEQE
     KQEIETTIVA SGVSINRQSQ RKYGQFLLVP SYLKQVPFSA ETDFPLFRPS VEAGTDVLAV
     KQVTQSEVPV RLTWQSPALS AQGSVAEPEA QYESVSQIPA RQDKGGEQVL PTFICTSPPM
     KMTSLPSQGE STGTGGGYVN WAFSEGDETG VFSIKKKWQT CLASTCNSDS KESGQSQRQI
     RARSLSENSS SLAHSSDCSE VGPWLQPNTS CWINPFRRDR PFTRSHSLRF HKENKLKISK
     IKNLSRSSEI GQSAWIKTKM LIKDKRSSKK KKKTQGLQVP VIKVDTCSQN DQLESEPGEN
     NISEEEAYSK NWLTVSKFSQ QDLEPSIYQK MKTKEMEQHA IQVSDYLKQS QEDLSKNSLW
     NSRSTTLNRN SLLRSSNGVD KISASLKSPP EPCHHYSAIE RNNLMRLSQT IPFTPIQLFA
     GEEVTVYRLE ESSPLNLDKS MSSWSQRGRA AMIQVLSREE MDGGLRKAMR VISTWSEDDV
     LRPGQVFIVK SFLPEVVKSW HKIFRESTVL HLCLREIQQQ RAAQKLIYTF NHVKPQTIPY
     TPRFLEVFLI YCHSVNQWLT IEKYMTGEFR KYNNNNGDEI APSNTLEELM LAFSHWTYEY
     TRGELLVLDL QGGVGENLTD PSVIKPEDKR SRGMVFGPAN LGEDAIRNFI AKHRCNSCCR
     KLKLPDLKRN DYSPGRINST FGLDVKIKPA EGPLARERGR NSPEDLTRL
//
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