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Database: UniProt
Entry: G1MB90_AILME
LinkDB: G1MB90_AILME
Original site: G1MB90_AILME 
ID   G1MB90_AILME            Unreviewed;      4858 AA.
AC   G1MB90;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   22-NOV-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSAMEP00000016618};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSAMEP00000016618};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016618, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000016618}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000016618}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000016618}.
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DR   EMBL; ACTA01089771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01097771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01105771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01113771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01121771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01129771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01137771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000016618; -.
DR   Ensembl; ENSAMET00000017304; ENSAMEP00000016618; ENSAMEG00000015734.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1MB90; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 4.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4175   4199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4399   4419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4464   4486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4598   4616       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4659   4680       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4739   4762       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       87    142       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      149    194       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      202    256       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      262    320       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      330    387       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      572    783       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      999   1195       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1241   1453       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3906   3941       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4858 AA;  550672 MW;  B229F9E8C2AE27B4 CRC64;
     FSRQEDEVVL QCIANIHKEQ RKFCLAAEGL GNRLCFLEPT SEAKYVPPDL CVCNFVLEQS
     LSVRALQEML ANTGENGGEG AAQGGGHRTL LYGHAILLRH SFSGMYLTCL TTSRSQTDKL
     AFDVGLREHA TGEACWWTIH PASKQRSEGE KVRIGDDLIL VSVSSERYLH LSVSNGNIQV
     DASFMQTLWN VHPTCSGSSI EEGYLLGGHV VRLFHGHDEC LTIPSTDQND AQHRRIFYET
     GGAGTRARSL WRVEPLRISW SGSNIRWGQA FRLRHLTTGH YLALTEDQGL ILQDRAKSDT
     KSTAFSFRAS KEIKEKLDSS HKRDIEGMGV PEIKYGDSVC FVQHVASGLW VTYKAQDAKT
     SRLGPLKRKV ILHQEGHMDD GLTLQRCQRE ESQAARIIRN TTALFSQFVS GNNRTAAPVT
     LPIEEVLQTL QDLIAYFQPP EEEMRHEDKQ NMVRSLKNRQ NLFKEEGMLA LVLNCIDRLN
     IYNSVAHFAG IAREESGMAW KETLNLLYKL LAALIRGNRN NCAQFSNNLD WLISKLDRLE
     SSSGILEVLH CILIESPEAL NLIAEGHIKS IISLLDKHGR NHKVLDVLCS LCLCNGVAVR
     ANQNLICDNL LPRRNLLLQT RLINDVTSIR PNIFLGVAEG SAQYKKWYFE LIIDQVDPFL
     TAEPTHLRVG WASSSGYAPY PGGGEGWGGN GVGDDLYSYG FDGLHLWSGR IPRAVASINQ
     HLLRSDDVVS CCLDLGVPSI SFRINGQPVQ GMFENFNTDG LFFPVVSFSA GVKVRFLMGG
     RHGEFKFLPP SGYAPCYEAL LPKEKMRLEP VKEYKRDAEG VRDLLGTTQS LSQASFIPCP
     IDTSQVVLPP HLEKIRDRLA ENIHELWGMN KIELGWTFGK IRDDNKRQHP CLVEFSKLPE
     TEKNYNLQMS TETLKTLLAL GCRIAHVNPA AEEELKKVKL PKNYTMSNGY KPAPLDLSDV
     KLLPPQEILV DKLAENAHNV WAKDRIKQGW TYGIQQDLKN KRNPRLVPYA LLDERTKKSN
     RDSLREAVRT FVGYGYNIEL SDQELADPAV EKVSIDKIRF FRVERSYAVR SGKWYFEFEV
     VTGGDMRVGW ARPGCRPDIE LGADDQAFVF EGSRGQRWHQ GSGYFGRTWQ PGDVVGCMIN
     LADASMIFTL NGELLITNKG SELAFADYEI ENGFVPICSL GLSQIGRMNL GMDASTFKFY
     TMCGLQEGFE PFAVNMNRDV AMWFSKRLPT FVNVPRDHPH IEVVRIDGTM DSPPCLKVTH
     KTFGTQNSNA GMIYCRLSMP VECHSSFSHS PCLDSDAFQK RKQMQEILSH TTTQCYYAIR
     IFAGQDPSCV WVGWVTPDYH LHSEKFDLNK NCTVTVTLGD ERGRVHESVK RSNCYMVWGG
     DIVATSQRSS RSNVDLEIGC LVDLAMGMLS FSANGRELGT CYQVEPNTKV FPAVFLQPTS
     TSLFQFELGK LKNAMPLSAA IFKSEEKNPV PQCPPRLDVQ TIQPVLWSRM PSSFLKVETE
     RVSERHGWVV QCLEPLQMMA LHIPEENRCV DVLELCEQED LMQFHYHTLR LYSAVCALGN
     SRVAYALCGH VDLSQLFYAI DNQYLPGLLR SGFYDLLISV HLASAKERKL LMKNEYIIPI
     TSSTRKIRLY PDETKRHGLP GVGPRTCLKP GFRFSTPCFV VTGEEHQKQS PEIPLEILKT
     KALSMLTEAV QHSGAHIRDP VGGSVEFQFV PVLKLIGTLL VMGVFDDDDV RQILLLIDPS
     VFGEHSAETE DGAEKKEVTQ VGEKAVEAGR KASKEAPVKG LLQTRLPESV KLQMCELLSY
     LCDCELQHRV EAIVAFGDIY VSKLQANQKF RYNELMQALN MSAALTARKT REFRSPPQEQ
     INMLLNFQLG ENCPCPEEIR EELYDFHEDL LIHCGVPLEE EEEEEEDTSW TGKLRALVYK
     IKGPPKPETE QPTEEEERSP TTLKELISQT MIRWAQEDQI QDAELVRMMF SVLRRQYDSI
     GELLQALRKT YTISQASVSD TVSLLAALGQ IRCLLSVRMG KEEELLMING LGDIMNNKVF
     YQHPNLMRVL GMHETVMEVM VNVLGTEKSQ IAFPKMVASC CRFLCYFCRI SRQNQKAMFE
     HLSYLLENSS VGLASPSMRG STPLDVAASS VMDNNELALG LEEPDLEKVV TYLAGCGLQS
     CPMLLAKGYP DVGWNPIEGE RYLSFLRFAV FVNSESVEEN ASVVVKLLIR RPECFGPALR
     GEGGNGLLAA MQGAIKISEN PALDLPSQGY KREVSTEDSE DEEIVHMGNA IMSFYSALID
     LLGRCAPEMH LIQTGKGEAI RIRSILRSLV PTEDLVGIIS IPLKLPSLNK DGSVCEPDMA
     ANFCPDHKAP MVLFLDRVYG IKDQTFLLHL LEVGFLPDLR ASASLDTVSL STTEAALALN
     RYLCSAVLPL LTRCAPLFAG TEHYTSLIDS TLQTIYRLSK GRSLTKAQRD TIEECLLAIC
     NHLRPSMLQQ LLRRLVFDVP QLNEYCKMPL KLLTNHYEQC WKYYCLPSGW GSYGLAVEEE
     LHLTEKLFWG IFDSLSRKKY DPDLFRMALP CLSAIVGALP PDYLDTRISA TLEKQISVDA
     DGNFDPKPIN TMNFSLPEKW EYIVTKYAEH SHDKWACDKS QNGWKYGISL DENVKTHPLI
     RPFKTLTEKE KEIYRWPARE SLKTMLAVGW SVERTKEGEA LVQQRENEKL RSVSQASQGN
     SYSPAPLDLS NVVLSRELQG MVEVVAENYH NIWAKKKKLE LESKGGGSHP LLVPYDTLTA
     KEKFRDREKA QDLFKFLQVN GIVVSRGMKD MELDASSMEK RFAYKFLKKI LKYVDSAQEF
     IAHLEAIVSS GKTEKSPHDQ EIKFFAKVLL PLVDQYFTNH RLYFLSSPLK PLSSSGYASH
     KEKEMVASLF CKLAALVRHR ISLFGSDSTA MVSCLHILAQ TLDTRTVMKS GSELVKAGLR
     AFFENAAEDL EKTSENLKLG KFTHSRTQIK GVSQNINYTT AALLPILTSI FEHVAQHQFG
     VDLLLGDVQL SCYHILCSLY SLGTGKNIYV ERQRPALGEC LASLAAAIPV AFLEPTLNHY
     NPLSVFNTKT PRERSILGMP DTVEEMCPDI PQLEGLMKEI SDLAESGARY TEMPHVIEVI
     LPMLCNYLSY WWERGPEHLP PGTGPWCTKV TSEHLSVILG NILKIINNNL GIDEASWMKR
     IAVYAQPIIS KARPDLLKSH FIPTLEKLKK KAVKTVQEEE QLKADTRGDT QEAELLILDE
     FAVLCRDLYA FYPMLIRYVD NNRSNWLKSP GADSDQLFRM VAEVFILWCK SHNFKREEQN
     FVIQNEINNL AFLTGDSKSK MSKVSALKSG GQDQERRKTK RRGDLYSIQT SLIVATLKKM
     LPIGLNMCTP GDQELISLAK ARYGSRDTDE EVKEHLRNNL HLQEKSDDPA VKWQLNLYKD
     VLKSEEPFNP EKTVERVQRI SAAVFHLEQV EQPLRSKKAV WHKLLSKQRK RAVVACFRMA
     PLYNLPRHRS INLFLHGYQR FWIETEEYSF EEKLVQDLAK SPKVEEEEEE EETEKQPDPL
     HQIILHFSRN ALTERSKLED DPLYTSYSSM MAKSCQSGED EEEEEDKEKT FEEKEMEKQK
     TLYQQARLHE RGAAEMVLQM ISASKGEMSP MVVETLKLGI AILNGGNAGV QQKMLDYLKE
     KKDAGFFQSL SGLMQSCSVL DLNAFERQNK AEGLGMVTEE GTLIVRERGE KVLQNDEFTR
     DLFRFLQLLC EGHNSDFQNF LRTQMGNTTT VNVIISTVDY LLRLQESISD FYWYYSGKDI
     IDESGQHNFS KALAVTKQIF HSLTEYIQGP CIGNQQSLAH SRLWDAVVGF LHVFANMQMK
     LSQDSSQIEL LKELLDLLQD MVVMLLSLLE GNVVNGTIGK QMVDTLVESS TNVEMILKFF
     DMFLKLKDLT SSDTFKVYDP DGKGIISKKE FQKAMEGQKQ YTQSETDFLL SCAEADENDM
     FNYIDFVDRF HEPAKDIGFN VAVLLTNLSE HMPNDSRLKC LLDPAESVLN YFEPYLGRIE
     IMGGAKKIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEQEKME LFVNFCEDTI
     FEMQLASQIS ESDSADRPDD EEEGGEDSSY LLEIEGGEQD DKSFESASAF AMACASVKRN
     VANFLRKATL RNLRKQCRKV KKLTVKELVK EFFSFFWMLF VGLFRLFFTI LGGIFQILWN
     TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG IHEDTLDAER VEVTEPGVPP ELIHFVKGEK
     GDAEAMSELF GFRPKKEGGL KHRPEGGLGD LSEIIGKDEP PTLESTVRKK RRAQAAEMKA
     AHEAEGKVEP EKTDLEDGEK EVMAKEEEQA KALWTDVTKK KKRRRGQKVE KPEAFMANFF
     KGLEIYQTKL LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLEEET EDVANLWNSF
     NDEEEEEAMV FFVLQESTGY MAPMLRALAV IHTVISLVCV VGYYCLKVPL VVFKREKEIA
     RKLEFDGLYI TEQPSEDDIK GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA
     ELLGLDRNAL DFSPVEESKA EASSLVSWLS SIDMKYHIWK LGVVFTDNSF LYLAWYTSMS
     VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF
     RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT
     FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VREDMETKCF ICGIGNDYFD TTPHGFETHT
     LQEHNLANYL FFLMYLINKD ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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