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Database: UniProt
Entry: G1MCB4_AILME
LinkDB: G1MCB4_AILME
Original site: G1MCB4_AILME 
ID   G1MCB4_AILME            Unreviewed;      1632 AA.
AC   G1MCB4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016992, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000016992}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000016992}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000016992}.
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DR   EMBL; ACTA01076158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01084158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01092158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01100158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01108158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01116158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01124158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01132158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01140158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000016992; -.
DR   Ensembl; ENSAMET00000017688; ENSAMEP00000016992; ENSAMEG00000016043.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G1MCB4; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     76     93       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    114    135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    147    167       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    224       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    312    334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    464    484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    528    546       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    589    611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    667    689       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1219   1237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1257   1277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1289   1307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1350   1372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1462   1487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1543   1561       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1573   1596       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       75    345       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      462    698       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1218   1493       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1539   1619       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      692    718       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1632 AA;  184290 MW;  D125A7772868142A CRC64;
     VVGSKGSEGP GGLQPGQRVL YKQSIAQRAR TMALYNPIPV KQNCFTVNRS LFVFSEDNVV
     RKYAKRITEW PPRTPFEYMI LATIIANCIV LALEQHLPDG DKTPMSERLD DTEPYFIGIF
     CFEAGIKIIA LGFVFHKGSY LRNGWNVMDF VVVLTGILAT AGTDFDLRTL RAVRVLRPLK
     LVSGIPSLQV VLKSIMKAMV PLLQIGLLLF FAILMFAIIG LEFYMGKFHK ACFPNSTDPD
     PVGDFPCGKE APARLCEGDT ECREYWPGPN FGITNFDNIL FAILTVFQCI TMEGWTDILY
     NTNDAAGNTW NWLYFIPLII IGSFFMLNLV LGVLSGEFAK ERERVENRRA FLKLRRQQQI
     ERELNGYLEW IFKAEEVMLA EEDKNAEEKS PLDAVLKRAA TKKSRNDLIH AEEGEDRFAD
     LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRVVK AQSFYWVVLC VVALNTLCVA
     MVHYDQPQRL TTALYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD FGVIVGSIFE
     VVWAAIKPGT SFGISVLRAL RLLRIFKVTK YWSSLRNLVV SLLNSMKSII SLLFLLFLFI
     VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL TGEDWNAVMY HGIESQGGVS
     KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE
     VADVSPMSAA NISIAAARPQ NSAKARSVWE QRASQLRLRN LRASCEALYS EMDPEERLRY
     ATTRHLRPDM KTHLDRPLVV ELGRARTRMR KRRQRRRRAR SRSRTGTRRR SSGTTSPSEG
     VRMRMXWAGS KAIILRHRGG KGGMGEGNCW DWFGTCWRGK SIVGQGKEKI GEPEGGLRRP
     LGEPHCELEA SGIVGVGPVH ALPSTCLQKV EGQPEDADNQ RNVTRMGSQP SDGDHGCSHG
     PEEPVTIMCH EVHRCPEAFP GETERPQKQH GHARPDEDLG LDHKITKAQL NTENPVDWDK
     ARVAPLLSKD LIGIKSNSFD WTLAVATHFR PFTSAPPGGL PLTTGGRGQE VDIHFPSDLF
     GVLYMCVNPY KVLARSRPHE GTEGENPKRG PPGLPGSEEC LWSRAGPRSS LSCWPEVSAE
     ASGAVSPGSH TIPFLKEALS PEPGGNVDLE SQAEGKKEAE ADDVMRSGPR PIVPYSSMFC
     LSPTNLLRRF CHYIVTMRYF EMVILVVIAL SSIALAAEDP VRTDSPRNNV LKYMDYIFTG
     VFTFEMVIKM IDLGLLLHPG AYFRDLWNIL DFIVVSGALV AFAFSGSKGK DINTIKSLRV
     LRVLRPLKTI KRLPKLKAVF DCVVTSLRNV LNILVVYVLF MLIFAVIAVQ LFKGKFFYCT
     DESKGLERDC RGQYLDYEKE EVEAQPRQWK KYDFHYDNVL WALLTLFTVS TGEGWPMVLK
     HSVDATYEEQ GPSPGYRMEL SIFYVVYFVV FPFFFVNIFV ALIIITFQEQ GDKVMSECSL
     EKNERACIDF AISAKPLTRY MPQDKQSFQY KTWTFVVSPP FEYFIMAMIA LNTVVLMMKF
     YDAPYEYELM LKCLNIVFTS MFSMECVLKI IAFGVLNYFR DAWNVFDFVT VLGSITDILV
     TEIAEDKNLL NL
//
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