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Database: UniProt
Entry: G1MEH2_AILME
LinkDB: G1MEH2_AILME
Original site: G1MEH2_AILME 
ID   G1MEH2_AILME            Unreviewed;      1811 AA.
AC   G1MEH2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 50.
DE   SubName: Full=Kinesin family member 1A {ECO:0000313|Ensembl:ENSAMEP00000017750};
GN   Name=KIF1A {ECO:0000313|Ensembl:ENSAMEP00000017750};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000017750, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000017750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000017750}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00283, ECO:0000256|SAAS:SAAS00583243}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000017750}.
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DR   EMBL; ACTA01115223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01123223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01131223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01139223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9646.ENSAMEP00000017750; -.
DR   Ensembl; ENSAMET00000018473; ENSAMEP00000017750; ENSAMEG00000016731.
DR   eggNOG; KOG0245; Eukaryota.
DR   eggNOG; COG5059; LUCA.
DR   GeneTree; ENSGT00890000139327; -.
DR   InParanoid; G1MEH2; -.
DR   OMA; HCVFRSD; -.
DR   OrthoDB; EOG091G009V; -.
DR   TreeFam; TF105221; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR032405; Kinesin_assoc.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH_dom-like.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008984; SMAD_FHA_domain.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   Pfam; PF16183; Kinesin_assoc; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00129; KISc; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF50729; SSF50729; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT   DOMAIN        5    354       Kinesin motor. {ECO:0000259|PROSITE:
FT                                PS50067}.
FT   DOMAIN      556    612       FHA. {ECO:0000259|PROSITE:PS50006}.
FT   DOMAIN     1696   1794       PH. {ECO:0000259|PROSITE:PS50003}.
FT   NP_BIND      97    104       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00283}.
FT   COILED      470    497       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1811 AA;  203218 MW;  820F097984780F9E CRC64;
     MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT
     SPEDVKYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP
     QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGHLRVRE HPLLGPYVED
     LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK
     VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK
     TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI
     NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDSECLCPP VLGRTARHVS DLENNNRNRG
     GVELSPAPDN LSTVTNALVG MSPSSSLSAL SSRAASVSSL HERILFAPGS EEAIERLKET
     EKIIAELNET WEEKLRRTEA IRMEREALLA EMGVAMREDG GTLGVFSPKK TPHLVNLNED
     PLMSECLLYY IKDGITRVGR EDAERRQDIV LSGHFIKEEH CVFRSDSRGG SEAVVTLEPC
     EGADTYVNGK KVTEPSILRS GNRIIMGKSH VFRFNHPEQA RQERERTPCA ETPAEPVDWA
     FAQRELLEKQ GIDMKQEMEQ RLHELEDHPQ REARVGGRGR VCTRVDYESK LEALQKQMDS
     RYYPEVNEEE EEPEDEVQWT ERECELALWA FRKWKWYQFT SLRDLLWGNA IFLKEANAIS
     VELKKKVQFQ FVLLTDTLYS PLPPDLLPPE AAKDRETRPF PRTIVAVEVQ DQKNGATHYW
     TLEKLRQRLD LMREMYDRAA EVPSSVIEDC DNVVTGGDPF YDRFPWFRLV GSNSYPLLNT
     CMSERMAALT PSPTFSSPDS DATEPAEEQS VGEEEEEEDL EDDVFPEHAL CDGRDPFYDR
     PPLFSLVGRA FVYLSNLLYP VPLVHRVAVV SEKGEVKGFL RVAVQATSAD EEAPDYGSGV
     RQSGTGSPST TSILFQSESC PVVGMSRSGT SQEELRIVEG QGQGADAGPS ADEVNNNTCS
     AAAPPEGLLL DSPEKAALDG PLDAALDHLR LGSTFTFRVT VLQASSISAE YADIFCQFNF
     IHRHDEAFST EPLKNTGRGP PLGFYHVQNI AVEVTKSFIE YIKTQPIVFE VFGHYQQHPF
     PPLCKDVLSP LRPSRRHFPR VMPLSKPVPA TKLSTLARPC PGPCHCKYDL LVYFEICELE
     ANGDYIPAVV DHRGGMPCMG TFLLHQGIQR RITVTLLHET GSHIRWKEVR ELVVGRIRNT
     PETDESLIDP NILSLNILSS DYIHPAQDDR SLLPSRTFYQ FEAAWDSSMH NSLLLNRVTP
     YREKIYMTLS AYIEMENCTQ PAVITKDFCM VFHSRDAKLP ASRSIRNLFG SGSLRASESN
     RVTGVYELSL CHVADAGSPG MQRRRRRVLD TSVAYVRGEE NLAGWRPRSD SLILDHQWEL
     EKLSLLQEVE KTRHYLLLRE KLETTQRPGP EAPSPASSED SGSHGSSSPS SPLSAEGRPS
     PPEAPNERQR ELAVKCLRLL THTFNREYTH SHVCISASES KLSEMSVTLL RDPSMSPLGA
     ATLTPSSTCP SLVEGRYGAA ELRTPQPCSQ PASPEPEPVP EADSKKLPSP ARAAEADKEP
     QRLLVPDIQE IRVSPIVSKK GYLHFLEPHT AGWAKRFVVV RRPYAYLYNS DKDAVERFVL
     NLSTAQVEYS EDQQAMLKTP NTFAVCTEHR GILLQANSDK DMHDWLYAFN PLLAGTIRSK
     LSRRRSAQMR V
//
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