ID G1MGE8_AILME Unreviewed; 777 AA.
AC G1MGE8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Rho guanine nucleotide exchange factor 38 {ECO:0000313|Ensembl:ENSAMEP00000018430.2};
GN Name=ARHGEF38 {ECO:0000313|Ensembl:ENSAMEP00000018430.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000018430.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000018430.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000018430.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011229433.1; XM_011231131.2.
DR AlphaFoldDB; G1MGE8; -.
DR STRING; 9646.ENSAMEP00000018430; -.
DR Ensembl; ENSAMET00000019171.2; ENSAMEP00000018430.2; ENSAMEG00000017435.2.
DR GeneID; 100468431; -.
DR KEGG; aml:100468431; -.
DR CTD; 54848; -.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00950000183088; -.
DR HOGENOM; CLU_005159_1_0_1; -.
DR InParanoid; G1MGE8; -.
DR TreeFam; TF317245; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd07589; BAR_DNMBP; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12141; SH3_DNMBP_C2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF17; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 93..284
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 326..536
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 582..645
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 713..776
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 35..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 88517 MW; FAC002FC031C5EFC CRC64;
MEPKEATGKE NMGTKKKNLT FLRPRLYMLE RRKTDTVVDS SVSGDHSGTL RRSQSDRTEY
SQKLQEKMTP QAGGSATETL TQEEHQMQRM MAKRSKIIKE LIQTEKDYLN DLELCIREVV
QPLRNKQIDR LDVDSLFSNI ESVHQISAKL LSLLEEATTD VQPAMQVIGE VFLQIKGPLE
DIYKTYCYHH DEAHSLLESY EKEEELKQHL SHCTQSLKKI YMQEGKPNLL DMGSLMIKPI
QRVMKYPLLL CELRGSTPPS HPDFRALGDA FTAVKEINVN INELKRRKDL VLKYKKNDED
ESLKDKLSKL NIHSISKKSK RVTNHLKILT RGEPQVKDNT FNREEKMFRS LEKTVRHCVK
NISLCLQHIQ EAMPLALQSV MELQEISCNK DKEERSHSEA PSNAPKPCGD FAAHLHRLVL
VPLSALLSLF TGPQKLIQKR YDKLLDCNSY LPRAAGDESD LAKKEYEALN AQLVEELQVF
NRGARKILCN CLCSFVALLR DLTLSAQQVC STVAPVPLLA SRISEIQNRV LEEVQNLNFV
KDNSTTFIER KLSFEKKKPV QILQEVPRQT DIHRSKLLST YSKEELYQAK RKCNATQEHD
VSLLEGELVA AVKQQDPLGS TSRWLVDTGI IKGYVYSSFL KPYNPAKVQK LDAENRFGDD
DFDNISLFVS SRPASDSVTG TPESSISDSS SSLSGTYGKF ETNGTDVDSS QEVDEQIFYA
VHAFQARSDH ELSLQEYQRV HILRFCDLSG NKEWWLAEAQ GQKGYVPANY LGKMTYA
//
