ID G1MGF2_AILME Unreviewed; 1022 AA.
AC G1MGF2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Kelch like family member 6 {ECO:0000313|Ensembl:ENSAMEP00000018434.2};
GN Name=KLHL6 {ECO:0000313|Ensembl:ENSAMEP00000018434.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000018434.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000018434.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000018434.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1MGF2; -.
DR STRING; 9646.ENSAMEP00000018434; -.
DR Ensembl; ENSAMET00000019175.2; ENSAMEP00000018434.2; ENSAMEG00000017427.2.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00940000161734; -.
DR HOGENOM; CLU_007130_0_0_1; -.
DR TreeFam; TF318080; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF211; GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1..185
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 604..807
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 819..939
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 524..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1022 AA; 117915 MW; 69A717E088C6BE5D CRC64;
MAPQELSRRL ATVITHVDEI MQQEIRPLVA VDIIEQLHRQ FAILSGGRGK DGAPIITFPE
FVGFKHLPEE DFLNVMTYLT SIPSVEAASI GFVIVIDRRR DKWSSIKASL TRIAVAFPGN
LQLIFILRPS RFIQRTFTDI GIKYYRDEFK MKVPIVVLNS VSDLHGYIDK SQLTEDLGGT
LEYRHSQWIN HRTAIENFAM TLKTTAKMLQ MFGACLATTD MPRGVLSTED LLMSHTRQRD
KLQDGLKLLG KQGTTLLSCI QEPATKSSTS KLNPNELENV ATMERLLLQL DETERAFNQF
WSEHHLKLNQ CLQLQHFEHN FYEVRLALDN LLVEQAEFID IGDSVIRVEQ LLKEHKNLEG
KGQETLEKAR LLAIIGDQLI QSHHYAVDSI RPRCVELRHL CDDFINENKK KYDILEKSLE
LHRQLDKVSQ WCEAGIYLLA SQAVDKCQSR EGVDVALNDI EAFLSTAKEY QLPSHTEFYS
QFELILTIDV KARAQEVLQK LGNVQEIFHK RQMSLMKLAA RQTRPVQPVA PHPESSPKWV
SPKTSQLSTL APLQRTSEEM FTGTLEKEDD ETKFEVKNEE ILESSHDGEN PEPEQLRSPE
NLSPTRLMIH DLLETEEIYI KEIKSIIDGY ITPMDFIWLK HLIPDVLQNN KEFLFGNIRE
LYEFHNRTFL KELKKCTENP ELLARCFLKR KEDLQIYFKY HKNLPRARAI WQECQDCTFF
GVCQRQLDHN LPLFKYLRGP SQRLIKYQML LKGLLDFESP EDLGIDPGDE GVLAKNGPKK
TKDSAFSAEL QQALAMIEDL IKSCELAVDL AAVTGCPDDI RKLGKLSMHG SFNVWTVHKD
RYKMKDFIRF KPSQRQIYLF ERGIVFCKIR MEPSDEGLAP HYSFKKSMKL MTLSIRQLGR
GSRRKFEIAN QNGLEKYIVQ APSKEIRDCW FSEISKLLME QQNNIKAKAL EWNLYPGLKI
WKELPAIRKS QSPAYMGLKI LMRMKTMANE SPPKAAPAGS LSQWKPLRSL KVQKKWKRKA
AL
//