ID G1MUB5_MELGA Unreviewed; 2478 AA.
AC G1MUB5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Teneurin transmembrane protein 2 {ECO:0000313|Ensembl:ENSMGAP00000002102.3};
GN Name=TENM2 {ECO:0000313|Ensembl:ENSMGAP00000002102.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000002102.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000002102.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000002102.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSMGAT00000002775.3; ENSMGAP00000002102.3; ENSMGAG00000002438.3.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR TreeFam; TF316833; -.
DR Proteomes; UP000001645; Chromosome 15.
DR Bgee; ENSMGAG00000002438; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF8; TENEURIN-2; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..149
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 401..433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 435..468
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 539..574
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 11..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 423..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 458..467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 543..553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 564..573
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2478 AA; 275212 MW; EE166B252E9C70A3 CRC64;
MAVISFSFSI SGPSNHHSQS TLRPPLPPPH NHSLSHHHSS ANSLNRNSLT NRRNQIHAPA
PAPNDLATTP ESVQLQDSWV LNSNVPLETR HFLFKTSSGT TPLFSSSSPG YPLTSGTVYT
PPPRLLPRNT FSRNAFKLKK PSKYCSWKCA ALSAIAAAVL LAILLAYFIG PWVTRNSSID
SGETEVGRKV TQEVPPGVFW RSQIHISQPQ FLKFNISLGK DALFGVYIRR GLPPSHAQYD
FMERLDGKEK WSVVESPRER RSIQTLVQNE AVFVQYLDVG LWHLAFYNDG KDKEVVSFST
VILDSVQDCP RNCHGNGECV SGVCHCFPGF HGADCAKAAC PVLCSGNGQY SKGTCLCYSG
WKGPECDVPI SQCIDPSCGG HGSCIEGNCV CSVGYKGENC EEVDCLDPTC SNHGVCVNGE
CLCSPGWGGI NCELPRAQCP DQCSGHGTYL SDTGLCSCDP NWMGPDCSVE VCSVDCGTHG
VCIGGACRCE EGWTGVACDQ RVCHPRCTEH GTCKDGKCEC REGWNGEHCT IGRQTTGTET
DGCPDLCNGN GRCTLGQNSW QCVCQTGWRG PGCNVAMETS CADNKDNEGD GLVDCLDPDC
CLQSTCQNSL LCRGSRDPLD IIQQSHSGSP AVKSFYDRIK LLVGKDSTHI IPEENPFNSS
LVSLVRGQVV TTDGTPLVGV NVSFVKYPKY GYTITRQDGM FDLVANGGSS LTLHFERAPF
MTQERTVWLP WNSFYAMDTL VMKTEENSIP SCDLSGFVRP DPVIISSPLS TFFSDAPGRN
PIVPETQVLH EEMEIPGTSI KLIYLSSRTA GYKSLLKIIM TQSLVPLNLI KVHLMVAVEG
HLFQKSFQAS PNLAYTFIWD KTDAYGQKVY GLSDAVVSVG FEYETCPSLI LWEKRTALLQ
GFELDPSNLG GWSLDKHHVL NVKSGILHKG NGENQFLTQQ PAVITSIMGN GRRRSISCPS
CNGLAEGNKL LAPVALAVGI DGSLFVGDFN YIRRIFPSRN VTSILELSNN PAHKYYLAVD
PVSGSLYVSD TNSRRIYKVK SLTGTKDLAG NSEVVAGTGE QCLPFDEARC GDGGKAVDAT
LMSPRGIAVD KYGLMYFVDA TMIRKVDQNG IISTLLGSND LTAVRPLSCD SSMDVSQVRL
EWPTDLAVNP MDNSLYVLEN NVPGIDYSLS KLAIHSALES ASAIAISHTG VLYISETDEK
KINRLRQVTT NGEICLLAGA ASDCDCKNDV NCNCYSGDDG YATDAILNSP SSLAVAPDGT
IYIADLGNIR IRAVSKNRPI LNSFNQYEAA SPGEQELYVF NADGIHQYTL SLVTGEYLYN
FTYSSDNDVT EVMDSNGNSL KVRRDASGMP RHLLMPDNQI VTLAVGTNGG LKLVSTQTLE
LGLMTYNGNS GLLATKSDET GWTTFYDYDH EGRLTNVTRP TGVVTSLHRE MEKSITIDIE
NSNRDDDVTV ITNLSSVEAS YTVVQDQVRN SYQLCNNGTL RVMYANGMSI SFHSEPHVLA
GTVTPTIGRC NISLPMENGL NSIEWRLRKE QIKGKVTVFG RKLRVHGRNL LSIDYDRNIR
TEKIYDDHRK FTLRIIYDQL GRPFLWLPSS GLAAVNVSYF FNGRLAGLQR GAMSERTDID
KQGRIVSRMF ADGKVWSYTY LEKSMVLLLQ SQRQYIFEYD SSDRLHAVTM PSVARHSMST
HTSVGYIRNI YNPPESNASV IFDYSDDGRI LKTSFLGTGR QVFYKYGKLS KLSEIVYDST
AVTFGYDETT GVLKMVNLQS GGFSCTIRYR KIGPLVDKQI YRFSEEGMVN ARFDYTYHDN
SFRIASIKPI ISETPLPVDL YRYDEISGKV EHFGKFGVIY YDINQIITTA VMTLSKHFDT
HGRIKEVQYE MFRSLMYWMT VQYDSMGRVT KRELKLGPYA NTTKYTYDYD GDGQLQSVAV
NDRPTWRYSY DLNGNLHLLN PGNSVRLMPL RYDLRDRITR LGDIPYKIDD DGFLCQRGSD
VFEYNSKGLL TRAYNKANGW NVQYRYDGLG RRASCKTNLG HHLQYFYADL HNPTRVTHVY
NHSNSEITSL YYDLQGHLFA MESSSGEEYY VASDNTGTPL AVFSINGLMI KQLQYTAYGE
IYYDSNPDFQ LVIGFHGGLY DPLTKLVHFT QRDYDVLAGR WTSPDYTMWK NIGREPAPFN
LYMFKSNNPL SNELDLKNYV TDVKSWLVMF GFQLSNIIPG FPRAKMYFVS PPYELTESQA
CENGQLITGV QQTTERHNQA FMALEGQVIS KKLHASIREK AGHWFATSTP IIGKGIMFAV
KEGRVTTGIS SIATDDSRKI ASVLNSAHYL EKMHYSIEGK DTHYFVKIGS ADSDLVTLAM
TSGRKVLDSG VNVTVSQPTL LINGRTRRFT NIEFQYSTLL INIRYGLTTD TLDEEKARVL
DQARQRALGS AWAKEQQKAR DGREGSRVWT DGEKQQLLNT GRVQGYEGYY VLPVEQYPEL
ADSSSNIQFL RQNEMGKR
//