ID G1MUN9_MELGA Unreviewed; 1028 AA.
AC G1MUN9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000256|ARBA:ARBA00014590};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX37 {ECO:0000313|Ensembl:ENSMGAP00000002269.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000002269.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000002269.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000002269.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR AlphaFoldDB; G1MUN9; -.
DR Ensembl; ENSMGAT00000002944.3; ENSMGAP00000002269.3; ENSMGAG00000002630.3.
DR GeneTree; ENSGT00550000074985; -.
DR HOGENOM; CLU_001832_0_0_1; -.
DR TreeFam; TF105654; -.
DR Proteomes; UP000001645; Chromosome 17.
DR Bgee; ENSMGAG00000002630; Expressed in pancreas and 17 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 139..306
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 336..588
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 19..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..452
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 115201 MW; EDA503D9F7EBD9BF CRC64;
MKLLYTTSKL GIGGRMYQPK RVLQEPGTAV PEKIRSISGA NKRRHSSDSE SEPEGESSCS
EEEKKEEKQE IEKLSSTNVN CAGKPEEDTK KPVVSQQAAP AVSSKPSCKP AVFVPVDRSP
EIQEARLKLP ILAEEQVIME AINENPIVVI CGETGSGKTT QVPQFLYEAG YTSSNGIIGI
TEPRRVAAVS MSQRVAKEMN LSHRVVSYQI RYEGNVTDET QIKFMTDGVL LKEVQKDFLL
LKYKVIIIDE AHERSMYTDI LIGLLSRIVP LREKKGLPLK LIIMSATLRV EDFTENTRLF
AVTPPVLQVD ARQFPVTVHF NKKTPLDDYS GECFRKVCKI HRMLPSGGIL VFLTGQAEVH
SLCRRLRKAF PFQKNSTAGD DDDRKESVEE MRKFKKSRRR RKAATLPQIN LDNYAVVPVD
EGDEDRDAET DDDIAGSDVD LDLGDGDSEE EEKSDSSLPL YVLPLYSLLA PEKQAKVFRP
PPPGTRLCVV ATNVAETSLT IPGIKYVVDC GKVKKRFYDK ITGVSSFRVT WISQASANQR
AGRAGRTEPG HCYRLYSSAV FMDFEKFSAP EITKRPVEDL ILQMKALNIE KVINFPFPTP
PPAEALAAAE ELLIALGALK EPPMTGRLKE QQAAKLSCPI SPLGRVMATF PVAPRYAKML
ALSRQHDCLP YTITIVSAMT VRELFEEFDR PAASEEETVK LKGKKGRLVQ MQRIWAGQGS
LQKLGDLMVM LGAVGACEYS GCTPKFCEEN GLRYKAMLEI RRLRGQLTTA VNSVCTDAGL
YVDPKMKPPT EAQATYLRQI VLAGLGDHLA RRVQAEELLD DKWKNAYKTA LLDDPVFIHP
SSVLFKQLPD FVVYQEIVET TKLYMKGVSA VEPEWIPALL PSYCHFGKPL ENPPPSYCPE
TGRIRCHRPS VFYRVSWQLP AVEVDYPEGI DRYKYFARFL LEGKVIEKLG SYSQCLLSSP
LIMLKTWSKL QPRTEFLLQA LVAENCDNRD ALLAAWKKNP KYLLAAYCQW IPEVMQEDIA
KQWPPVAL
//
