ID G1MV29_MELGA Unreviewed; 452 AA.
AC G1MV29;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Pleckstrin homology domain containing A2 {ECO:0000313|Ensembl:ENSMGAP00000002454.3};
GN Name=PLEKHA2 {ECO:0000313|Ensembl:ENSMGAP00000002454.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000002454.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000002454.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000002454.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; G1MV29; -.
DR Ensembl; ENSMGAT00000003133.3; ENSMGAP00000002454.3; ENSMGAG00000002802.3.
DR GeneTree; ENSGT00940000158064; -.
DR InParanoid; G1MV29; -.
DR TreeFam; TF329516; -.
DR Proteomes; UP000001645; Chromosome 24.
DR Bgee; ENSMGAG00000002802; Expressed in bursa of Fabricius and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR CDD; cd13270; PH1_TAPP1_2; 1.
DR CDD; cd13271; PH2_TAPP1_2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14336:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 2; 1.
DR PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 7..113
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 201..301
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 116..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 49654 MW; 94F13E19BAD2EAEA CRC64;
MPYLDRQNRI CGFLDIEENE TCGKFLRRYF ILDTQANCLL WYMDNPQNLA MGAGAVGSLQ
LTYISKVSVA TPKQKPKTPF CFVINALSQR YFLQASDQKD LQDWVEALNR ASKITVPKGG
AAAPPTTEVT KPPAVLQAQD RKPPVAYKTE IIGGVVVHTP ISISQNGGDG AEGSDPTAHP
LLRRSQSYIP ASASKPPAGP PAIKTGFCVK QGNVRKSWKR RYFVLDEFSI SYYKCEQDKE
PLRSILLKDI CKTHECLVKS GDLLMRDNLF EIITSSRTFY IQADSPEDMH SWIRAIAGAV
QALKTRPRVG ETHLYPIWHL AMILLTYEPQ STCRAVIPEL CKWLRKHRET NQHSLPAGDL
LHALLFHDQT RGQLGAIAAA GEENTLQGSS HRLAALDAGA TGQEAARGAQ PRCSVRAGAD
GARWSSCARS APAAPLRAAA SQGEDVPLRP GR
//
