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Database: UniProt
Entry: G1MVV9_MELGA
LinkDB: G1MVV9_MELGA
Original site: G1MVV9_MELGA 
ID   G1MVV9_MELGA            Unreviewed;      2195 AA.
AC   G1MVV9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   25-OCT-2017, entry version 49.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1E {ECO:0000313|Ensembl:ENSMGAP00000002810};
OS   Meleagris gallopavo (Common turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000002810, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000002810, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000002810}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000002810}.
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DR   STRING; 9103.ENSMGAP00000002810; -.
DR   Ensembl; ENSMGAT00000003498; ENSMGAP00000002810; ENSMGAG00000002963.
DR   eggNOG; ENOG410INF5; Eukaryota.
DR   eggNOG; ENOG410YD06; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G1MVV9; -.
DR   OMA; RRRHHMS; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001645; Chromosome 10.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     41     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     73     91       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    206    227       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    261       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    386    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    412    430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    512    534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    591    613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1035   1053       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1105   1124       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1170   1192       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1282   1307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1363   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1393   1416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1422   1440       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1487   1505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1580   1604       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1620   1655       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      609    636       {ECO:0000256|SAM:Coils}.
FT   COILED      980   1003       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2195 AA;  248736 MW;  77477C7B5A7FD1AA CRC64;
     PFEYMILATI IANCIVLALE QHLPEDDKTP MSRRLEKTEP YFIGIFCFEA GIKIVALGFV
     FHKGSYLRNG WNVMDFIVVL SGILATAGTH FNTHVDLRTL RAVRVLRPLK LVSGIPSLQI
     VLKSIMKAMV PLLQIGLLLF FAILMFAIIG LEFYSGKLHR ACYTNNSGEL EELDPPHPCG
     VQGCPPGYEC REWIGPNDGI TQFDNILFAV LTVFQCITME GWTTVLYNTN DALGATWNWL
     YFIPLIIIGS FFVLNLVLGV LSGEFAKERE RVENRRAFMK LRRQQQIERE LNGYRAWIDK
     AEEVMLAEEN KNAGTSALEV LRRATIKRNR TDAMNRDSSD EHCVDISSVG EPLSRSGLKG
     VDGASYLRHK ERLLRISVRH MVKSQVFYWI VLSLVALNTA CVAIVHHNQP AWLTHFLYYA
     EFLFLGLFLL EMSLKMYGMG PRLYFHSSFN CFDCGVTVGS IFEVVWAIFR PGTSFGISVL
     RALRLLRIFK ITKYWASLRN LVVSLMSSMK SIISLLFLLF LFIVVFALLG MQLFGGGFNF
     IDGTPSANFD TFPAAIMTVF QQILTGEDWN EVMYNGIRSQ GGVRSGMWSS IYFIVLTLFG
     NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPAIERDR
     RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ RTSQLRRHMQ MSSQEGINKD EPPLINPHAS
     IFRRKKPGDG VALEKCDEEQ GGKGERPPAE GPEQPAPGTN PGGGEDRRSP SPRARRDKEM
     WQHKACHGNC EPGEEGAGGG IEERARMRQS QRRSRHRKAR MEGKELTGAL ESRAGSQEMG
     LEEPCPAEGM QDGERRGDAA AALDLIQGEP EASRDPTSSF LSHRTNGAPT EEGSLPASAP
     EPARGWRAAW ASRTAAAQTP VSRPCWGERH WGASRTVSHS EPDLSSVTAN TEKATESTTI
     MIDSTVVQIS NKTDGEASPL KEAESKEDEE EMEKKKRKKE KSETGKAMVP HSSMFIFSTT
     NPVRRACHYI VNLRYFEMCI LLVIAASSIA LAAEDPVLTN SDRNKVLRYF DYVFTGVFTF
     EMVIKMIDQG LILQDGSYFR DLWNILDFIV VVGALVAFAL ANALGTNKGR DIKTIKSLRV
     LRVLRPLKTI KRLPKLKAVF DCVVTSLKNV FNILIVYKLF MFIFAVIAVQ LFKGKFFYCT
     DSSKDTEKDC IGNYVDHEKN KMEVKCREWK RHEFHYDNII WALLTLFTVS TGEGWPQVLQ
     HSVDVTEEDR GPSRSNRMEM SIFYVVYFVV FPFFFVNIFV ALIIITFQEQ GDKMMEECSL
     EKNERACIDF AISAKPLTRY MPQNRHTFQY RVWHFVVSPS FEYTIMAMIA LNTVVLMMKY
     YSAPYTYELA LKYLNIAFTM VFSLECVLKI IAFGFLNYFR DTWNIFDFIT VIGSITEIIL
     TDTKLVNTSS FNMSFLKLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF
     IYAIIGMQVF GNIKLDEESH INRHNNFRSF LGSLMLLFRS ATGEAWQEIM LSCLEGKGCE
     PDTTATSGQN ENERCGTDLA YVYFVSFIFF CSFLMLNLFV AVIMDNFEYL TRDSSILGPH
     HLDEFVRIWA EYDRAACGRI HYTEMYEMLT LMSPPLGLGK RCPSKVAYKR LVLMNMPVAE
     DMTVHFTSTL MALIRTALDI KIAKVQGGAD WQQLDSELQK EILTIWPHLS QKMLDLLVPM
     PKTSDLTVGK IYAAMMIMDY YKQSKAKKQR QQLEEQKNAP MFQRMEPSSL PQEIISNAKA
     LPYLQQDTLT GLSSRSGFPS LSPLSPQEIF QLACMDPAQG QFQEHQSLEP EVREFQRVQP
     SNRGSYLPVD TQDHAVSGRA SSMPRLTVDP QVVTDTSSMR RSFSTIRDKR TNTSWLDEFS
     MERSSDNTYK SRRRSYHSSL QLSARRLNAD SGHRSEGHRS GGRERGRSKE RKHLLSPDIS
     RCNSEERSPQ AHDESPERRR ESRSPSEGRS QTRRERQGTG SLSESSIPSI SDTSTPRRGR
     RQLPPVPPKP RPLLSYASML RHAAGDASPP PDETEGGSPL LSKEPNAAGL TESSSSPAGK
     PSRPSTPQRY ISEPYLALHD DSHASDCGEE ETLTFEAAVA TSLGRSNTIG SAPPLRHSWQ
     MPNGHYRRRR RGAGQGVMCG ASIDVLSDTE EDDKC
//
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