ID G1MWE6_MELGA Unreviewed; 860 AA.
AC G1MWE6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Villin like {ECO:0000313|Ensembl:ENSMGAP00000003069.2};
GN Name=VILL {ECO:0000313|Ensembl:ENSMGAP00000003069.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000003069.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000003069.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000003069.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR RefSeq; XP_003206980.1; XM_003206932.3.
DR RefSeq; XP_019471764.1; XM_019616219.1.
DR RefSeq; XP_019471765.1; XM_019616220.1.
DR RefSeq; XP_019471766.1; XM_019616221.1.
DR RefSeq; XP_019471767.1; XM_019616222.1.
DR AlphaFoldDB; G1MWE6; -.
DR Ensembl; ENSMGAT00000003763.2; ENSMGAP00000003069.2; ENSMGAG00000003270.2.
DR GeneID; 100542073; -.
DR KEGG; mgp:100542073; -.
DR CTD; 50853; -.
DR GeneTree; ENSGT00940000160253; -.
DR HOGENOM; CLU_002568_3_1_1; -.
DR InParanoid; G1MWE6; -.
DR TreeFam; TF313468; -.
DR Proteomes; UP000001645; Chromosome 6.
DR Bgee; ENSMGAG00000003270; Expressed in proventriculus and 12 other cell types or tissues.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977; VILLIN; 1.
DR PANTHER; PTHR11977:SF30; VILLIN-LIKE PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 6.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 794..860
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 759..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 97230 MW; A430BF86E5C0C91D CRC64;
MADGDTNLPT IERRLGLQIW SIENMKMVPV PEKAYGTFFE GDCYVILHSK RTSRGTAVDL
HYWIGKDSSQ DEQGAAAMYV TQLDAALRGS PVQHREVQGH ESETFQSYFR NGIIYKKGGV
ASGFKHVETN MYNIKRLLHV KGKKHVSATE VALSWDSFNK GDVFLLDLGK VLIQWNGPNC
SIAEKSRGLA LARSIRDSER GGRAQIGIID NEKDSPDLLK IMKMVLGERH GELRDAIPDT
KADELQKANV RLYHVYEKDN DLVVQEIATR PLTQDLLQHE DCYILDQGGF KIYVWRGKAS
NQEEKKAAFT RAVGFIQAKG YSSSTNIEVI NDGAESAMFK QLFQRWTEKD ETQGLGKVYT
VGKTAKVEQV KFDTTQLHAR PELAAEQRMV DDASGDVEVW RIEDLQMQPV DPKTYGQFYG
GDCYLVLYTY LRSGRPHYVL YMWQGRHASV DEITACALNA IELDKKHGDE AVQVRVTMGK
EPAHFLAIFK GKLIIYEGGT SRAQKCNPER AVRLFQVRGT NEMNTKATEV PARASSLNSN
DVFLLATNQV CYLWCGKGCS GDEREMAKMV ADIVSRRDKH TILEGQEPAE FWEALGGKAP
YASEKRFQEQ ITHYQPRLFE CSNQTGRFIM TEVVDFCQED LDEDDVMLLD TWEEIFLWIG
KASNTYEKNE AVASAKEYLK THPAGRDLAT PIILVKQGCE PLNFTGWFNA WDPYKWSDGK
SYEEMKNSLG DVSALSEITV DLNNISLSKR TLSMTNLTSS STSSVSPEYK SHFNHNDGSS
YANSSSNGSP FTVPNDQGVY SREVLMNKTV DELPEGVDPT KKEYYLSDAD FHEIFGKSKH
EFYQMPKWKQ QNEKKQCGLF
//
