GenomeNet

Database: UniProt
Entry: G1MWL7_MELGA
LinkDB: G1MWL7_MELGA
Original site: G1MWL7_MELGA 
ID   G1MWL7_MELGA            Unreviewed;       627 AA.
AC   G1MWL7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   25-APR-2018, entry version 50.
DE   SubName: Full=SH2B adaptor protein 2 {ECO:0000313|Ensembl:ENSMGAP00000003167};
GN   Name=SH2B2 {ECO:0000313|Ensembl:ENSMGAP00000003167};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000003167, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000003167, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000003167}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   STRING; 9103.ENSMGAP00000003167; -.
DR   Ensembl; ENSMGAT00000003864; ENSMGAP00000003167; ENSMGAG00000003469.
DR   eggNOG; ENOG410IMWK; Eukaryota.
DR   eggNOG; ENOG41102PH; LUCA.
DR   GeneTree; ENSGT00530000063355; -.
DR   InParanoid; G1MWL7; -.
DR   OMA; YDTEFFR; -.
DR   OrthoDB; EOG091G04RI; -.
DR   TreeFam; TF323184; -.
DR   Proteomes; UP000001645; Chromosome 21.
DR   GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR   GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR   GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR   GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
DR   GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IEA:Ensembl.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0050851; P:antigen receptor-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0001922; P:B-1 B cell homeostasis; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR   GO; GO:0019222; P:regulation of metabolic process; IEA:Ensembl.
DR   CDD; cd10411; SH2_SH2B2; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015012; Phe_ZIP.
DR   InterPro; IPR036290; Phe_ZIP_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   InterPro; IPR030520; SH2B2.
DR   InterPro; IPR035058; SH2B2_SH2.
DR   PANTHER; PTHR10872; PTHR10872; 1.
DR   PANTHER; PTHR10872:SF4; PTHR10872:SF4; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF08916; Phe_ZIP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF109805; SSF109805; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN      422    520       SH2. {ECO:0000259|PROSITE:PS50001}.
SQ   SEQUENCE   627 AA;  68666 MW;  8EA67339E80B9FD2 CRC64;
     WNGAAMNGDA LCQEPSSPLP DWREFCELHA QAAAVDFAQK FCQFLKENPH YDTPGAEASF
     SHHFAANFLD IFSLEVSRVF VSDSPTNMEA PLGAGRYLSP AQQAQARKVS SYGQSRSSED
     VSVHASAKPK FKKGFSLRNM SLCVVDGMKE MWHRRSSPEP GAEAAPGTRR TEREPWGKEP
     ADPREKWTHK CWVSKSFKGK IHLQRCKCIN STSHVVQEDP SGAGCSLPAA EPFLHLIKRA
     QSYQAHEFFF YLPPPASKPK VSIPLSAIIE VRTTMPLEMP DKDNTFVLKV ENGAEYILET
     IDSLQKHSWV ADIQDCIDPG DSGDDIELAS CAQGACLPGR ASSCSCEFLA DDRCALPAAH
     NATTTAMPAP HGRGRDSVGE LLAHVPLESF LQTLESAPTA STHLAGEDSE VDTEINLSDF
     PWFHGTLSRI KAAQLVLFGG ARSHGLFVIR QSETRPGEYV LTFNFQGKAK HLRLSLNESG
     QCHVQHLWFQ SIFDMLRHFH THPIPLESGG AADITLRSYV VAQSLQPDAG PPPALVPQPP
     LCRTDPPPPH YFCNTAPAAP PVPPPTEGVA VPPAVPTPYH RLEGALGPRS DSAERRPEPA
     ATGTEDYHDA DGARSRTRAV ENQYSFY
//
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