ID G1MWT7_MELGA Unreviewed; 918 AA.
AC G1MWT7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=SH3 and PX domains 2B {ECO:0000313|Ensembl:ENSMGAP00000003247.3};
GN Name=SH3PXD2B {ECO:0000313|Ensembl:ENSMGAP00000003247.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000003247.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000003247.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000003247.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SH3PXD2 family.
CC {ECO:0000256|ARBA:ARBA00009628}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1MWT7; -.
DR Ensembl; ENSMGAT00000003946.3; ENSMGAP00000003247.3; ENSMGAG00000003508.3.
DR GeneTree; ENSGT00940000158396; -.
DR HOGENOM; CLU_013051_1_0_1; -.
DR TreeFam; TF329347; -.
DR Proteomes; UP000001645; Chromosome 15.
DR Bgee; ENSMGAG00000003508; Expressed in pancreas and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR CDD; cd06888; PX_FISH; 1.
DR CDD; cd12075; SH3_Tks4_1; 1.
DR CDD; cd12076; SH3_Tks4_2; 1.
DR CDD; cd12078; SH3_Tks4_3; 1.
DR CDD; cd12018; SH3_Tks4_4; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR001655; P47PHOX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037961; SH3PXD2_PX.
DR InterPro; IPR035477; SH3PXD2B_SH3_1.
DR InterPro; IPR035478; SH3PXD2B_SH3_2.
DR InterPro; IPR035479; SH3PXD2B_SH3_3.
DR InterPro; IPR035480; SH3PXD2B_SH3_4.
DR PANTHER; PTHR15706:SF25; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 3.
DR PRINTS; PR00498; P47PHOX.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 15..139
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 174..233
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 271..330
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 414..473
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 857..918
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 356..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..808
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 102739 MW; 70C56B1907BE7CFD CRC64;
MLPCTPWLML SHFAATGVSW VIPSLVSDFF LCSLQVYIIK VTWSNGSTEV IYRRYSKFFD
LQMQMLDKFP MEGGQKDPKQ RIIPFLPGKI LFRRSHIRDV AVKRLIPIDE YCKALIQLPP
YISQCEEVLQ FFETRPDDLT PPKEEPIGKK RSGFIQRTTS FLQRGADSAS VDPLVLEQYV
VVANYQKQES SEISLCVGQL VDIIEKNESG WWFVSTSEEQ GWVPATCLEA QDGVQDELSM
QPDEVPWRYW SLPRHVGRRR TLGDLYTSGW GQEEKYTVIY PYTARDQDEM NLDKGAVVVV
IQKNLEGWWK IRYQGQEGWA PASYLKKGNG EFSQKLGSGS STHSCALDLD GISRQQVVTS
REKDGQRDGR FDNRPLPNAD IRRKSPKMRQ RPPPRRDLTI PRGLNLPKPP VPPQVEEEYY
TIADFQTTIP DGISFQAGMK VEVIEKNLSG WWYIQIEEKE GWAPATFIDK YKKTSNASRP
NFLAPLPSEM AQLRLGDAAA ESSATEEATG PCRPLPEAPP NGMDCGTKWA KDWKGKEATE
SGDLAFTCGY EEISDRDVEE KPSLPPRKES IIKSEGELLE RQRPPPKPPG MILPMIPPKQ
SAAPKDSKKP ELKSEKSKLF QLKNEMGLEC GHKVSAKEVK KPNLRPIVKP TKPKAEPVED
KPEPITQNPF LKSRPQIKPK PTAAPRTDPP PADDKLDICS LRSKLRPAKC PEKPPEQDTT
ASESSCSNPA VAPEASGRFQ ERPSIESKAL PKSPPGPAVP LAARELAPQR PVVPPRRPPP
PKKTTSPVAG PPPEARASPL PGRPMLVPPK ARPFLSAAIQ DEAKVKSSVG PKVISKAVER
GEGRERTSAP FSNPDVSKEA LYVAVADFEG DEETNSFREG TLFEVREKNS SGWWFCKVLT
GGPCWEGWIP SNYLRKKP
//
