ID G1MYW6_MELGA Unreviewed; 1543 AA.
AC G1MYW6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN Name=LOC100548521 {ECO:0000313|Ensembl:ENSMGAP00000004180.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004180.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000004180.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000004180.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_010722927.1; XM_010724625.2.
DR Ensembl; ENSMGAT00000004893.3; ENSMGAP00000004180.3; ENSMGAG00000004348.3.
DR GeneID; 100548521; -.
DR KEGG; mgp:100548521; -.
DR GeneTree; ENSGT00440000034289; -.
DR HOGENOM; CLU_002290_0_0_1; -.
DR TreeFam; TF105060; -.
DR Proteomes; UP000001645; Chromosome 29.
DR Bgee; ENSMGAG00000004348; Expressed in bursa of Fabricius and 15 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd16498; RING-HC_BRCA1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR025994; BRCA1_serine_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF12820; BRCT_assoc; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PIRSF; PIRSF001734; BRCA1; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 24..66
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 131..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1430..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1346..1373
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1156..1172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1543 AA; 171794 MW; D3DC604D4D256B13 CRC64;
MDLSVIAIGD VQNVLSAMQK NLECPVCLDV IKEPVSTKCD HIFCRFCMFK LLSKKKKGVI
QCPLCKTEVT KRSLKENSRF KQLIEGLLEA ISAFELDTGV KFLSSHFPKT STEAATAELL
DNNSSVIQSK GFRNRKRSAK ENGQDSYTLG EANVDPELTG NRVEGCYLRN KKQKRGIEKG
VLIELGTDSS EELFILASDT GRLEDKEELE EPKSAEKYGS SCNTQSLKLG AKEIILPDVI
GETDFLNEAL SKKSMLNITE HVKSNQVNTV EGQSSPSNVF DADLLTEQCN EISNASPLKN
NYTSFSNNAE EMDAEESLCS TKNQELDFED GSESRLNKIK EKDICVLSVE DVEMYEPVND
SLLEKEPPVE KPQPKIPHCP TLHEVSRKRL KQSIQKVNEW FSKSNEILSS SSFQNDPSEA
TDASGEEDVS LSDKDSCISE KTNPIVDSVE FAVFERNKRW PKQTTYSIKD KIFGKTYERG
RKSNPSTILR DILPATKKDV AAEEKCLNNS REDGLKRKRK PARVLQPEDF MEKKDLEEAD
RCPQGINSSL GDAEKRKCDE NSAVKENSLL EKRKVSTLTE FEEGELQWKN AIEKVSGKPF
GQLELSNSDQ KSTKNACSAA KGCRRSTRTR CAIHLGDNRN PDSFDPAEPL IDSYPSSEEP
NKVDCEQRQV RRSRRLQLLS KEITKETGEM RITKEARNSD SGPEGSVFGV ERNVLVHDSQ
CKDLKQQDIL SYTSLTDRNG ADLEANGMQI SSKNSADMVK NTSLFNPTFS CEHSNFNSPS
LKAGSQEGEM LGRLFLLQSP SKTVLDTASI LTEEKRSGSC TAFPQDKGCC SQNVPEDFRI
EKSPITKNVS ELTVEAEDSE LDTQHLRNIF RSSKRQSFSL YPAPMKTCTT DDVESGKLNT
LCPDQVEKRC SKYFMTENLQ EKKTTAENLS SVCEKFKTCE SACVSPVSCF VSSAECVHAA
EHQEDILKVA NHGNIVRSNR NLSDQSNTEE RAFQRTDLNT VSETYFSSES NQVENAEIVD
GKEPMQHFQP SPMVCPTVHQ QNPAEFNCEV TGKKSSKKER SLVKGNEERV IQTVNTGLSE
YLVREVLEES LKGRSDFTDL SETPDGLLCS DNDTEDSTSF YVTNRKDTSA VFVKRSGAVL
MKEVNDSVVS CKPRSEGIQR SRRRAQKLQS SDEESSEDED LPCFQELMFG KSVSTPLQIK
KQVTSVVRSS ANPSMLPCSE CLNENNEQKT LEAALSNECV SPSQESECSV NLFSSQSNIS
EESVDGAHEM RKTLTQVSNI NKSKEALHSS SGGLKRRKNN SYDEYQEDPN MGANLGEASG
YDSETSRVED SHEPFSQGEI LSTQQKNAMQ NNLKKLQQEM AVLEAVLKQH GSQDTEVLPL
CRELPYASSG GTLGMEQMRQ EMENVSEHDS ETKLSKASVL PVLCGNVTRN PNSSSSSVKH
PCPQTAEATN NSAVAQSDNK SNVQVCESKR NVCFPTSVLH NAAGKENVAS SGTTYRTEMS
IVASGLNQSE HVSIFWNVWR LAVVLNLEIR SYRGNQSYRT YCL
//
