GenomeNet

Database: UniProt
Entry: G1MZ44_MELGA
LinkDB: G1MZ44_MELGA
Original site: G1MZ44_MELGA 
ID   G1MZ44_MELGA            Unreviewed;      2033 AA.
AC   G1MZ44;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSMGAP00000004277};
OS   Meleagris gallopavo (Common turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004277, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000004277, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000004277}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000004277}.
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DR   STRING; 9103.ENSMGAP00000004277; -.
DR   Ensembl; ENSMGAT00000004991; ENSMGAP00000004277; ENSMGAG00000004453.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1MZ44; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001645; Chromosome 6.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    224    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    386    414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    727    745       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    757    780       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    792    816       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    837    870       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    925    950       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1224   1242       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1263   1279       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1291   1310       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1355   1375       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1465   1488       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1547   1565       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1577   1599       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1611   1630       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1678   1700       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1767   1790       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    420       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      477    676       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      727    954       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      964   1218       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1222   1497       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1546   1800       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      411    445       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2033 AA;  231351 MW;  63AAD4D1A39AAC48 CRC64;
     MADFLLPPGT NSFHRFTPES LAAIEKRIAE KLARNAKQEY REQLGEEEKP QPQFDLQACK
     KLPDIYGTVP PELIGEPLED IDPFYNDRKT FVVLNKGKTI FRFSATPALY ILSPFHPVRR
     AAIKILIFTL FSMFIMCTIL TNCVFMAQSE TPSWNKYVEY TFTGIYTFES LIKILARGFC
     MTEFTFLRDP WNWLDFSVIV MAYITEFVDL GNVSALRTFR VLRALKTISV ISGLKTIVGA
     LIQSVKKLAD VMILTVFCLS VFALIGLQLF MGNLRHKCVR DYTQFNFTNG TLYLDGRTWN
     NSEEFLNDPV NYFIKNGTED VLLCGNSTDA GTCPEGYICL KAGENPDHGY TSFDTFGWAF
     LSLFRLMTQD YWERLYQQTL RSAGKIYMLF FMLVIFLGSF YLVNLILAVV AMAYEEQNQA
     TIAETEEKER KFREAMEMLK KEQEALAAKG IDSMSLSSLE MSPLASKNAK ERRNRRKKKK
     SLGAEEYGED QRNSKSEYDD SQRRMTLLGI SYGPSANLVK RRTSHGSIFS FRLRGRDTGS
     ETDFADDEIS TAGENESHRG SLLIPRSGRR PSIQSQVSHS SHPTTPSYTQ TGKRNSSVDC
     NGVVSLIGGG TGALNPDPTS PAGLLLPPVI MEKPGTGDLT SPSDEASKKQ LLMPHRPSVD
     HSDEPFQRQR AVSAVSIITS ALEELEESHQ KCPPCWNHFA VKFLIWDCCP FWLLIKKFVK
     FVVMDPFTDL TITLCIVLNT LFMALEHYKM TKEFDHMLYI GNLVFTGIFT AEMIFKVIAL
     DPYYYFQQGW NIFDSIIVIL SLMELGLSSM GNLSVLRSFR LLRVFKLAKS WPTLNTLIKI
     IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKSYLDNVKK ISTTGNLPRW HMNDFFHSFL
     IIFRILCGEW IETMWDCMEV AGQPLCLLVF LLVMVIGNLV VLNLFLALLL SSFSADNLSA
     PDEDGEMNNL QLAFARINRG LQYVKHTTWD FCCNVLRHPK TTAEKKAMMK LAAQNTGALN
     NCVNSHPTAE LGKDMENHKE NHTEDGMNKN MEKHLGITDN DDFMTNPDLS ICVPIAVGES
     DIEEEDEEQS TFTEMEQNKQ EKQLQLRGQR CQSPGARSQN SEICEELSEL HVDKQLKAEP
     PPPGCKGRPE DDLKSNGSSH EATNTNMRCE QIPEFAEELM EPEDCFPEVC VRFFPCCSVD
     ISKFPGKIWW RLRKTCYRIV EHNWFETFII FMILLSSGAL AFEDIYLEDR KNIKTMLEYA
     DKIFTYIFVL EMLLKWVAYG FKKYFTNAWC WLDFLIVDVS LISLIANTLG YSEMGPIKSL
     RTLRALRPLR ALSRFEGMRV VVNALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFGK
     CINKTEGDMP LDSKIINNMS DCILYNVSGT FYWTKVKVNF DNVGAGYLAL LQVATFKGWM
     DIMYAAVDSR ECEEQPEWEC NLYMYLYFVI FIIFGSFFTL NLFIGVIIDN FNQQKKKLGG
     QDIFMTEEQK KYYNAMKKLG SKKPQKPIPR PLNKYQGFIF DVVSKQAFDV SIMILICLNM
     VTMMVETDDQ SQEKVNILHK INMLFVAIFT GECIFKMLAL RHYYFTNGWN IFDFVVVILS
     IVGTVLSDII QKYFFSPTLF RVIRLARIGR ILRLIRGAKG IRTLLFALMM SLPALFNIGL
     LLFLVMFIYA IFGMANFAYV KKEYGIDDMF NFQTFANSML CLFQITTSAG WDGLLNPILN
     TGPPYCDPNL PNANGSKGDC GSPAVGILFF VTYIIISFLI VVNMYIAIIL ENFSVATEES
     TEPLSEDDFD MFYEIWEKFD PEATQFIEYS ALSDFADALS EPLRIAKPNK IKLIAMDLPM
     VSGDRIHCLD ILFAFTKRVL GESGEMDALK IQMEEKFMAA NPSKISYEPI TTTLRRKQEE
     VSAIVIQRAY RRHLFRRSMK QASYLYRHRT FDGSILEDDA PEKEGLIAFM MNENYGRPID
     KSETLSSTSF PPSYDSVTRG TSENLQLKLT DSSKSDEAID CLLSPDRDKE SIV
//
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