ID G1MZZ9_MELGA Unreviewed; 1648 AA.
AC G1MZZ9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSMGAP00000004676.3};
GN Name=IQGAP2 {ECO:0000313|Ensembl:ENSMGAP00000004676.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004676.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000004676.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000004676.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMGAT00000005397.3; ENSMGAP00000004676.3; ENSMGAG00000004823.3.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_2_1_1; -.
DR InParanoid; G1MZZ9; -.
DR TreeFam; TF313078; -.
DR Proteomes; UP000001645; Chromosome Z.
DR Bgee; ENSMGAG00000004823; Expressed in proventriculus and 17 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0071933; F:Arp2/3 complex binding; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0070493; P:thrombin-activated receptor signaling pathway; IEA:Ensembl.
DR CDD; cd05131; RasGAP_IQGAP2; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 31..146
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 988..1221
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 155..182
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1648 AA; 189209 MW; 2ACF2D04A2F5C016 CRC64;
MVLYLAIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLEEELP PTTELEEGLR
NGVYLAKLAK FFAPNLVSDK KIYDVKQERY KRSGLHFRHT DNTVQWLRAM ESIGLPKIFY
PETTDVYDRK NIPRMIYCIH ALSLYLFKLG LAPQIQDLLG KVDFTEEEIS NMRKELEKYG
IQMPSFSKIG GILASELSVD EAALHAAVIA INEAIEKGIA EQTIATLRNP NAMLLNVDEE
LAQDYQNELF DAKRRKQSNA RLKNGTISEE ERDVYEELLT QAEIQGNINK INIHMALVQV
NEAIDRQDEV ALMAGLNRPA LSLLEVLPQN SSWYLLQLCD SKEQKMQIAG VPNMLDKSEI
QKEVSVANAE AEAHKLKLIA VDNINTAIRN CDPSKTLVAL MKPEAQLPVV HSFAAVVYQT
ELFNLQQNAV NYLAHDELSV AVEMLSAVVL LNQALENKDI QMIRNHLRNP CTGFNNLEEE
NLQRYADTLL SIKSEASSQG QDYLSWNDIQ NCIDLVNMQI QEENERIIAI DHINEAIDQG
NAEKTLEALL MPTAKLQDVR PENAKHYQDV LHDAKTQKRK ETQDESAVLW LDEIQKGISD
ANSNIKEAAI LAVGISMINR SLEKGDSQPI LMTLQSKFGL RVVSECAETY FKNLSEAQKL
KTKDDSNESP WIKIIMKNMY SYYYNVETEE GTCVVPEGVL PKTSWLTAEE IQNIVGQVTA
DYNREQLWLA NESLIVRLQA QARGFLVRRN FRDRKAYLRN QEPSAIKIQA FWKGFKQRKS
YIDRLKMLQS NVAAIIKIQS WVKMWLARRA YRKRLQYFKD HNEEIVKIQA FLRANKARED
YRTLIGAENP PLPVLRKFAY LLDQSDLDFQ EELEVTRLRE EVVTKIRSNQ QLEKDLNLMD
IKIGLLVKNR ITLQDVVLHS KKLNKKSKNQ LEEMVMVDKQ GIKGLSKERR KKLEAYQHLF
YLLQTNPTYL AKLIFQMPQN KSTKFMDTVI FTLYNYASNQ REEYLLLKLF KTALEEEINS
KVDQIQDIVT GNPTVIKMVV SFNRGARGQN TLRQLLAPVV KEIMEDKSLI INTSPVDVYK
SWVNQLEMQT GEASKLPYDV TTEQALAHTE VVNKLESSIQ SLRAVTDKVL TSIFSSLSMM
PYGMRYIAKV LKSSLHEKFP DATEDELLKI VGNLLYYRYM NPAIVAPDGF DIIDMTAGGQ
IHPDQRRNLG CVAKVLQHAA SNKLFEGESE HLSSMNTYLS QTYQKFRNFF QTACDVPEPE
EKFNIDEYSD MVTLSKPVIY ISIEEIINTH SLLLEHQDAI ATEPNDLLNE LLEGLGPVPD
VESFLGEGSV DPNDPNKEST LNQLAKTEIS LSLTSKYELR EGEDQDLKSL MIKTKRLIVD
MIRTQPGDTL SEILETTATA QQESEHSKLV EKRAILDSKT PEKMKRSQSI FEDGQLPIEQ
KKRKIQRNLR TLEQAGLVSS ATKYQEIINE IAKDIRNQRR YRHHRKAELV KLQQTLNALN
SKTAFYEEQI NYYNTYIKTC LDNLTRKNSR RSIKVDGKEE VKGSKKLKQA SLKYTAARLH
EKGVILEIED LQTNQFKNVM FDITPGEEVG DFEIKAKFLG VEMEKVQLNF QDLLQMQYEG
VAVMKMFDKA KVNVNLLIFL LNKKFYGK
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