ID G1N038_MELGA Unreviewed; 742 AA.
AC G1N038;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Dipeptidyl aminopeptidase-like protein 6 {ECO:0000256|ARBA:ARBA00040948};
DE AltName: Full=Dipeptidyl peptidase 6 {ECO:0000256|ARBA:ARBA00042016};
DE AltName: Full=Dipeptidyl peptidase VI {ECO:0000256|ARBA:ARBA00041991};
GN Name=DPP6 {ECO:0000313|Ensembl:ENSMGAP00000004728.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004728.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000004728.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000004728.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019471787.1; XM_019616242.1.
DR AlphaFoldDB; G1N038; -.
DR Ensembl; ENSMGAT00000005449.3; ENSMGAP00000004728.3; ENSMGAG00000004869.3.
DR GeneTree; ENSGT00940000156280; -.
DR HOGENOM; CLU_006105_4_1_1; -.
DR InParanoid; G1N038; -.
DR TreeFam; TF313309; -.
DR Proteomes; UP000001645; Chromosome 6.
DR Bgee; ENSMGAG00000004869; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:Ensembl.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF20; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 74..440
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 522..725
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 742 AA; 85106 MW; 15A46A9333029198 CRC64;
MQCFHLQSSE DSFRFSSPTK KDCKVSCYSS RDNEFIYRNQ NGTVILRNVE TNNSTVLIEN
KKIVSLKAVR YEVSPDREYA LFAFDVEPMY RHSYAAHYVL SKIPHGDPQN LYPPEVSNAK
LQYAGWGPKG QQLIFIFENN IYYCAHVGKQ AIRVVSSGKE GVIFNGLSDW LYEEEILKTH
IAHWWSPDGT RLAYATINAS RVPTMEIPVY TGSLYPTVKT YHYPKAGMEN PTISLHVIGL
NGPTHDLEMI PPDDQRLRDY YITMVKWATS TKVAVNWLNR AQNFSILTLC DATTGVCTKK
HEDESEGWLH RQNEEPIFSK DGRKFFFVRA HPQGGRGKFY HVAMSSSQPN SSSDNLESIT
SGDWDVTKIL AYDEKRHKIY FLSTEDLPRR RHLYSASTNG NFNRQCLSCD LIENCTYFSA
SFSHNLEYFL LTCEGPRVPM VTVHSMTDAQ KIFELEVNEN VQLAVNDRQM PKVEYMEIKI
DDYKLPMQIL KPATFSDMAH YPLLLVVDGT PGNQIVTERF EVTWETVMVS LHNAIVLKFD
GRGSGFQGTK LLHEVKRRLG LLEEKDQLEA VRTMLKEHYI DKMRVGVFGK DYGGYLSTYM
LPAGEENQVF ACGAALSPLT DFKLYASAFS ERYLGLYGID NRVYEITRLE HRVSLLKEQT
FLIIHATADE KIHFQHTADL ITHLIKAKAN YSLQIYPDES HYFSNPALEQ HLYNSIVNFF
ASCFQVQDKL PIAPLKEEED ND
//
