ID G1N0T1_MELGA Unreviewed; 672 AA.
AC G1N0T1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Cyclic nucleotide gated channel subunit alpha 2 {ECO:0000313|Ensembl:ENSMGAP00000005060.3};
GN Name=CNGA2 {ECO:0000313|Ensembl:ENSMGAP00000005060.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000005060.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000005060.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000005060.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_019473757.1; XM_019618212.1.
DR RefSeq; XP_019473758.1; XM_019618213.1.
DR RefSeq; XP_019473759.1; XM_019618214.1.
DR AlphaFoldDB; G1N0T1; -.
DR Ensembl; ENSMGAT00000005787.3; ENSMGAP00000005060.3; ENSMGAG00000005170.3.
DR GeneID; 100543783; -.
DR KEGG; mgp:100543783; -.
DR GeneTree; ENSGT00940000155374; -.
DR HOGENOM; CLU_005746_12_0_1; -.
DR InParanoid; G1N0T1; -.
DR TreeFam; TF319048; -.
DR Proteomes; UP000001645; Chromosome 9.
DR Bgee; ENSMGAG00000005170; Expressed in ovary.
DR GO; GO:0060170; C:ciliary membrane; IEA:Ensembl.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:Ensembl.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF3; CYCLIC NUCLEOTIDE-GATED OLFACTORY CHANNEL; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Olfaction {ECO:0000256|ARBA:ARBA00022725};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 456..570
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 77024 MW; DF7C5CF856DEB318 CRC64;
MMARSNGLQL PGPCPSLPTR ARTDAQSTEL STSRTRLTQD ETLELRRGTP AYGGEQPAAP
PFQGRRALAR IVRLVLVLRD WASKSLQEEQ QRPDPFLERF QGPELQTVPA DASSDPEDEE
AEEKTKKKKW QSFVVDPAGD WYYRWLAVIA VPVLYNWCLL VARACFSDLQ KTYVVLWLVL
DYISDCIYTG DIVIRLRTGF LEQGLLVKDL KKLRDNYIYT LQFKLDVLSI LPTDVVYFAV
GLHRPELRFN RLLHFSRMFE FFDRTETRTS YPNIFRIGNL VLYILVIIHW NACIYYAISK
AIGFGEDTWV YPNVTDPEYG YLTREYVYCL YWSTLTLTTI GETPPPVRDE EYLFVIFDFL
IGVLIFATIV GNVGSMISNM NATRAEFQAK IDAIKHYMQF RKVSKDMETK VIKWFDYLWT
NKKAVDEREV LKSLPDKLRA EIAINVHLET LKKVRIFQDC EAGLLVELVL KLRPQVFSPG
DYICRKGDIG KEMYIIKEGK LAVVADDGTT QYALLTAGGC FGEISILNIK GSKMGNRRTA
NIRSLGYSDL FCLSKEDLME AVTEYPDAKK VLEERGREIL SKEGLLDESA EEESMEGKSV
EEKLDRLTLN LDTLHTRLGR LLTEYNDAQM KLKQRITVLE SQMRQQDLED FFSDSSDSLS
EVEGEATPTG LQ
//
