GenomeNet

Database: UniProt
Entry: G1N2Z7_MELGA
LinkDB: G1N2Z7_MELGA
Original site: G1N2Z7_MELGA 
ID   G1N2Z7_MELGA            Unreviewed;      1102 AA.
AC   G1N2Z7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE            EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
GN   Name=KDM4B {ECO:0000313|Ensembl:ENSMGAP00000006048.3};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000006048.3, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000006048.3, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA   Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA   Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA   Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA   Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA   Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA   Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA   Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA   Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000006048.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-
CC         [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-
CC         lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC         COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC         EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00000040};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC       {ECO:0000256|ARBA:ARBA00009711}.
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DR   AlphaFoldDB; G1N2Z7; -.
DR   Ensembl; ENSMGAT00000006794.3; ENSMGAP00000006048.3; ENSMGAG00000005999.3.
DR   GeneTree; ENSGT00940000159248; -.
DR   HOGENOM; CLU_001442_0_1_1; -.
DR   InParanoid; G1N2Z7; -.
DR   TreeFam; TF106449; -.
DR   Proteomes; UP000001645; Chromosome 30.
DR   Bgee; ENSMGAG00000005999; Expressed in thymus and 17 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005721; C:pericentric heterochromatin; IEA:Ensembl.
DR   GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:Ensembl.
DR   GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007420; P:brain development; IEA:Ensembl.
DR   CDD; cd15714; ePHD_JMJD2B; 1.
DR   CDD; cd15576; PHD_JMJD2B; 1.
DR   CDD; cd20464; Tudor_JMJD2B_rpt1; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.10.330.70; -; 1.
DR   Gene3D; 2.60.120.650; Cupin; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR034732; EPHD.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR003349; JmjN.
DR   InterPro; IPR040477; KDM4-like_Tudor.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR047483; Tudor_KDM4B_rpt1.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10694:SF7; [HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE; 1.
DR   PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR   Pfam; PF02373; JmjC; 1.
DR   Pfam; PF02375; JmjN; 1.
DR   Pfam; PF13831; PHD_2; 1.
DR   Pfam; PF18104; Tudor_2; 2.
DR   Pfam; PF13832; zf-HC5HC2H_2; 1.
DR   SMART; SM00558; JmjC; 1.
DR   SMART; SM00545; JmjN; 1.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00333; TUDOR; 2.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR   PROSITE; PS51805; EPHD; 1.
DR   PROSITE; PS51184; JMJC; 1.
DR   PROSITE; PS51183; JMJN; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          15..57
FT                   /note="JmjN"
FT                   /evidence="ECO:0000259|PROSITE:PS51183"
FT   DOMAIN          143..309
FT                   /note="JmjC"
FT                   /evidence="ECO:0000259|PROSITE:PS51184"
FT   DOMAIN          797..910
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51805"
FT   REGION          374..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          613..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..448
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..465
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1102 AA;  125132 MW;  464AC92CA3F80AB8 CRC64;
     MGSENPSPQN PGCKIMTFRP TLEEFRDFGK YVAYIESQGA HRAGLAKVIP PKEWKPRKTY
     DDIDDMVIPA PIQQVVTGQS GLFTQYNIQK KPMTVGEYRR LANSEKYCTP RHQDFEDLER
     KYWKNLTFVS PIYGADISGS LYDTDVEEWN IGNLNTLLDM VEHECGIIIE GVNTPYLYFG
     MWKTTFAWHT EDMDLYSINY LHFGEPKSWY AIPPEHGKRL ERLAKGFFPG SSQGCDAFLR
     HKMTLISPSI LKKYGIPFDR ITQEAGEFMI TFPYGYHAGF NHGFNCAEST NFATLRWIDY
     GKMATQCTCR KDMVKISMDV FVRVLQPERY DLWKQGKDIA VLDHMKPTAL TSPELDAWNE
     TKADLKAKLL RRIGDEEEDN KHRSHRKRSQ PRRHKTEDQK SLGDVMAIET ALEDVKVKEE
     LKRGPDLEEE DRSKVVEGEG DSKVKARPPK VKGERKKKHL FHQHQHHLQT SQPLQQQQQQ
     QLPLPPAVQQ QQAEEEAAAA PAASTADKSL LTTPLNIVQP SEAPVEEDDF KPRPIIPMLY
     VVPRTKKVVF DKEHMSCQQA FEQFATQKSP GWREQTVSLE IPVKEEESAE AENTEIATET
     AAFSKMKMEI KKSRRHPLGK PPTRSPLSVV KQETSSDEET FPFSGEEDMS DPEALKSLLS
     LQWKNKAPNF PAERKFNAAA ALSEPYCAVC TLFYPYNQSL QMDKEAVPVS AGETTSFVHL
     SKCGQKTKPL IPEMCFTSSG ENIEPLPSNS YIGEDGTSSL ISCAKCCLQV HASCYGIRPD
     LVNESWSCSR CSANAWAAEC CLCNLRGGAL QMTTDGRWVH IICAIAVPEA RFLNVIERHP
     VDIAAIPEQR WKLKCVYCRK RMKKVSGACI QCSYEHCSTS FHVTCAHAAG VPMEPDDWPY
     VVSITCFKHK AANQNIQFRR EVTLGQTVIT KNRNGLYYRC KVIGMTTQTF YEVNFDDGSY
     SDNVYPESII SRDCIQLGPP PEGEMVQLQW TDGIIYKAKF IAAQINHIYQ VEFEDGSQLM
     VKRGDIYTLE EELPKRVKSR LSLSTGAPQE DVFSGDEMRA AKRPRLGNAR NPEEYGQNPD
     YLAFMESLLQ TQYQPGTQSN MF
//
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