ID G1N7Q3_MELGA Unreviewed; 1774 AA.
AC G1N7Q3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Laminin subunit beta 2 {ECO:0000313|Ensembl:ENSMGAP00000008260.3};
GN Name=LAMB2 {ECO:0000313|Ensembl:ENSMGAP00000008260.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000008260.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000008260.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000008260.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR Ensembl; ENSMGAT00000009050.3; ENSMGAP00000008260.3; ENSMGAG00000008010.3.
DR GeneTree; ENSGT00940000156060; -.
DR HOGENOM; CLU_001560_1_0_1; -.
DR TreeFam; TF312903; -.
DR Proteomes; UP000001645; Chromosome 14.
DR Bgee; ENSMGAG00000008010; Expressed in heart and 16 other cell types or tissues.
DR CDD; cd22299; cc_LAMB2_C; 1.
DR CDD; cd00055; EGF_Lam; 13.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR PANTHER; PTHR10574:SF448; WING BLISTER, ISOFORM B; 1.
DR Pfam; PF00053; Laminin_EGF; 13.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 12.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1774
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032774657"
FT DOMAIN 29..264
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 265..328
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 392..451
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 452..503
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 504..549
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 543..754
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 760..807
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 808..853
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 854..903
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 904..962
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 963..1014
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1015..1070
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1071..1118
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1119..1165
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT REGION 1317..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1238..1265
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1425..1491
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1700..1748
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1330..1344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 294..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 422..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 475..484
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 487..501
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 504..516
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 506..523
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 525..534
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 760..772
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 762..779
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 781..790
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 808..820
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 810..827
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 829..838
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 873..882
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 933..942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 987..996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1043..1052
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1071..1083
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1073..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1092..1101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1119..1131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1121..1138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1140..1149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1774 AA; 193187 MW; E899A2C518245B88 CRC64;
MDVLVLALLL AGVPAAGGWE EPDPSQGCAR GSCYPATGNL LVGRAQQLSA SSTCGLQGPQ
EYCIVSHLQD SEKCFTCDSR NPTLRESHRI ENVIYLHGPH SERSWWQSEN GVEHVSIQLD
LEGEFHFTHL IMKFKTFRPA AMLVERSADF GRSWKAYRYF AYNCSKLFPG IPTHPSGHIG
EVLCEQRYSE IEPSSHGEVI FKVLDPSIPV VDPYSPNIQE LLRVTNLRVN LTKLHTLGDN
LLDSRQEVLH KYYYAVDELV MRGSCFCHGH AAECAPAPGA PPSVPGMIHG RCVCKHHTQG
LNCERCEDFY HELPWRPAEG SSTNACRRCD CNEHSRRCHF DMAVFLATGN TSGAVCDGCQ
HNTMGRRCHL CKPFYYKDPS KDLRDPAVCR ACNCDPEGTV DGGLCDGADD PERGLIAGQC
RCKEHVQGPR CDRCKAGFFG LSAANPQGCQ RCRCDPRGTV ADGSQCDPIS GDCLCKRLVT
GRSCDQCLPE HWALSHDLPG CRPCECDVGG ARNNRCAAET GQCQCRRHIV GRQCEQVEPG
FYRINLDHYT YEAEDARLHK GSVVEREPHT DHPASWTGSG FARMQEGGWV EFHVSDVPFS
MEYDVIIRYE PQHSEPWKEV RVQVLRPSPV SASSPCGNTI PADDQLSTSL QSGARYVVLS
HPICLERGVP YTIRLELGCA TGQQDPTASV LIDSLVLLPR YSSMEMFIAG DPAAMGRRET
FERYRCAQHF HTVVPSPVAE PCSRLLHSLS AILHDGALPC LCDPQGSLSA ECQPQGGQCR
CKPNVVGRRC HRCSLGTFGF GPGGCRPCQC SGEGSLSAVC DTVTGQCPCR QGAHGSRCDR
CQPGHWGFPT CQPCQCNGHA EECDPQTGSC LRCRDHTDGE RCQRCAVGHF GNPALGSGQH
CRPCPCPDGP GGPRHFAASC YQDGRSRQVV CHCSPGYTGP RCDECAPGYY GDPLQPGGRC
LPCQCHNNID MTDPEACDRR TGQCLRCLYN TAGPHCAECQ PGYYGDALRH SCRRCSCNAL
GTDPSTCGPQ QCHCDQRSGQ CHCLPHVEGQ SCDRCSPNFW NLGSGQGCEP CACHPQHSLS
PACNQFTGQC SCRPGFGGRT CADCQEQHWG DPRLQCRACD CDPRGIASAQ CHRGSGHCDC
RPGVSGVRCD QCARGFSGTF PACQPCHPCF GDWDRVVQDL ASRTRALAQR VSLLHHTGAA
GAFEGTFRQL EENLATVRDA VAARNATATT ATFLTHATEG LRQQIGEATE KLTRLESELT
VAQDANFNAS HVLGMVDRGA RALNHSLQEL GQRLHALKTS NFLGAFDSIR QSHWESQDAE
RRADASTRVI PSPVSASSAT RHHTEQLLAS RRDAFNRQNA ASRRALTELA ARAQELSLHP
INKKVCGTAG DVPCAESPCG GAGCRDEDGA RRCGGLSCGG AVSKADSALD RARHAQEELR
RAAGEVAQLS HRVAEAKGKA DEAWLQAQAA LDKANQTRAR VEHSNKELRE LISHVKAFLS
QEGADPESIE VVASRVLELS LPASPAQIHR LAEEIKARVR SLASVDAILE QTAGDVRQAG
QLLQDAQRAK ARAEGVRGTA EAVQQALEEA RQAQGTAGQA LHSTAADIQH SERAIGTMQM
QTLGAEQQLA AAMERIGLLE GQTDALKVKR ANNSLAATRA HDAAGIARDR ASEAKQVLEG
PLRDRYRAAQ ELVQHRAQGA QQAGGRAQQL REEAAGLLQD AQGKLQKLRA LEEEYERNER
VLDAKVAQLD GLEARMREVL ATINQQVQIY NTCQ
//
