ID G1N8I9_MELGA Unreviewed; 2766 AA.
AC G1N8I9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Neurofibromin 1 {ECO:0008006|Google:ProtNLM};
GN Name=NF1 {ECO:0000313|Ensembl:ENSMGAP00000008632.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000008632.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000008632.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000008632.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019477514.1; XM_019621969.1.
DR Ensembl; ENSMGAT00000009432.3; ENSMGAP00000008632.3; ENSMGAG00000008314.3.
DR GeneID; 100546215; -.
DR KEGG; mgp:100546215; -.
DR CTD; 4763; -.
DR GeneTree; ENSGT00550000074797; -.
DR HOGENOM; CLU_000249_0_0_1; -.
DR TreeFam; TF300302; -.
DR Proteomes; UP000001645; Chromosome 21.
DR Bgee; ENSMGAG00000008314; Expressed in gizzard and 17 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 1163..1379
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1508..1666
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2711..2766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2729..2755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2766 AA; 311878 MW; 53656086AC10A92A CRC64;
MRIFGETAEK NLYLSQLIIL DTLEKCLAGQ PKDTMRLDET MLVKQLLPEI CHFIHTYREG
NQHAAELRNS ASGVLFSLSC NNFNAVFSRI STRLQELTVC SEDNADVHDI ELLQYISVDC
SKLKRLLQET VFKFKALKKV AQLAVINSLE KAFWNWVENY PDEFTKLYQT PQTDMADCAE
KLFDLVDGFA ESTKRKAAVW PLQIILLVLC PEIIQDIAKD VVEETKMNKK LFLDNLRKAL
AGHSGSRQLT ESAAIACVKL CKASTYINWE DNSVIFLLVQ SMVVDLKNLL FNPSKPFSRS
NQNADVDLMI DCLVSCFRIN PHNNQHFKIC LAQSSPSTFH YVLVNSLHRI ITNSALDWWP
RIDAVYCHSV ELRSMFSETL HKAIQGCGAH AAIRMTPSLT FKEKMTSLKF KEKPTDLETK
SYKFLLLSLV KLIHADPKLL LCNPRKQGPE TQGSTAELIT GLVQLVPQSS MPDIAQEAME
ALLVLHQLDS IDLWNPDAPI ETFWEISSQM LFYICKKLTS HQMLSSTEIL KWLREILICR
NKFLLKNKQS DRTSCHFLFL YDVSGGGTSQ MSLDHEEMMR CAPGATLRKG KGNSSMESTA
GCSGTPICRQ AQTKLEVALY MFLWSPDIEA VLVAMSCFRH LCEEADIRCG VDEVSVHNFL
PNYNTFMEFA SVSNMMSTGR AALQKRVMAL LRRIEHPTAG NTEAWEDTHA KWEQATKLIL
NYPKTKMEDG QVTESLHKTI VKRRMSHVSG GGSIDLSDTD SLQEWINMTG FLCALGGVCL
QHRSNAGLAT YSPPMGPVNE RKGSMISMVS TEGNAETPVS KFIDRLLTLM VCNHEKVGLQ
IRTNIKDLVG LELSPALYPM LFNKLKNTIS KFFDSQGQVL LTETNTQFVE QTIAIMKNLL
DNHTEGSSEH LGQASIETMM LNLVRYVRVL GNLVHAIQIK TKLCQLVEVM MERRDDLSFC
QEMKFRNKMV EYLTDWVMGT SNQATDEDVK CLTRDLDQAS MEAVVSLLAG LPLQPEEGDG
VDLMEAKSQL FLKYFTLFMN LLNDCSEVED ESAQTGGRKR GMSRRLASLR HCTVLAMSNL
LNANVDSGLM HSIGLGYHKD LQTRATFMEV LTKILQQGTE FDTLAETVLA DRFERLVELV
TMMGDQGELP IAMALANVVP CSQWDELARV LVTLFDSRHL LYQLLWNMFS KEVELADSMQ
TLFRGNSLAS KIMTFCFKVY GATYLQKLLE PLLRTVITSS EWQHVSFEVD PTRLEPTESL
EENQRSLLQM TEKFFHAIIN SSSEFPPQLR SVCHCLYQAT CHSLLNKATV KEKKENKKSV
VSQRFPQNSI GAVGSAMFLR FINPAIVSPY EAGILDKKPP PRIERGLKLM SKILQSIANH
VLFTKEEHMR PFNDFVKSNF DAARRFFLDI ASDCPASDTV NHSLSFISDG NVLALHRLLW
NNQEKIGQYL SSNRDHKAVG RRPFDKMATL LAYLGPPEHK PVADTHWSSL NLTSSKFEEF
MTRHQVHEKE EFKALKTLNI FYQAGTSKAG NPVFYYIARR FKTGQINGDL LIYHVLLTLK
PYYAKPYEIV VDLTHAGPSN RFKTDFLSKW FVVFPGFAYE NVSAVFIYNC NSWVREYTKY
HERLLTGLKG SKRLIFIDSP GKLAEHIEHD QQKLPAATLA LEEDLKVFHN ALKLAHKDTK
VSIKVGSTAV QVTSAERTRV LGQTVFLNDI YYASEIEEIC LVDENQFTLT IANQGTPLTF
MHQECEAIVR SIIHIRTRWE LSQPDSIPQH TKIRPKDVPG TLLNIALLNL GSSDPSLRSA
AYNLLCALTC TFNLKIEGQL LETSGLCIPA NNTLFIVSIS KTLAANEPHL TLEFLEECIS
GFSKSSIELK HLCLEYMTPW LSNLVRFCKH NDDAKRQRVT AILDKLITMT INEKQMYPSI
QAKIWGSLGQ ITDLLDVVLD SFIKTSATGG LGSIKAEVMA DTAVALASGN VKLVSSKVIG
RMCKIIDKTC LSPTPTLEQH LMWDDIAILA RYMLMLSFNN SLDVAAHLPY LFHVVTLLVA
TGPLSLRAST HGLVINIIHS LCTCSQLHFS EETKQVLRLS LTEFSLPKFY LLFGISKVKS
AAVIAFRSSY RDRSFSPGSY ERETFALTSL ETVTEALLEI MEACMRDIPT CKWLDQWTEL
AQKFAFQYNP SLQPRALVVF GCISKRVSHG QIKQIIRILS KGLESCLKGP DNYNSQVLIE
ATVIALTKLQ PLLNKDSPMH KALFWVAMAV LQLDEVNLYS AGTALLEQNL HTLDSLRVFN
DKSPEEVFME IRRPLEWHCK QMDHFVGLNF NSNFNFALVG HLLKGYRHPS PTTVARTVRI
LHTLLALVNK HRNCDKFEVN TQSVAYLAAL LTVSEEVRSR CSLKHRKSLL LTDVAMENVP
MDTYPIHHSD TSYRTLKENQ PWSSPKGSDR HLAASYPTVG QISPRTRKSM SLDMGQPSQA
NTKKLLGTRK SFDHLISDTK APKRQDMESG ITTPPKMRRV AENDYEMETQ RISPQQHPHL
RKVSVSESNV LLDEEVLTDP KIQALLLTVL ATLVKYTTDE FDQRILYEYL AEASVVFPKV
FPVVHNLLDS KINTLLSLCQ DPNLLNPIHG IVQSVVYHEE SPPQYQTSYL QSFGFNGLWR
FAGPFSKQTQ IPDYAELIVK FLDALIDTYL PGIDEETSEE SLLTPTSPYP PAVQSQLSIT
ANLNLSNSMT SLATSQHSPG IDKENVELSP TAGHTNSGRM RHGSASQVQK QRSAGSLKRH
SIKKIV
//
