GenomeNet

Database: UniProt
Entry: G1NCP2_MELGA
LinkDB: G1NCP2_MELGA
Original site: G1NCP2_MELGA 
ID   G1NCP2_MELGA            Unreviewed;       814 AA.
AC   G1NCP2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   22-NOV-2017, entry version 50.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSMGAP00000010535};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSMGAP00000010535};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000010535, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000010535, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000010535}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000010535}.
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DR   STRING; 9103.ENSMGAP00000010535; -.
DR   Ensembl; ENSMGAT00000011394; ENSMGAP00000010535; ENSMGAG00000010154.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; G1NCP2; -.
DR   OMA; WLGFHTF; -.
DR   OrthoDB; EOG091G038K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000001645; Chromosome 17.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF231; PTHR10037:SF231; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    107    129       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    135    155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    229    251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    442    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    504    522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    528    544       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    564    583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    663    688       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      138    327       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      438    687       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   814 AA;  94207 MW;  EA2F4BBD096A1283 CRC64;
     MAVSMDDDVP LILTLDDGGS GASAPRDSAD REELPGQNGG SYDIINDASS PAAGDCCAKQ
     SSAQHNWEMN YQEAAIYLQE GENNDKFFTH PKNAKALAAY LFAHNHLFYL MELSAALLLL
     LLSLCEAPAV PMLRLGIFVH ATLELFALMV VVFELSMKMR WLGFHTFIRH KRTMVKVSRL
     VLQQAGRQAA QGKESSVIEI EVFLLPCLHS DVFSIFRNLR QIFQSLPPFI DILLLLLFFM
     VIFAILGFYL FSPNHSDPYF NTLENSLVNL FVLLTTSNFP DVMMPSYARN PWSCVFFIVY
     LSIELYFIMN LLLAVVFDTF NDIEKRKFKS LLLHKRTAIQ HAYRLLITKQ GPPGISFRHF
     EGLLRFYKPR MCSRERYLTF KALNQGNTPL LSLKDFYNFY EVVGLKWKAK RNREHWFDDL
     PRTAFLIFKG INILVNSRLF QYTMYTVVAV NGIWILVETF MLQGGNFFSR NVPWSYIVFL
     TIYGVELLLK TTGLGPVEYL SSGWNLFDFS VTLFAFLGLM ALAFNMEPFY FIVVLRPLQL
     LRLFKLKKRY RNVLDTMFEL FPRMASLGLT LLIFYYCFAI VGMEFFAGAV YPNCCNTSTV
     ADSYRWVNHT VGNKTVIEEG YYYLNNFDNI LNSFVTLFEL TVVNDWYIIM EGVTSETTHW
     SRLYFMIFYI VTMVVMTIIV AFILEAFVFR MNYTRKNQDS EEDNGIVLEK EISKEEVIRI
     IELYKQSSPA TETSQLQKIV LQMDKHGQVS TLFLGRRSRT KSDLSMKMYE EEIQEWYEEH
     SRKEESQIPL QESASAFQSS LKPLSLRQRS QTVI
//
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