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Database: UniProt
Entry: G1NDU5_MELGA
LinkDB: G1NDU5_MELGA
Original site: G1NDU5_MELGA 
ID   G1NDU5_MELGA            Unreviewed;       859 AA.
AC   G1NDU5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   22-NOV-2017, entry version 41.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 3 {ECO:0000313|Ensembl:ENSMGAP00000011047};
GN   Name=TRPC3 {ECO:0000313|Ensembl:ENSMGAP00000011047};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011047, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000011047, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000011047}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000011047}.
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DR   STRING; 9103.ENSMGAP00000011047; -.
DR   Ensembl; ENSMGAT00000011916; ENSMGAP00000011047; ENSMGAG00000010636.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; G1NDU5; -.
DR   OMA; CMEKQRH; -.
DR   OrthoDB; EOG091G01FB; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000001645; Chromosome 4.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; IEA:Ensembl.
DR   GO; GO:1903244; P:positive regulation of cardiac muscle hypertrophy in response to stress; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005459; TRPC3_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF8; PTHR10117:SF8; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01644; TRPCHANNEL3.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    349    373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    436    453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    583    603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    623    639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    651    673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    709    727       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    100       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
SQ   SEQUENCE   859 AA;  98982 MW;  B1EE3D987C61BBA0 CRC64;
     ILQEGTESPS LRRMTMMREK GRRQAIRGPA FMFNNRGTSL TAEEERFLDA AEYGNIPVVR
     KMLEESKTLN VNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARIGDAL LLAISKGYIR
     IVEAILNHPG FSVNKRLTLS PCEQELQDDD FYSYDEDGTR FSPDITPIIL AAHCQKYEVV
     HMLLMKGARI ERPHDYFCKC NDCTEKQKHD SFSHSRSRIN AYKGLASPAY LSLSSEDPVL
     TALELSNELA KLANIEKEFK NDYRKLSMQC KDFVVGVLDL CRDSEEVEAI LNGDLNSEPV
     ETQRHRASLS RVKLAIKYEV KKFVAHPNCQ QQLLTIWYEN LSGLREQTIA IKCLVVLVVA
     LGLPFLAIGY WIAPCSRLGR ILRSPFMKFV AHAASFIIFL GLLVFNASDR FEGITTLPNV
     TVTDYPKQIF RVKTTQFTWT EMLIMVWVLG MMWSECKELW LEGPREYILQ LWNVLDFGML
     SIFIAAFTAR LLAFLQATKA QQYVDNYIEE SDLSEVTLPP EIEYFTYARD KWLPSDPQII
     SEGLYAIAVV LSFSRIAYIL PANESFGPLQ ISLGRTVKDI FKFMVLFIMV FLAFMIGMFI
     LYSYYLGAKL NPAFTTVEES FKTLFWSIFG LSEVTSVVLK YDHKFIENIG YVLYGIYNVT
     MVVVLLNMLI AMINSSYQEI EDDSDVEWKF ARSKLWLSYF DDGKTLPPPF SLVPSPKSFF
     YFIMRIINFS KCRRRRLQKD IEMGMGNSKS RLNLFTQSNS RVFESHSFNS ILNQPTRYQQ
     IMKRLIKRYV LKAQVDKEND EVNEGELKEI KQDISSLRYE LLEDKSQATE ELAILIHKLS
     EKLNPNMLKH LKVKNYQTF
//
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