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Database: UniProt
Entry: G1NE43_MELGA
LinkDB: G1NE43_MELGA
Original site: G1NE43_MELGA 
ID   G1NE43_MELGA            Unreviewed;      2005 AA.
AC   G1NE43;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   22-NOV-2017, entry version 50.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSMGAP00000011166};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011166, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000011166, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000011166}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000011166}.
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DR   STRING; 9103.ENSMGAP00000011166; -.
DR   Ensembl; ENSMGAT00000012035; ENSMGAP00000011166; ENSMGAG00000010669.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1NE43; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001645; Chromosome 7.
DR   GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0019227; P:neuronal action potential propagation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    400    427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    758    782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    794    815       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    877    905       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    964    990       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1215   1233       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1254   1273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1285   1308       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1329   1357       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1456   1479       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1538   1556       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1568   1586       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1598   1618       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1655   1683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1759   1782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    434       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      513    716       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      767    994       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1004   1209       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1213   1487       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1537   1792       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      424    462       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2005 AA;  227300 MW;  872253B4981EADBB CRC64;
     MEQSVLVPPG PDSFQYFTRE SLAAIEQRIA AEKAKNSKQD RKDDDENGPK PNSDLEAGKT
     LPFIYGDIPP GMVSEPLEDM DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPFNPLRKI
     AIKILIFGLF SMLIMCTILT NCVFMTMSNP PDWTKNVEYT FTGIYTFESL IKIIARGFCL
     EDFTFLRDPW NWLDFTVITF AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPENFTLETN ITSQLNSTIG
     ENGTLVNSTV TPFDWKGYIE DESHFYFLEG QNDALLCGNS SDAGQCPEGY TCVKAGRNPN
     YGYTSFDTFS WAFLSLFRLM TQDFWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLINLIL
     AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEAAQ AAAVAAAAVT ASAESREPSA
     AGEAGGLSES SSEASKLSSK SAKERRNRRK KRKQKEQSGG EEKDEDEFHK SESEDSIRRK
     GFRLSIEGNR LTYEKKYSSP HQSLLSIRGS LFSPRRNSRT SLFSFRGRAK DIGSENDFAD
     DEHSTFEDND SRRDSLFVPI SQASRSSRML AVFPVNGKMH STVDCNGVVS LVGGPSVPTS
     PVGQLLPEVI IDKPATDDNG TTTETEMRKR ISGSFHVSMD YLEDPALRER AMSIASILTN
     TVEELEESRQ KCPPCWYKFA NIFLIWDCSP HWLKVKHIVN LVVMDPFVDL AITICIVLNT
     LFMAMEHYPM TDEFNNVLSV GNLVFTGIFT AEMFLKIIAM DPYYYFQEGW NIFDGFIVTL
     SLVELGLADV EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF
     IFAVVGMQLF GKNYKECVCK IASDCVLPRW HMQDFFHSFL IVFRVLCGEW IETMWDCMEV
     AGQAMCLTVF MMVMVIGNLV VLNLFLALLL SSFSADNLAV TDDDNEMNNL QIAVARMQKG
     IDYVKRKARE FIQKAFVKKQ KALDEIKPLE DLNNKNSCIS NHTAELSKDH DYIKDVNGTT
     SGIGTGSSVE KYIIDESDYM SFINNPSLTV TVPIAVGESD FENLNTEEFS SESDLEESKE
     KLNMSSSSEG STVDIGLPAE EQPEAEPEES MEPEACFTEG CVRRFKCCQV SVEEGRGKQW
     WNLRKTCFRI VEHNWFETFI VFMILLSSGA LAFEDIYIEQ RKTIKTMLEY ADKVFTYIFI
     LEMLLKWVAY GYQTYFTNAW CWLDFLIVDV SLVSLTANAL GYSELGAIKS LRTLRALRPL
     RALSRFEGMR VVVNALLGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY YCVNTTTDER
     FEVDQINNFS QCEELIKNNQ SARWKNVKVN FDNVGFGYLS LLQVATFKGW MDIMYAAIDS
     REVLQQPKYE DNLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ
     KKYYNAMKKL GSKKPQKPIP RPGNKFQGMV FDFVTQQVFD ISIMILICLN MVTMMVETDD
     QSKEMENILY WINLVFIVLF TGECVLKLIS LRHYYFTIGW NIFDFVVVIL SIVGMFLAEM
     IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY
     AIFGMSNFAY VKREAGIDDM FNFETFGNSM ICLFQITTSA GWDGLLAPIL NSGEPDCDPN
     KAHPGSSVKG DCGNPSVGIF FFVSYIIISF LVVVNMYIAV ILENFGVATE ESAEPLSEDD
     FEMFYEVWEK FDPDATQFME FEKLSDFAAA LEPPLHLPKP NKVQLIAMDL PMVSGDRIHC
     LDILFAFTKR VLGESGEMDA LRIQMEDRFM ASNPSKASYE PITTTLKRKQ EEVSAVIIQR
     AFRRHLLKRT VKQASFIYNK NKTEGGAGLG IKDEILMDKL NENSFTEKTD ITASTAVCPP
     SYDRVTRAVK EKHEKEDKDV QKKGG
//
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