ID G1NE90_MELGA Unreviewed; 665 AA.
AC G1NE90;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
GN Name=TUBGCP4 {ECO:0000313|Ensembl:ENSMGAP00000011221.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011221.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000011221.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000011221.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC at the centrosome. {ECO:0000256|RuleBase:RU363050}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
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DR RefSeq; XP_003209663.2; XM_003209615.3.
DR AlphaFoldDB; G1NE90; -.
DR Ensembl; ENSMGAT00000012091.3; ENSMGAP00000011221.3; ENSMGAG00000010769.3.
DR GeneID; 100550451; -.
DR KEGG; mgp:100550451; -.
DR CTD; 27229; -.
DR GeneTree; ENSGT00940000156677; -.
DR HOGENOM; CLU_012029_0_0_1; -.
DR InParanoid; G1NE90; -.
DR TreeFam; TF324188; -.
DR Proteomes; UP000001645; Chromosome 12.
DR Bgee; ENSMGAG00000010769; Expressed in breast and 17 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF27; GAMMA-TUBULIN COMPLEX COMPONENT 4; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 2..346
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 349..653
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 423..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 75782 MW; 9F6F7F0E9F94A12C CRC64;
MIHELLLALS GYPGAAFTWS KRGGLQVSQE LPFLHPSETS VLNRLCRLGT DYIRFAEFVE
QHTGHVQQQD HHLSQQNQSG LHGIYLRAFC TGLDSVLQPY RQALLDLEQE FLADPHLSIS
HVNYSLDQFQ LLFPSVMVVV EQIKTQKIHG CQILETVHKH SCGGLPPVRS ALEKILAVCH
GVMYKQLSAW MLHGLLLDQH EEFFIKQGPS GNISGQPEDD DDDLGIGGLT GKQLRELQDL
RLIEEENMLA PSLKQFSLRV EMLPSYIPVR VAEKILFVGE SVQMFENQNV NLTRKGSILK
NQEDTFAAEL HRLKQQPLFS LVDFESVVDW IRSTVAEHLW KLMVEESDLL GQLKIIKDFY
LLGRGELFQA FIDTAQHMLK TPPTAVTEHD VNVAFQQSAH KVLLDDDNLL PLLHLTIEYH
GKEHKDSSQT REGPSRELSP REAPTSGWAA LGLSYKVQWP LHILFTPAVL EKYNVVFKYL
LSVRRVQAEL QHCWALQMQR KHLKSNRTDA IKWRLRDHMA FLVDNLQYYL QVDVLESQFS
QLLQQINATR DFESIRLAHD HFLSNLLAQS FILLKPVFHC LNEILDLCHS FCSLVSQNLG
PLDERGAAQL SILVKGFSRQ SSLLFKILSS VRNHQINSDL AQLLLRLDYN KYYTQAGGTL
GSFGV
//
