ID G1NEG5_MELGA Unreviewed; 1757 AA.
AC G1NEG5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011323.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000011323.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000011323.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR Ensembl; ENSMGAT00000012196.3; ENSMGAP00000011323.3; ENSMGAG00000010850.3.
DR GeneTree; ENSGT00940000158287; -.
DR HOGENOM; CLU_000085_4_1_1; -.
DR InParanoid; G1NEG5; -.
DR TreeFam; TF315253; -.
DR Proteomes; UP000001645; Chromosome 5.
DR Bgee; ENSMGAG00000010850; Expressed in proventriculus and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF12; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 ISOFORM X1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF00058; Ldl_recept_b; 15.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS51120; LDLRB; 16.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1577..1598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 274..289
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 336..378
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 379..421
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 422..465
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 466..508
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 642..684
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 685..727
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 728..771
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 772..814
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 950..992
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 993..1035
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1036..1079
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1080..1121
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1254..1296
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1297..1339
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1340..1383
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1384..1425
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1516..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..1757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4..16
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 11..29
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 23..38
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 47..59
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 54..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 66..81
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 87..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 94..112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 106..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 126..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 133..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 145..160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 168..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 175..193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1757 AA; 196099 MW; 321C707BBC4E2523 CRC64;
MRKCSEKEFR CSDGSCIAEH WFCDGDTDCK DGSDEENCPS DVPAATCSLE EFQCAYGRCI
LDIYHCDGDD DCGDWSDESD CSSHQPCRSG EFMCNSGLCI NAGWRCDGDS DCDDQSDERN
CTTSMCTADQ FRCKSGRCVR LSWRCDGEDD CSDNSDEENC ENTGTPQCAP DQFLCGNGRC
IGQRKLCNGA NDCGDGSDES PHQNCRPRTG EENCNINNGG CAQKCQMVRG MVQCTCHTGY
RLLEDGRSCQ DVNECAEEGY CSQGCTNSEG GFQCWCEQGY ELRPDKRSCK ALGPEPVLLF
ANRIDIRQVL PHRSEYTLLL NNLENAIALD FHHSKELVFW SDVTLDRIMR ANLNGSNVEE
VVSTGLESPG GLAIDWIHDK LYWTDSGTSR IEVANLDGTH RKVLLWQNLE KPRAIALHPM
EGTIYWTDWG NTPRIEYSNM DGSNRRIIAD THLFWPNGLT IDYAGHRMYW VDAKHHVIER
ADLDGRNRKA VISQGLPHPF AITVFEDSLY WTDWHTKSIN SANKFTGKNQ EIIRNKLHFP
MDIHTLHPQR QPAAGRNRCG ANNGGCTHLC LPSSKDYTCA CPTGFRKTSS HACAQSLDKF
LLFARRMDIR RISFDTDDLS DDVIPLADVR SAVALDWDSK DDYVYWTDVS TDSISRAKWD
GSGQEVVVDT SLESPAGLAI DWVTNKLYWT DAGTDRIEVS NTDGTMRTVL IWENLDRPRD
IVVDPVGGFM YWTDWGANPK IERAGMDASN RLVIISSNLT WPNGLAIDYE SQRLYWADAG
MKTIEYASLD GSNRKVLIGS NLPHPFGLTL YGERIYWTDW QAKSIQSADR RTGQARETLQ
DNLENLMDIH VFHRHRPPVH TPCEVNNGGC SHLCLLAPLP KGYSCTCPTG INLQSDGKTC
STGMTSFLIF ARRTDIRMVS LDIPYFADVV VSVNVTMKNT IAIGVDPHEG KVYWSDSTLR
KISRAALDGS KFEDIITTGL LTTDGLAVDA IGRKIYWTDT GTNRIEVGNL DGSMRKVLVW
QNLDSPRAIA LYHEMGYMYW TDWGENAKLE RSGMDGSGRV VLISNNLGWP NGLAVDKAGS
QLLWADAHTE RIEAADLNGA NRRTLLSPVQ HPYGLTLLDS YIYWTDWQTR SIHRADKDSG
ANVILVRANL PGLMDIQAVD RARPLGFNKC GVRNGGCSHL CLPHPTGFSC ACPTGIQLKR
DEQTCDSSPE TYLLFSSRAS IRRISLDTSD HTDVHIPVPE LNNVISLDYD SVDGKIYYTD
VFLDVIRRSD LNGSNMETVI GQGLKTTDGL AVDWVARNLY WTDTGRNTVE VARLDGSSRK
VLINNSLDEP RAIAVFPKKG YLFWTDWGHV AKIERANLDG SERKILINTD LGWPNGLTLD
YDTRRIYWVD AHLDRIESCD LNGKLRQVLV SQVSHPFALT QQDRWIYWTD WQTKSIQRVD
KYSGRNKETV LANVEGLMDI IVVSPQRQTG TNACGVNNGG CTHLCFARAS DFVCACPDEP
DGRPCSTVPG VVPFGPEITS ERSQTPPGRI GTSTTKPLTS LEEEEGNCSD KDARRGLCTH
ANEAVLATMG EGLHVSYIIG GLLSILFILL LIASLIIYRH NKSKFTDPGL GNLTYSNPSY
RTSTQEVKIE TIPKPTMYNQ LCYKKETGPD HSYTKEKIKI VEGICLLSSD DSEWDDLKQI
RSSRGGILRD HVCMKTDTVS IQASSGSLDD TETEQLLQEE QSECSSVNTA AATPERRGSL
PDTGWKHQRK PSTESEV
//
